### Problem 8: Analysis of Lipitor StructuresTwo structures of Lipitor, a medication used to lower cholesterol, are depicted. The task consists of two parts:**(a) Determining Absolute Configuration:**For each indicated stereocenter, determine the absolute configuration by selecting either R or S for the following:- **Carbon a:** - Options: ⚪ R ⚪ S- **Carbon b:** - Options: ⚪ R ⚪ S- **Carbon c:** - Options: ⚪ R ⚪ S- **Carbon d:** - Options: ⚪ R ⚪ S**(b) Structural Comparison:**Determine if the two structures represent:- ⚪ The same compound- ⚪ Stereoisomers### Explanation:The diagram shows two complex organic molecules with several aromatic rings and other functional groups. Key carbons (a, b, c, and d) are identified for configuration assessment. Participants must analyze the stereochemical properties based on molecular geometry around these carbons and fill in the correct configurations and structural relationship.

Given is organic compound. Stereoisomers are isomers that differ in spatial arrangement of atoms or…

8. Two structures of Lipitor (a drug used to lower cholesterol) are shown below. (a) Determine the absolute configuration of each indicated stereocenter. Fill in the correct circle. (b) Determine if the two structures are the same compound or stereoisomers. Fill in the correct circle. (a) OH OH O Carbon a jag att HO,,, Carbon c HO O OH Carbon a: OR OS Carbon b Carbon b: OR OS Carbon c: OR S Carbon d: OR S OH Carbon d (b) The two structures are: O the same compound O stereoisomers

8. Two structures of Lipitor (a drug used to lower cholesterol) are shown below. (a) Determine the absolute configuration of each indicated stereocenter. Fill in the correct circle. (b) Determine if the two structures are the same compound or stereoisomers. Fill in the correct circle. (a) OH OH O Carbon a jag att HO,,, Carbon c HO O OH Carbon a: OR OS Carbon b Carbon b: OR OS Carbon c: OR S Carbon d: OR S OH Carbon d (b) The two structures are: O the same compound O stereoisomers

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter3: Stereoisomerism And Chirality

Section3.7: Optical Activity—how Chirality Is Detected In The Laboratory

Problem 3.10P

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Concept explainers

Alkanes and Cycloalkanes

Alkanes are saturated organic compounds which are made up of C and H atoms. Alkanes have the general formula of CnH2n+2. Alkane contains sp3 hybridized carbon atoms with four sigmas (σ) bonds & every hydrogen atom is connected with one of the carbon atoms. The size of the alkane could be determined by the number of carbon atoms located in it.

Question

### Problem 8: Analysis of Lipitor Structures

Two structures of Lipitor, a medication used to lower cholesterol, are depicted. The task consists of two parts:

**(a) Determining Absolute Configuration:**

For each indicated stereocenter, determine the absolute configuration by selecting either R or S for the following:

- **Carbon a:**
- Options: ⚪ R ⚪ S

- **Carbon b:**
- Options: ⚪ R ⚪ S

- **Carbon c:**
- Options: ⚪ R ⚪ S

- **Carbon d:**
- Options: ⚪ R ⚪ S

**(b) Structural Comparison:**

Determine if the two structures represent:

- ⚪ The same compound
- ⚪ Stereoisomers

### Explanation:

The diagram shows two complex organic molecules with several aromatic rings and other functional groups. Key carbons (a, b, c, and d) are identified for configuration assessment. Participants must analyze the stereochemical properties based on molecular geometry around these carbons and fill in the correct configurations and structural relationship.

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