5' сТА АG-OC T G ATT сGA 3' 1 3' DNA contains oxidized guanine (G-O) as a result of oxidation damage. 5' 5' ČÍÁ Á G ATT сGA 3' 3 Glycosylase removes the oxidized nucleobase from the 5' sugar-phosphate backbone. 2 ст Cut 5' сТА А ст G ATT сGA 3' 3' At the site of the missing nucleobase, an enzyme cuts the 5' sugar-phosphate backbone. 5' 3' DNA polymerase degrades a short stretch of the strand. 5' ст G ATT сGA 3' 5' 3' The combined actions of DNA сТА А Gст G ATT сGA 3' polymerase and DNA ligase 1 5' fill in and seal the gap. FIGURE 8.11 Repair of Oxidized Guanine in

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Picture a campfire. It keeps the body warm on a cold night and provides light. To ensure that the fire keeps burning, fuel needs to be added(pieces of wood in this case). When a small piece is added, the fire burns bright for a bit and then dies down unl…

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