21. The following is correct about superantigens? A. cause autoimmune disease C. activates B cells 22. Perforins and granzymes are synthesized by the following cell? A. TH1 B. Th2 C. macrophages 72 The foll B. activates many T cells D. are high molecular wt proteins D. CD8+ T cells
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- 45. Which of the following would be involved in reacting to a first-time exposure to Mycobacterium tuberculosis? a. a pre-7-10-day production of IgM b. activation of only T cells by T cells с c. memory B cells d. MHC I or II e. the macrophage as the first leukocyte arriving to the site of infection 46. The F region can do all the following except a. interact with pseudopods b. bind to B cells c. bind to T cells d. bind to pmns initiate endocytosis e. 47. Lysogeny can be linked to cervical cancer a. b. be linked to Streptococcus pneumoniae infections c. cause the production of a new bacterial strain d. be used as a possible cure for cancer e. all the above 48. Viruses that infect fungal cells probably recognize a. cholesterol b. ergosterol c. pencillin binding proteins d. DNA gyrase e. beta-lactamase 49. Which of the following would be an ineffective antiviral drug? a. one that blocks viral attachment b. one that inhibits viral nucleic acids replication c. one that destroys only the…12. The following does not participates in the intracellular activation of T cells? A. ITAM of CD3 B. ZAP-70 C. phospholipase gamma D. NF-AT transcription factor E. Ig alpha and beta 13. As a response to viral-infected cells, the following cell gets activated? B. TH2 C. TH3 A. TH1 D. TH1719. The following event does not occur in the germinal centers of activated B cells? A. somatic hypermutation. B. formation of memory B cells C. RNA recombination D. plasma cell formation 20. Features of T-independent immune response include? A. occurs in people that lack a functional thymus C. give rise to memory cells. 21 Thafall E. class switching B. production of IgG and IgA D. involve immunological synapse
- 1. Which of the following statements about CD4+ Th17 cells are true? i. Cannot form T effector memory (TEM) T cell populations ii. Require the master transcription factor RORgammaT for their development iii. Produce effector cytokines IL-17 and IL-22 which help recruit neutrophils and stimulate antimicrobial peptide production iv. Do not require the transcription factor NFAT for IL-2 production downstream of TCR activation v. Important for defense against intracellular bacterial infection only a. i and iii b. ii and v c. ii and iii d. ii, iii, iv e. i, ii, and iv1. which antibody isotypes is in lowest concentration in serum? a- IGA b- IgD c-IgG d-IgE e- IgM 2. A ruptured spleed was removed from a 37 year old car accident victim. what would be the consequences? a- lack of IgG producing B cells b- lack of IgA producing B cells c- Can't mature T cells d-Lack of IgG producing B cells e- can't activate macrophages14. Predominant cell types involved in the humoral immune response are: A. eosinophils. B. macrophages. C. neutrophils. D. B cells 15. T helper cells recognize which of the following? A. Exogenous peptide bound to class II MHC B. Native extracellular viral proteins C. Endogenous peptides bound to class I MHC D. Microbe-specific structures 16. How are cytotoxic T cells and natural killer cells similar? A. Both require antibędy to be bound to the target cell. B. Both induce apoptesis in the target cell C. Both recognize peptide plus MHC class I. D. Both kill target cells lacking MHC class I. 17. Perforin and granzymes are used by which cells to kill target cells? A. CD8 T cells and CD4 T cells B. CD4 T cells and natural killer cells C. Natural killer cells and B cells D. CD8 T cells and natural killer cells
- 16. Which cell type assist and interact with both humoral and cell-mediated immunity? A. Macrophages B. Cytotoxic T cells C. Memory T cells D. Helper T cells 17. Which of these cells are involved in cell-mediated immunity by destroying virally infected cells and rejecting organ transplants? A. Natural killer cells B. B cells C. Macrophages D. Cytotoxic T cells 18. Identify the junction between an axon and another cell. A. Synapse B. Presypnaptic cell C. Postsypnaptic cell D. Neurotransmitter29. T-cell dependent antigens can a. directly stimulate B cells to multiply and produce antibodies b. directly induce T cells to function с c. restrict antibody formation. d. directly activate macrophages e. directly activate Th cells 30. These are the normal ranges for IgG, IgM and IgA. IgG: 6.0 16.0 g/L; IgA: .8-3.0 g/L and IgM: .4-2.5 g/L. You measured these levels in your patient and received the following results: IgG: 10 g/L; IgM: 5.0 g/L and IgA: 1.5 g/L. Which of the following is a result of your patient's antibody levels? a. The presence of a high number of eosinophils b. The presence of a low number of basophils c. The presence of a high number monocytes d. The presence of a high number of natural killer cells e. The presence of a high number of pmns 31. T-cell independent antigens can a. directly stimulate B cells to multiply and produce antibodies b. directly induce T cells to function c. restrict antibody formation d. directly activate macrophages e. directly activate T₁…18. Antiviral proteins synthesized in response to the binding of interferon may target a. intracellular uncoating b. nucleic acid synthesis c. viral assembly C. d. viral ribosomes e. all the above except d 19. When a macrophage encounters S. aureus, which of the following will most likely not occur? a. The macrophage will indirectly induce the synthesis of an antibody b. The macrophage will activate T cells C. The macrophage will produce cytokines d. The macrophage will exhibit its phagocytic and antigen presenting traits e. a & b 20. Plasma cells are actually activated by a. an antigen b. a T cell c. a B cell d. a memory cell PRRS e. 21. Development of resistance to a particular antimicrobial is limited if the drug a. binds to several sites on the target molecule b. targets several different molecules c. affects only one molecule d. affects the plasma membrane e. a and b
- 1) Dysfunctional repair of DNA double strand breaks often results in SCID because: (Choose all that apply) DNA must be broken as part of B cell development. B cells fail to develop and instead die. а. b. С. DNA must be broken as part of T cell development. d. |T cells fail to develop and instead die.22. Which of the following is NOT a characteristic of cell- mediated immunity? a. The cells originate in bone marrow b. Cells are processed in the thymus gland c. The activation of cell-mediated immunity can be suppressed d. They are antigen presenting cells e. All of the above are characteristics of cell-mediated immunity 23. All of the following could be possibly target sites for antimicrobials to limit the possibility of side effects except a. peptidoglycan b. parasitic glycolytic enzymes c. ergosterol C. d. RNA polymerase DNA gyrase e. 24. Lysogeny can result in all of the following EXCEPT a. persistent infections b. a bacteria expressing new genes c. transduction of genes C. d. the turning off of the host cell's transcriptional and translational machinery e. the definite destruction of an infected cell 25. Due to your patient's opsonization of a bacterial cell with C₂B, which of following did NOT occur a. interference of the patient's secondary viral infection b. bacterial cell…32. Antibiotics that affect various strains of Gram-positive bacteria and various strains of Gram-negative bacteria are considered to be a. isolate usable b. stress-induced spectrum c. narrow spectrum d. broad spectrum e. major spectrum 33. Aspirin is considered to be an anti-inflammatory drug. Therefore, it would block which of the following? a. C3₂ b. perforins c. MHC I d. C3, e. Co 34. Which of the following characteristics is shared by innate and adaptative immunity? a. first line of defense b. skin c. complement d. production of lysozyme e. production of molecules that prevent attachment of the microbe to host cells