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- 3. In the family pedigree shown in the following chart, an abnormal trait is inherited as a simple recessive. Unless there is evidence to the contrary, assume that the individuals who have married into this family do not carry the recessive gene for the trait. Colored squares and circles represent expressions of the trait (see figure). Calculate the probability of the trait appearing in a given offspring if the following cousins and second cousins in generations III and IV should marry:_ (a) III-1 x III-12; (b) III-4 x III-14; (c) III-6 x II-13: (d) IV-1 x IV-2 2 3 10 11 12 13 14 15 16 IV 24. (1) How many females and males are affected in this pedigree? (2) Who is the proband? II (3) How many generations are included? 1 2 3 4 5 6 7 (4) What kind of inheritance pattern is the disease- causing allele in this pedigree? Why? 1 2 3 4 5 7 8 9. (5) Who have the same genotype as the proband? Why? 5. The figure below shows a pedigree of a genetic disorder caused by the X-linked recessive allele X'. Determine the genotype or possible genotypes of everyone in generations I, II and III. II 3 5 8. IV 1 2 3 4 56 7 8 9 10 1 12 13 14 15 16 17 18 19 2015. Albinism in corn plants is caused by a recessive lethal gene that results in death before maturity. What will the adult phenotypic ratio be for the F1 generation of heterozygous parents? 16. Huntington's chorea is a dominant lethal in humans. The disease does not appear until later in life, so that afflicted individuals may already have produced children. What are the F1 genotypic and phenotypic ratios of parents who are homozygous dominant and heterozygous?
- 9. In the F2 Generation, both the male and female pea plants are heterozygous for round/wrinkles seeds. 1)Draw a Punnett square that shows this cross. 2)What are the possible genotypes? 3)What are the possible phenotypes? 10. In pea plants, the allele for smooth pods (P) is dominant over the allele for pinched pods (p). Construct a Punnett Square that shows a cross between an PP plant and an Pp plant. Predict what percent of the offspring are likely to have smooth pods. Essay: Is it possible for a son to inherit an allele on an X chromosome from his father? Explain why or why not.5. The pedigree below traces the inheritance of Albinism, a genetic disorder. Affected individuals, indicated here by the coloured circles and squares, are unable to make a normal amount of melanin, the chemical that is responsible for eye, skin, and hair colour. Does Albinism appear to be caused by a dominant allele or by a recessive allele? Fill in the genotypes of the individuals whose genotypes can be deduced. What genotypes are possible for each of the other individuals? Explain! Naruto Hinata Reiner Asta Hange Mikasa Eren Historia Luffy Nezuko Zenitsu Tanjiro Son Goku20. 20.Which among the following statements is INCORRECT? A. Codominance is evident when a cross between organisms with two different phenotypes produces offspring that exhibits both parental traits because the alleles for each trait are neither completely dominant nor recessive B. Incomplete dominance is evident when a cross between a white carnation and a red carnation results in a pink carnation flower. C. Law of dominance state that if the alleles of a specific gene differ from each other, only one phenotype will be expressed while the other is masked D. The inheritance of one trait does not affect the inheritance of the other trait especially if the allele of the other trait is located in a different chromosome
- 7. A couple with widow's peaks, an autosomal dominant trait, have two grown daugh- ters and one grown son. The daughters do not have a widow's peak (straight hair line). Their son does have a widow's peak. He married a straight hair lined woman, and they have two daughters. Draw a pedigree that represents this scenario tracking the straight hair lined trait. Make sure to label all generations and provide potential genotypes for each individual on the pedigree. 8. Observe the sex-linked pedigree provided here that is tracking the red-green color- blindness trait. Please determine the genotypes for all unknown individuals: Human Genomte P Genotype: b. Genotype: a. C. Genotype: d. Genotype: Genotype: f. Genotype: g. Genotype: h. Genotype: e. II III apter B Loo 04 C □O A D SG H6. Below is a pedigree of a rare human genetic disease. The filled in symbols indicate affected individuals. Assume that the disease is caused by a mutant allele of gene A. a. Based on this pedigree, what is the most likely mode of inheritance? b. What is/are the possible genotype(s) of person 1, 2, 3 and 4? c. If individuals 1 and 4 have a child together, what is the probability that the child will exhibit the disease? 50% d. If individuals 2 and 3 have a child together, what is the probability that the child will exhibit the disease? 2 3 42. Brown eyes are dominant over blue eyes in humans. Having a peaked hairline is dominant over having a smooth hairline in humans. Two such humans decide to have offspring – who will also be human, because you know – genes. One of the parents has blue eyes and is heterozygous for a peaked hairline. The other parent is brown-eyed with a peaked hairline but is heterozygous for both traits. a) Complete a Punnett square showing all possible genotypes of their offspring. b) What is the probability of this couple producing a child with blue eyes? c) What is the probability of producing a child who has both brown eyes and a smooth hairline?
- 2. Uniparental disomy is a rare phenomenon in whichonly one of the parents of a child with a recessivedisorder is a carrier for that trait; the other parent ishomozygous normal. By analyzing DNA polymorphisms, it is clear that the child received both mutantalleles from the carrier parent but did not receive anycopy of the gene from the other parent.a. Diagram at least two ways in which uniparentaldisomy could arise. (Hint: These mechanismsall require more than one error in cell division,explaining why uniparental disomy is so rare.)Is there any way to distinguish between thesemechanisms to explain any particular case ofuniparental disomy?2. Uniparental disomy is a rare phenomenon in whichonly one of the parents of a child with a recessivedisorder is a carrier for that trait; the other parent ishomozygous normal. By analyzing DNA polymorphisms, it is clear that the child received both mutantalleles from the carrier parent but did not receive anycopy of the gene from the other parent.a. Diagram at least two ways in which uniparentaldisomy could arise. (Hint: These mechanismsall require more than one error in cell division,explaining why uniparental disomy is so rare.)Is there any way to distinguish between thesemechanisms to explain any particular case ofuniparental disomy?b. How might the phenomenon of uniparental disomyexplain rare cases in which girls are affected withrare X-linked recessive disorders but have unaffectedfathers, or other cases in which an X-linked recessive disorder is transmitted from father to son?c. If you were a human geneticist and believed oneof your patients had a disease syndrome caused…12. A summer student accidentally brought in a new heterozygous strawberry plant (with small red berries) that had different parents. The parents of the new plant had small, black berries and large, red berries. Fortunately the technician knew that both parents of the new strawberry plant were pure breeding (i.e., homozygous for both traits). Draw a Punnett square to illustrate the cross between the new heterozygous strawberry and a strawberry plant with large, black fruit. Using the map units and percentage recombination you calculated in question #11, calculate the expected genotypic ratio and phenotypic frequencies amongst the offspring of this cross. Show all of your work.