Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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please answer the blanks for part a and b

**THEME 2: About association mapping:**

Imagine you are studying the genetic basis of gout using GWAS and have available molecular markers (single nucleotide polymorphism tags or SNP tags) located all over the genome. Your results are displayed below.

*[Image displays a Manhattan plot illustrating the p-values of genetic variants across chromosomes. Each dot represents a SNP, and the y-axis shows the negative logarithm of the p-values (-log10 P-value). Chromosomes are represented on the x-axis, with chromosome 4 having the most significant peaks labeled ABCG2 and SLC2A9, and chromosome 11 having a peak labeled MYL2-CUX2.]*

a) From the plot above, which chromosome/s would be the focus of your future studies in search of the genes that might be responsible for gout? Chromosome/s ______ .

b) Briefly justify your choice/s for item a: I choose those chromosomes because ____________ .
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Transcribed Image Text:**THEME 2: About association mapping:** Imagine you are studying the genetic basis of gout using GWAS and have available molecular markers (single nucleotide polymorphism tags or SNP tags) located all over the genome. Your results are displayed below. *[Image displays a Manhattan plot illustrating the p-values of genetic variants across chromosomes. Each dot represents a SNP, and the y-axis shows the negative logarithm of the p-values (-log10 P-value). Chromosomes are represented on the x-axis, with chromosome 4 having the most significant peaks labeled ABCG2 and SLC2A9, and chromosome 11 having a peak labeled MYL2-CUX2.]* a) From the plot above, which chromosome/s would be the focus of your future studies in search of the genes that might be responsible for gout? Chromosome/s ______ . b) Briefly justify your choice/s for item a: I choose those chromosomes because ____________ .
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Step 1: Genome-Wide Association Study (GWAS)

Genome refers to the complete set of genes or the complete genetic makeup of an individual organism. Genes are responsible for controlling social characteristics (traits) in an organism.

Genome-wide association studies are research studies that involve the study of the effects of genes and how these genes are linked to their specific traits.

In the GWAS, the small genomic variants called the SNPs (Small Nucleotide Polymorphisms) are studied which are statistically correlated to their traits/ disease.


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