A 36-year-old man came to meet a gastroenterologist with a terrible abdominal pain which lasted for several days. During the endoscopic examination, the doctor noticed two ulcers and prominent gastric folds in the stomach. Relevant laboratory test results are as follows: Gastric pH: < 2.0 Fasting gastrin: 1500 pg/mL (normal: < 90 pg/MI) Basal gastric acid output: > 15 mEq/h (normal: < 15 Eq/h) The doctor suspects that the increased stomach acid is a condition of Zollinger-Ellison syndrome (ZES) which is a rare disorder caused by gastrin-producing tumours in the pancreas called gastrinomas. The excess gastrin causes hyperacidity, mucosal disruption/ulcers and proliferation of acid-producing cells or more gastric folds of the stomach (i) How is acid generated in the stomach? Which cells secrete acid? (ii) How is secretion of gastric acid normally regulated? In your answer, indicate why fasting gastrin is used for diagnosing gastrinoma.

A 36-year-old man came to meet a gastroenterologist with a terrible abdominal pain which lasted for several days. During the endoscopic examination, the doctor noticed two ulcers and prominent gastric folds in the stomach. Relevant laboratory test results are as follows: Gastric pH: < 2.0 Fasting gastrin: 1500 pg/mL (normal: < 90 pg/MI) Basal gastric acid output: > 15 mEq/h (normal: < 15 Eq/h) The doctor suspects that the increased stomach acid is a condition of Zollinger-Ellison syndrome (ZES) which is a rare disorder caused by gastrin-producing tumours in the pancreas called gastrinomas. The excess gastrin causes hyperacidity, mucosal disruption/ulcers and proliferation of acid-producing cells or more gastric folds of the stomach (i) How is acid generated in the stomach? Which cells secrete acid? (ii) How is secretion of gastric acid normally regulated? In your answer, indicate why fasting gastrin is used for diagnosing gastrinoma.

Surgical Tech For Surgical Tech Pos Care

5th Edition

ISBN:9781337648868

Author:Association

Publisher:Association

Chapter4: Special Populations

Section: Chapter Questions

Problem 4QFS

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