2. Give the pK₂ values for the following compounds and then rank them in terms of increasing acidity. Explain why the values change so dramatically (each pKa unit is an order of magnitude) from one member of the series to the next. NH3 HF CH4 H₂O

One of the steps in fat metabolism is the hydration of crotonate to yield 3-hydroxybutyrate. This reaction occurs by addition of —OH to the Si face at C3, followed by protonation at C2, also from the Si face. Draw the product of the reaction, showing the stereochemistry of each step.

Draw the structure of the predominant form of CF3CH2OH (pK a = 12.4) at pH = 6.

What is the correct answer and why?

5. Which of the following equations shows that isoquinoline, C9H;N, behaves as a Bronsted-Lowry base in water? a) CóH;N(aq) + H2O(1) = b) CH;N(aq) + H2O(1) c) C9H;N(aq) + OH¯(aq) = d) CoH;N(aq) + H;O*(aq) e) CoH;NH*(aq) + H2O(!) C9H;NH*(aq) + OH (aq) = C9H&N°(aq) + H;O*(aq) C9HN¯(aq) + H;O(!) = C9H;NH*(aq) + H2O(1) = C9H;N(aq) + H;O*(aq)

The pKa values of the two ammonium cations drawn below are 8.33 and11.1. Which pKa corresponds to which cation? Explain your choice.?

Provide pka (in scale of 5) of the o-Hydrogen on both compounds. pKa b) a) CH2 А pKa CH2

what is the meaning of "7H" in 7H-purine?

Base on the given pka and structure of the vitamin A, predict what would happen to the message written in NaNH2 (pKa 38) when sprayed with vitamin A? Compound NH3 Conjugate base NH2 pka 38 Select one: OH Vitamin A a. Invisible. Reaction is reactant favored O b. Invisible. Reaction is product favored but no resonance structures ○ c. Visible. Reaction is reactant favored O d. Visible. Reaction is product favored Which of the following base is strong enough to deprotonate ethanol? 16

Explain why cyclopentadiene (pKa = 15) is more acidic than pyrrole (pKa ∼17), even though nitrogen ismore electronegative than carbon.