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Tp Lung: How Uranium Enters Our Body

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Discussion:
From reading and studying many articles I have learned that when heavy toxic materials enter our bodies, it causes TP53 to become active. When uranium enters our body, it is more dangerous than the other materials (chrome, Cd, mercury & lead), because it does the exact opposite. It makes TP53 inactive rather than active, as a result it causes cancer. Because of this TP53 can’t fix the damage uranium has done, since it is inactive. Consider this, there is no known solution for this specific problem. Over the course of time researchers have tried numerous times to discover a solution for uranium poisoning. Eventually, researchers have discovered various techniques to detect and remove uranium toxicity from the body. First, the …show more content…

When uranium enters our body through inhalation, the uranium has the ability to dissolve within the lungs, which can lead the uranium to be transported by the blood to other parts of the body such as the spleen, brain, kidney, and other organs. Uranium can remain within the kidney and brain for a significant amount of time because of its high concentration, while remaining for a shorter period of time within the plasma. A previous study on the action of salt has lead researchers to discover that sodium bicarbonate and sodium citrate can lessen the toxicity of uranium. Citric acid and citrate salts have the ability to protect the body from uranium toxicity with possible side effects such as diarrhea and nausea. While researchers have tried to develop different methods to reduce or remove uranium toxicity, not all chelating compounds can treat uranium effects [3]. These researchers have found that some metals have many biological functions in contrast to uranium which has limited biological activity. Considering that many researches focus on the biological aspect to find ways to remove heavy metals such as uranium, this has led to the detection of the uranyl species and treatment of radioactive waste. Because of this few bacteria have the ability to reduce the oxidation state of uranium in salts such as soluble +6 oxidation to

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