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Wistar Study

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Results 1. There was no mortality in animals treated with poly herbal capsules at concentrations of 5 g; 2.5 g and 1g /kg. body weights for 14 days. This indicates that poly herbal capsules even at very high concentrations was not lethal to rats. 2. Necropsy of the animals after sacrifice did not show any morphological changes in the tissues nor any gross pathological abnormalities (Fig.1). 3. Acute administration of poly herbal capsules at doses 5g/kg,2.5g/kg and 1g/kg. Body weight did not produce any decrease in the body weight of adult male and female Wistar rats used in this study (Fig.2 and Fig.3). This indicates that concentrations much higher than the effective dose in humans did not produce any toxicity to rats as seen from weight …show more content…

Administration of 4-Plus capsules for 14 days did not produce any change in the renal function tests such as urea and creatinine which was similar to that of controls. This indicates that poly herbal capsules did not produce any toxicity to kidney and other renal tissues at concentrations studied here (Table 3). 9. Administration of poly herbal capsules did not produce any change in serum electrolytes such as sodium, potassium, chloride and bicarbonate indicating a normal electrolyte balance is maintained during poly herbal capsules administration (Table 4). 10. Administration of poly herbal capsules for 14 days at very high concentrations did not produce any change in haematological parameters in the animals such as total WBC, RBC, Platelet, haemoglobin as well as in the differential count. This again indicates that poly herbal capsules at high concentrations was not toxic to haematological system (Table 5 and Table 6). 11. Administration of 4-Plus capsules did not produce any change in cholesterol levels, HDL, LDL ,VLDL & triglycerides, which was almost normal. This indicates that poly herbal capsules did not effect lipid levels in the animals (Table 7). 12. Histopathology (Fig.8) Normal …show more content…

Hepatocytes show normal morphology. Sinusoidal spaces and Kupffer cells appear normal. Treated Liver Section of Liver shows normal portal triads and central nervous system. Hepatocytes show normal morphology. Sinusoidal spaces and Kupffer cells appear normal. Normal

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