Results 1. There was no mortality in animals treated with poly herbal capsules at concentrations of 5 g; 2.5 g and 1g /kg. body weights for 14 days. This indicates that poly herbal capsules even at very high concentrations was not lethal to rats. 2. Necropsy of the animals after sacrifice did not show any morphological changes in the tissues nor any gross pathological abnormalities (Fig.1). 3. Acute administration of poly herbal capsules at doses 5g/kg,2.5g/kg and 1g/kg. Body weight did not produce any decrease in the body weight of adult male and female Wistar rats used in this study (Fig.2 and Fig.3). This indicates that concentrations much higher than the effective dose in humans did not produce any toxicity to rats as seen from weight …show more content…
Administration of 4-Plus capsules for 14 days did not produce any change in the renal function tests such as urea and creatinine which was similar to that of controls. This indicates that poly herbal capsules did not produce any toxicity to kidney and other renal tissues at concentrations studied here (Table 3). 9. Administration of poly herbal capsules did not produce any change in serum electrolytes such as sodium, potassium, chloride and bicarbonate indicating a normal electrolyte balance is maintained during poly herbal capsules administration (Table 4). 10. Administration of poly herbal capsules for 14 days at very high concentrations did not produce any change in haematological parameters in the animals such as total WBC, RBC, Platelet, haemoglobin as well as in the differential count. This again indicates that poly herbal capsules at high concentrations was not toxic to haematological system (Table 5 and Table 6). 11. Administration of 4-Plus capsules did not produce any change in cholesterol levels, HDL, LDL ,VLDL & triglycerides, which was almost normal. This indicates that poly herbal capsules did not effect lipid levels in the animals (Table 7). 12. Histopathology (Fig.8) Normal …show more content…
Hepatocytes show normal morphology. Sinusoidal spaces and Kupffer cells appear normal. Treated Liver Section of Liver shows normal portal triads and central nervous system. Hepatocytes show normal morphology. Sinusoidal spaces and Kupffer cells appear normal. Normal
There are many herbal treatments available to patients, but few have been used longer than sambucas nigra, otherwise known as elder berry. Well known for its analgesic, antipyretic, anti-inflammatory, diuretic, laxative immune boosting qualities, elder berry has been used for multiple health alterations (Ulbricht, Basch, Cheung, Goldberg, Hammerness, Isaac, &...Wortley, 2014). In this paper the background, pharmacology, contraindications, current research and recommendations for use regarding elder berries will be discussed. Elder berries are a versatile fruit that has multiple applications in the healthcare field, warranting an increased role in patient care.
Recent studies in animals and in humans have shown that increased intake of polyphenols may:
Treatment for Cancer: Yunzhi mushroom supplements – traditional med used by doctors in China for 2,000+ years –were reported in clinical trials to provide a longer survival
The fact must be faced; obesity is increasing in numbers. However, it is interesting to note that as the number of overweight individuals increases, so too does the various methods of reducing caloric and fat intake. In today’s busy society Americans are willing to try almost any weight loss product on the market in order to reach their goal of "thinness. Americans are turning to herbal supplements in record numbers as a means of attaining their dietary needs and goals. One of the best selling herbal supplements on the market is Metabolife 356â (http://www.metabolife.com/news/100199.htm).
The extraction of the active constituents from the leaves by chewing is very effective with only 9.1% remaining as a residue after chewing. The second adsorptive segment is the stomach and small intestine (Toennes et al.,
Both crude and processed aloe vera was shown to increase average life span of Fischer 344 rats by 10%. Group 2 and 3 had a lower incidence of atrial thrombosis than than the control group 1. Moreover, Group 2 has a significantly lower occurence of fatal chronic nephropathy and of multiple causes of death in comparision to the control group 1. Moreover, no adverse, toxic effects were found with the ingestion of aloe vera.
