Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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3.5 An a helical, intracellular protein, ITSME, denatures at 80 degrees Celsius. Which of the
following are true about ITSME?
Above 80 degrees Celsius, disulfide bonds break, destabilizing the protein.
Mutating 2 residues in an a helical part of ITSME to proline will likely decrease the
temperature at which ITSEME denatures.
At temperatures below 80 degrees Celsius, ITSME adopts a folded structure largely due
to the hydrophobic effect.
Increasing temperature provides sufficient kinetic energy to overcome the very large
free energy difference between the folded and unfolded states of ITSME.
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Transcribed Image Text:3.5 An a helical, intracellular protein, ITSME, denatures at 80 degrees Celsius. Which of the following are true about ITSME? Above 80 degrees Celsius, disulfide bonds break, destabilizing the protein. Mutating 2 residues in an a helical part of ITSME to proline will likely decrease the temperature at which ITSEME denatures. At temperatures below 80 degrees Celsius, ITSME adopts a folded structure largely due to the hydrophobic effect. Increasing temperature provides sufficient kinetic energy to overcome the very large free energy difference between the folded and unfolded states of ITSME.
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