64. Cisplatin [cisdiamminedichloroplatinum (II)] is a potent treatment for certain types of cancers, but the trans isomer is not effective. What is the equilib- rium constant at 298 K for the transformation of the cis to the trans isomer? Which is the favored isomer at 298 K, the cis or the trans isomer? Compound AH° (kJ/mol, 298 K) A,G° (k]/mol, 298 K) Cis-Pt(NH,),CI, Trans-Pt(NH,),Cl, -467.4 -228.7 -480.3 -222.8 H,N Pt. NH3 CL CL H,N. Pt. CL H,N dis isomer CL trans isomer

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64. Cisplatin [cisdiamminedichloroplatinum (II)] is a
potent treatment for certain types of cancers, but
the trans isomer is not effective. What is the equilib-
rium constant at 298 K for the transformation of the
cis to the trans isomer? Which is the favored isomer at
298 K, the cis or the trans isomer?
Compound
A,H° (kJ/mol, 298 K)
AG° (kJ/mol, 298 K)
Cis-Pt(NH;),CI,
Trans-Pt(NH,),Cl,
-467.4
-228.7
-480.3
-222.8
H,N.
Pt
CL
H,N
Pt.
CL
H,N
cis isomer
H,N
NH,
trans isomer
Transcribed Image Text:64. Cisplatin [cisdiamminedichloroplatinum (II)] is a potent treatment for certain types of cancers, but the trans isomer is not effective. What is the equilib- rium constant at 298 K for the transformation of the cis to the trans isomer? Which is the favored isomer at 298 K, the cis or the trans isomer? Compound A,H° (kJ/mol, 298 K) AG° (kJ/mol, 298 K) Cis-Pt(NH;),CI, Trans-Pt(NH,),Cl, -467.4 -228.7 -480.3 -222.8 H,N. Pt CL H,N Pt. CL H,N cis isomer H,N NH, trans isomer
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