It was found that chewing naturally occurring khat leaves does not lead to many toxicity repercussions, due to such a low concentration of the active psychostimulant being present (9). But with synthetic cathinones, high concentrations of the active
One of the best examples of herbal remedy use in Western Medicine would be the use of Opium in pain treatment. Opium is made by drying the “tears,” or latex from a opium poppy (Papaver somniferum) bulb before becoming mature. By cutting the bulb, the latex seeps out, therefore producing a solution containing various substances, most notoriously, the 12% by volume of alkaloid morphine, which is used as a method of chronic pain treatment, as well as the production of heroine. It was originally used in the 16th century to induce sleep and relieve pain, and was introduced to western medicine by a man of the name Paracelsus. It was only after reading the Pseudo-Apuleius Herbarius book, a collection of herbs names and diseases, that he managed to
Sometimes called botanicals, herbal supplements are one type of dietary supplement that have been around for thousands of years. They may not have been in fancy packaging back then, put many important plants have long been used for medicinal purposes. These herbal medicines occur naturally and are used to treat a number of ailments according to the benefits that different plant provides. Whether it’s a cold, pain, skin disorder, swelling, or some other form of ailment, herbal supplements, such as borage oil, cat’s claw, cayenne pepper and Echinacea are great natural treatment options for healing the body and alleviating common health issues.
Prescription medication is an important part of healthcare and a must have for patients because it helps manage a lot of symptoms and diseases. It can help kill bacteria causing patients to feel ill, it can also reduce pain and suffering for others. However, most mediations have some type of adverse side effects as it is made from chemicals processes or extracts from herbal plants. There are contraindications and cautions to every medication in which we have to be aware of when prescribing the medication; there is also drug to drug interactions that may occur. To help prevent medication errors we can use online resources to look for any drug to drug interactions and contraindication/adverse effects. We also need to stress the importance
Often the socially held idea of someone using herbal supplements is either the muscled fitness devotee or the earth sensitive “hippy” weary of medical science. This is both inaccurate and a dangerous stereotype that anesthesia clinicians should be careful not to believe. In truth the average herbal supplement user is between 40 to 60 years old and a higher prevalence of female gender.7 Though do not be deceived by those generalizations, as the gamut of daily users
Herbal medicines are great alternative for commercially manufactured medicines available in the market. The major reason why herbal medicine differ from modern medicine is because they are produced with 100% natural content. Therefore the plant extract has all the medicinal values that are as effective as modern medicine. Commercially prepared drugs show results quickly but have numerous side effects. However herbal medicines don’t show any side
Today, since more and more people are living in urban areas, medicinal plants, supplements, herbal capsules, fruits, vegetables, and spices can easily be acquired in local supermarkets, thus making herbal medicine available anywhere. Even in the rural areas, access to this kind of medication is easy since they are closer to nature. People can also grow herbs in their own land. Questions arise whether the quantity and quality of these medicines and its origin is suitable and enough to supply the growing population. Because the Food and Drug Administration tightly regulates the pharmaceutical industry, there are simply far more herbal medicine products available for consumption.
Research showed that plant containing flavonoids, saponin, and tannin are useful in many CNS disorders same reflected in S.asoca. This may be the probable reason for the sleep and lethargy in animals (Verma et al.; 2010). No significant changes were seen in their food–water intake and utilization of food indicating normal metabolism in the animals. The reduction in body weight gain and internal organ weights is a simple and sensitive index of toxicity after exposure to toxic substance (Raza et al., 2002; Teo et al., 2002). There were no significant differences in body weight gain or internal organ weight such as liver, lung, heart, spleen, kidney and brain when compared with the control group. Moreover, gross morphological examinations of the internal organs revealed no abnormality.
Herbal medicine means usage of plants for the promotion of healing and maintenance of health. The knowledge of traditional medicine and use of plants as medicine is the important component of healthcare system. Natural resources are very rich in India. About 1,500 medicinal plants are identified and of which 500 plants are commonly used [h-d (2007), (2001)3]. Today most of the people use herbal drugs along with prescription and non prescription drugs. Although they are considered as natural many of them interact with other medications and cause either dangerous side effect and / or reduced benefits from the medications. Presently, a very little information published on herbal drug interactions even though, the use of herbs is progressively