[1] (R)-CBS reagent Nal CH3NH2 [1] NaH duloxetine [2] H20 [2] :O

Organic Chemistry
9th Edition
ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter24: Amines And Heterocycles
Section24.SE: Something Extra
Problem 40MP
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Several steps in the synthesis of optically active duloxetine, an antidepressant sold under the trade name Cymbalta, are shown. Identify the structure of intermediates A–C and the final product duloxetine, including stereochemistry, in this reaction sequence.

[1] (R)-CBS reagent
Nal
CH3NH2
[1] NaH
duloxetine
[2] H20
[2]
:O
Transcribed Image Text:[1] (R)-CBS reagent Nal CH3NH2 [1] NaH duloxetine [2] H20 [2] :O
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