4. An enzyme (acetoacetate decarboxylase) catalyzes the decarboxylation of acetoacetate. The mechanism has been studied extensively; concluding that the key bond-breaking step involves an enamine as a leaving group. Draw a curved arrow mechanism in the boxes below. Label the “iminium” and then “enamine" and then “iminium” as three consecutive intermediates in the mechanism. Note that the acid is stoichiometric PLUS catalytic. (Hint: acid-base involving oxygen should be drawn concerted with other steps) Enz 요요 (cat.) NH2 EnzAH EnzAH (cat.) O=C=0 EnzA

Provide a detailed mechanism for the following reaction

Give detailed Solution with explanation needed

single reaction sequence: a certain ketone undergoes alkylation to give new ketone, when reacted with a base and then an alkylating agent, 1-bromopropane. What is the structure of the final ketone product?

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Refer to the reaction energy diagram to answer parts (a) through (e). (a) What is the rate-limiting STEP? (Select from 1, 2, 3, or 4) (b) The TRANSITION STATE for the fastest step is: (c) In the 3rd step which INTERMEDIATE structurally resembles the transition state according to the Hammon postulate? (d) Which STEP NUMBER is endergonic? (e) The number of intermediates in the overall reaction is:

Provide an arrow pushing mechanism for the following reaction. Include protons and each step clearly indicated. OEt NaOEt, EtOH EtO OEt OEt OEt NaOEt, EtOH then H* work up

On a scrap piece of paper, draw a curved arrow mechanism for the following reaction. Once you have determined the major organic product, draw it in the space provided below. -Br 1) Ph P 2) n-BuLi 3) H

1. Take a close look at the following reactions. (a) Draw the product in the box below. (b) Provide the mechanism in the space below the reaction scheme. H₂O, H₂SO4

Use a scrap piece of paper to draw the curved arrow mechanism for the reaction below. Use your mechanism to help you determine the major organic product formed, then draw it in the space provided.