3 1. PPh3 (1.0 equiv), 2. nBuli (1.0 equiv) 3. 3 O=PPh3 + LiBr

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Chapter1: Chemical Foundations
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The image depicts a chemical reaction mechanism commonly found in organic synthesis, possibly illustrating a Wittig reaction. Here is a transcribed and detailed explanation fit for an educational website:

---

### Reaction Mechanism Overview

**Starting Material**:

- The reaction begins with an unspecified substrate placed in a bounded rectangle marked by the number [3].

**Reaction Steps**:

1. **Reagents and Conditions**:
   - **PPh₃ (Triphenylphosphine), 1.0 equivalent**: This reagent is involved in the formation of a phosphonium ylide, a key intermediate in Wittig reactions.
   - **nBuLi (n-Butyllithium), 1.0 equivalent**: A strong base, n-Butyllithium, is used to deprotonate a phosphonium salt to form the corresponding ylide.

2. **Mechanism**:
   - An arrow is shown directing from the starting material to the products, indicating the progression of the reaction. The addition of PPh₃ and nBuLi facilitates the conversion of the substrate.

3. **Products**:
   - The structure on the right shows a cyclic compound with a double bond and a keto group, along with an alkyl chain. This product results from the reaction of the ylide with a carbonyl compound.
   - Additional by-products include **O=PPh₃ (Triphenylphosphine oxide)** and **LiBr (Lithium bromide)**.

The entire setup corresponds to a typical preparation and reaction sequence, effectively illustrating principles of organophosphorus chemistry and practical aspects of synthetic methodology in organic chemistry.

--- 

This mechanism is commonly featured in advanced organic chemistry courses and research settings, highlighting the utility and versatility of Wittig reactions in the synthesis of alkenes.
Transcribed Image Text:The image depicts a chemical reaction mechanism commonly found in organic synthesis, possibly illustrating a Wittig reaction. Here is a transcribed and detailed explanation fit for an educational website: --- ### Reaction Mechanism Overview **Starting Material**: - The reaction begins with an unspecified substrate placed in a bounded rectangle marked by the number [3]. **Reaction Steps**: 1. **Reagents and Conditions**: - **PPh₃ (Triphenylphosphine), 1.0 equivalent**: This reagent is involved in the formation of a phosphonium ylide, a key intermediate in Wittig reactions. - **nBuLi (n-Butyllithium), 1.0 equivalent**: A strong base, n-Butyllithium, is used to deprotonate a phosphonium salt to form the corresponding ylide. 2. **Mechanism**: - An arrow is shown directing from the starting material to the products, indicating the progression of the reaction. The addition of PPh₃ and nBuLi facilitates the conversion of the substrate. 3. **Products**: - The structure on the right shows a cyclic compound with a double bond and a keto group, along with an alkyl chain. This product results from the reaction of the ylide with a carbonyl compound. - Additional by-products include **O=PPh₃ (Triphenylphosphine oxide)** and **LiBr (Lithium bromide)**. The entire setup corresponds to a typical preparation and reaction sequence, effectively illustrating principles of organophosphorus chemistry and practical aspects of synthetic methodology in organic chemistry. --- This mechanism is commonly featured in advanced organic chemistry courses and research settings, highlighting the utility and versatility of Wittig reactions in the synthesis of alkenes.
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