Organic Chemistry: A Guided Inquiry
Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN: 9780618974122
Author: Andrei Straumanis
Publisher: Cengage Learning
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### Problem 8: Analysis of Lipitor Structures

Two structures of Lipitor, a medication used to lower cholesterol, are depicted. The task consists of two parts:

**(a) Determining Absolute Configuration:**

For each indicated stereocenter, determine the absolute configuration by selecting either R or S for the following:

- **Carbon a:**
  - Options: ⚪ R   ⚪ S

- **Carbon b:**
  - Options: ⚪ R   ⚪ S

- **Carbon c:**
  - Options: ⚪ R   ⚪ S

- **Carbon d:**
  - Options: ⚪ R   ⚪ S

**(b) Structural Comparison:**

Determine if the two structures represent:

- ⚪ The same compound
- ⚪ Stereoisomers

### Explanation:

The diagram shows two complex organic molecules with several aromatic rings and other functional groups. Key carbons (a, b, c, and d) are identified for configuration assessment. Participants must analyze the stereochemical properties based on molecular geometry around these carbons and fill in the correct configurations and structural relationship.
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Transcribed Image Text:### Problem 8: Analysis of Lipitor Structures Two structures of Lipitor, a medication used to lower cholesterol, are depicted. The task consists of two parts: **(a) Determining Absolute Configuration:** For each indicated stereocenter, determine the absolute configuration by selecting either R or S for the following: - **Carbon a:** - Options: ⚪ R ⚪ S - **Carbon b:** - Options: ⚪ R ⚪ S - **Carbon c:** - Options: ⚪ R ⚪ S - **Carbon d:** - Options: ⚪ R ⚪ S **(b) Structural Comparison:** Determine if the two structures represent: - ⚪ The same compound - ⚪ Stereoisomers ### Explanation: The diagram shows two complex organic molecules with several aromatic rings and other functional groups. Key carbons (a, b, c, and d) are identified for configuration assessment. Participants must analyze the stereochemical properties based on molecular geometry around these carbons and fill in the correct configurations and structural relationship.
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