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18. Explain why the Krebs cycle can be referred to as the final common pathway of the
degradation of organic compounds.
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- 8. In patients with diabetes mellitus type 1, the biochemical disorders result from changes in fuel metabolism. One of these signs is acidosis, Explain why such patients have a deviation of blood pH from the norm? For this 9. b) write the reactions of synthesis and oxidation of these molecules, name the enzymes, coenzymes, reaction localization: X6. Suggest a name for an enzyme that catalyzes each of the following reactions. a.) Oxidation of nitrite b.) Decarboxylation of citrate c.) Reduction of oxalateT8. In patients with diabetes mellitus type I, the biochemical disorders result from changes in fuel metabolism. One of these signs is acidosis. Explain why such patients have a deviation of blood pH from the norm? For this: b) write the reactions of synthesis and oxidation of these molecules, name the enzymes, coenzymes, reaction localization;
- Describe the following through Venn diagram a) Alcohol fermentation and Lactate fermentation. b) DNA polymerase and RNA polymerase c) Active site and allosteric site5. Gout can be caused by superactivation of PRPP synthase, or partial deficiency of hypoxanthine-guanine phosphoribosyl transferase. Why the change in these enzyme activities can induce the development of this disorder? For the answer: a) write down the scheme of the reactions catalyzed by these enzymes;b) specify metabolic pathways these reactions take part in; c) answer the main question of the problem.8. Structures of three coenzymes involved in Phase II conjugation reactions are shown below. For each coenzyme, circle the portion of the coenzyme that is transferred during metabolic reaction. NH, CH NH, COO CH, H2C OH CH НО O-UDP HC H H ОН он он UDP-Glucuronate S-Adenosylmethionine (S-AdoMet) SCo AcetylSCo
- Explain why the ability of some microorganisms to produce β-lactamase present prior to their exposure to the antibiotic penicillin3. b. If chymotrypsin is treated with disopropylfluorophosphate, catalysis cannot occur even in the presence of excess substrate concentration. Is this Inhibltion reversible or Irreversible?. Dilsopropylfluorophosphate HydExplain the concept of redox balance. What conditions must exist,for example, for cytochrome oxidase to be in redox balance?
- 1. In a catabolic pathway, metabolite X gets converted into metabolite Y, metabolite X 0 J mol-¹ and AG' is <0 J mol-¹ for this reaction. a) At standard states, is this reaction favorable? b) Is the reaction favorable or unfavorable at cellular condition? c) Is this an endergonic or exergonic reaction in the cell? d) Would you describe this as a thermodynamically downhill or uphill reaction in the cell?Part A. If you were to expose cells that are undergoing anaerobic respiration to a radioactive carbon isotope in the form of C6H12O6C6H12O6, which of the following molecules would you not expect to be radiolabeled? a)pyruvate b)succinyl CoA c)fructose-1,6-bisphosphate d)lactate Part b.If you were to expose cells that are undergoing aerobic respiration to a radioactive carbon isotope in the form of acetyl-CoA, which of the following molecules would you not expect to be radiolabeled? a)oxaloacetate b)succinyl CoA c)pyruvate d) CO210. what is the key enzyme of the pentose phosphate pathway also serving as the first enzyme of the oxidative phase of the said pathway yielding 6-phosphogluconate? please do not abbreviate