2. Draw the mechanisms for the following: ö: H-C: H-Br: K+ Н. :0

109. Subject  :- Chemistry

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Please

(18). Subject:- Chemistry

a. Delta H < 0 b.) Delta H > 0 c.) Need more info d.) Delta H = 0

Please give a reasonable mechanism for the following reaction using a carbene or related intermediate. Please draw it out and write out the steps. PLEASE SHOW WITH ARROWS. C m-CPBA (1.0 equiv) CH₂Cl2, 0 °C, 1h then, Ph3AuNTf2 (5 mol %), 1 h 85%

(ii) (iii) Shown below is a redox activated prodrug 1 for gene-directed enzyme prodrug therapy (GDEPT) where E. coli nitro reductase gene has been introduced to the cancer cells. Show both the mechanism of conversion of the prodrug and the products that will be produced when the prodrug is acted on by E. coli nitro-reductase. [15 marks] NO₂ NO₂ OH Compound 2 below was also prepared as a potential redox activated prodrug for GDEPT. However, the biological activity of 2 was very poor compared to 1. Explain the difference in the observed biological activity between 1 and 2. [10 marks] OH NH 2 NH