15) The discontinuous aspect of replication of DNA in vivo is caused by ________. A) topoisomerases cutting the DNA in a random fashionB) polymerase slippageC) trinucleotide repeatsD) sister-chromatid exchangesE) the 5′ to 3′ polarity restriction why E is correct answer

Xeroderma pigmentosum is a genetic disease caused by an error in the nucleotide excision repair process that fixes damage to DNA by ultraviolet light.  Studies have shown that it can result from mutations in any one of seven genes. What can you infer from this finding?   A) There are seven genes that produce the same protein B) These seven genes are the most easily damaged by ultraviolet light. C) There are seven enzymes involved in the nucleotide excision repair process. D) These mutations have resulted from translocation of gene segments.

You discover an E. coli mutant that has a non-functional DNA polymerase III. Such a bactèria; a) Would not be able to synthesize new strands of DNA b) Would not be able synthesize the leading strand of DNA Oc) Would produce new strands of DNA still containing short RNA primers Od) Would be able to synthesize the lagging strand of DNA only

Which of the following is not a DNA repair mechanism? a) binding-protein excision repair b) nucleotide excision repair c) mismatch repair d) base excision repair

How many unique primers are required to amplify a single DNA target region?   a) 1 b) 2 c) 4 d) number varies according to length of target region

A DNA polymerase enzyme inherently incorporates an incorrect nucleotide at a low but measurable rate. Such a mutation is termed _______. A)  spontaneous B)  lysogenic C)  transformative D)  transductive E)  induced

Double-stranded breaks are repaired by     a)  homologous recombinational repair.   b)  translesion repair.   c)  direct reversal of DNA damage

Replication slippage can cause indels in repetitive regions of DNA. Which of the following statements is not true?a) slippage of the new daughter strand causes repeat expansionb) slippage of the template strand causes repeat deletion c) slippage can cause indels on either the daughter or the template strandd) the indel mutation becomes fixed in one daughter cell's genome only after the next round of replication e) none of the above (all are true statements)

Which of the following typically causes chromosome mutations such as inversions and translocations? A) Base modifiers B) UV light C) ionizing radiation D) base analogues E) intercalating agents

A temperature sensitive mutant is isolated where at the non-permissive temperature replication stops relatively slowly and when the DNA is analyzed it appears to have extra twists ahead of the replication forks.  What protein is most likely mutated? a)DnaA b)DNA polymerase I   c)DNA gyrase   d) DNA polymerase III