31; logP = 4.56) on some- eldrin has a half-life of ab ermeability of about 3 x 1 ate during the exposure pe n concentration (i.e., tak

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Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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2. An 84 kg University of Toledo groundskeeper who is spraying a 100 mg/L solution of the
insecticide dieldrin (MW = 381; logP = 4.56) on some trees exposes 100 cm“ of his skin to the
solution over a 4 hr period. Dieldrin has a half-life of about 6 months, a volume of distribution of
about 40 L/kg, and a dermal permeability of about 3 x 10° cm/sec.
(a) Estimate the absorption rate during the exposure period assuming the blood concentration is
much lower than the skin concentration (i.e., take the blood level to be zero in the skin
absorption equation).
(b) Estimate how it takes after exposure begins for the groundskeeper's plasma dieldrin levels to
reach 1 ng/L.
(c) Estimate the maximum plasma dieldrin concentration in ng/L that will occur in this
groundskeeper due to this exposure.
(d) Estimate how long it will take after exposure ends for the groundskeeper's plasma dieldrin
levels to drop back down to 1 ng/L.
%3D
Transcribed Image Text:2. An 84 kg University of Toledo groundskeeper who is spraying a 100 mg/L solution of the insecticide dieldrin (MW = 381; logP = 4.56) on some trees exposes 100 cm“ of his skin to the solution over a 4 hr period. Dieldrin has a half-life of about 6 months, a volume of distribution of about 40 L/kg, and a dermal permeability of about 3 x 10° cm/sec. (a) Estimate the absorption rate during the exposure period assuming the blood concentration is much lower than the skin concentration (i.e., take the blood level to be zero in the skin absorption equation). (b) Estimate how it takes after exposure begins for the groundskeeper's plasma dieldrin levels to reach 1 ng/L. (c) Estimate the maximum plasma dieldrin concentration in ng/L that will occur in this groundskeeper due to this exposure. (d) Estimate how long it will take after exposure ends for the groundskeeper's plasma dieldrin levels to drop back down to 1 ng/L. %3D
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