The Sickle Of Sickle Cell Disease

Sickle Cell Disease is an illness that affects people all across the globe. This paper will give a description of the sickness through the discussion of the causes, symptoms, and possible cures. Sickle Cell Disease (SCD) is a "group of inherited red blood cell disorders."(1) These disorders can have various afflictions, such as pain, damage and a low blood count--Sickle Cell Anemia.

Sickle cell anemia is a hereditary disorder that mostly affects people of African ancestry, but also occurs in other ethnic groups, including people who are of Mediterranean and Middle Eastern descent. More than 70,000 Americans have sickle cell anemia. And about 2 million Americans - and one in 12 African Americans - have sickle cell trait (this means they carry one gene for the disease, but do not have the disease itself).

This mutation paper is to give information on the Sickle Cell disease. This is a negative disease to have because the Sickle Cell Disease decreases the health of the person that has the disease and limits what they can and cannot do. Sickle Cell Disease is a red blood cell disease that causes ab normal hemoglobin to from in the veins. Hemoglobin is the protein that carries oxygen throughout the body to help with the respiratory system. The cause of the genetic mutation is inheritance or getting the disease from the parents the disease is found on chromosome 13 while the hemoglobin is still in beta phase on gene HB A. The disease typically shows symptoms within the first 5 to 6 months of birth and being diagnosed with Sickle Cell Disease. The symptoms include painful swelling on the hands and feet, and Jaundice, which causes a white color to form under the eyes, and turns the skin color yellow.

The sickle cell disease affects about 100,000 people in the America. The most common ethnic group the sickle cell anemia is seen in is African Americans and Hispanics. Approximately one in every ten African American and one in every one hundred Hispanic Americans have the sickle cell trait. Approximately two million people have the sickle cell trait in America. Approximately one in five- hundred African Americans and one in one thousand to one thousand and four hundred Hispanic-Americans have sickle cell disease. No universal cure has been found for sickle cell anemia (“Facts About Sickle Cell Trait And Disease,”n.d.). Sickle cell anemia affects many Americans and a universal cure needs to be found.

Sickle cell anemia is an inherited disease causing red blood cells to malfunction. It is a disorder the affects hemoglobin the protein found in red blood cells. People with this disease genetically inherit this untypical hemoglobin. This means that it cannot be transmitted from one person to another like the flu virus. These people have what its called hemoglobin (s). What this does is that instead of the red blood cell being circle-shaped it would appear to be a half moon shaped cell. It is necessary for the cells to be round so that they would be able to pass though small and large blood vessels.

While people are trying to find a breakthrough cure for diseases such as Cancer, Sickle Cell patients feel that they are left in the dark of the public’s eye. Each day thousands of people are being faced with the shocking truth of having to live a very hard, tiresome, and very painful life. According to researchers about one in four hundred African American is affected with Sickle Cell. Therefore it is felt that there should be a greater effort in trying to find a cure for this disease.

Sickle Cell Disease is a genetic disease. If you have the disease, you have a lower life expectancy while you are also given a tremendous amount of pain to endure. The disease is inherited and it also causes a mutated hemoglobin. When you have this disease, instead of your red blood cells being circular like a moon it is much smaller like the shape of a crescent moon. Our red blood cells

In high-income countries like the United States, the life expectancy of a person with SCD is now about 40–60 years. In 1973, the average lifespan of a person with SCD in the United States was only 14 years. Advances in the diagnosis and care of SCD have made this improvement possible. Sickle Cell disease affects mostly African, Mediterranean and related ancestries it is passed on through generational traits and common related blood type. Sickle Cell disease is a disease that causes painful attacks called crises; which causes throbbing in their bones and backs. Sickle cell is caused by a protein that is abnormal called hemoglobin S which causes the shape of red blood cells to change into a sickle or crescent type shape. (George Buchanan, 2010) Cells in tissues need a steady supply of oxygen to work well. Normally, hemoglobin in red blood cells takes up oxygen in the lungs and carries it to all the tissues of the body. Red blood cells that contain normal hemoglobin are disc shaped (like a doughnut without a hole). This shape allows the cells to be flexible so that they can move through large and small blood vessels to deliver oxygen. Sickle hemoglobin is not like normal hemoglobin. Sickle-shaped cells are not flexible and can stick to vessel walls, causing a blockage that slows or stops the flow of blood. When this happens, oxygen can’t reach nearby

In conclusion, sickle cell disease and sickle cell trait have their advantages, but at the same time have many other downfalls that come along with having one of the two. People with sickle cell disease have hard lives, and have trouble doing everyday things like participating in a gym class, or doing any type of sports or physical activity. Although, people with only sickle cell trait, have the ease of not having to worry about malaria, but also run the risk of passing the disease to their children. Sickle cell disease is a serious problem worldwide, and it helps to be informed about

Sickle cell anemia is a disease passed down through families in which red blood cells form an abnormal crescent shade red blood cells are normally shaped like a disc. Sickle Cell anemia symptoms usually don 't occur until aged four months, almost all patients with

There are sometime not proper red blood cells to carry suitable oxygen in your body. Anemia is a genetic form by sickle cell anemia. Usually, red blood cells are elastic which can move and round nicely in blood vessels. If there will be any problem in as sickle cell anemia, then red blood cells changed into an inflexible. If sickle cell will be inflexible than cells cannot move blood one to another place perfectly. Red blood cells convent as gluey and looks as sickles or crescent moons. When cells shape will be unevenly than unevenly shaped cells create problems for blood vessels. These unevenly formed cells can have stuck in tiny blood vessels. These can be slow or block blood flow and oxygen to parts of body which is so necessary for human body. These makes healthy to human body. These are number of people who has sickle cell anemia. There is treatment which is provide relieve from pain and avoid difficulties. Which are related with this disease.

Sickle cell anemia is blood disorder characterized by red blood cells assuming a sickle shape. Ordinary small changes in red blood cell shape would not adversely affect the individual. However, due primarily to the excessive shape changes in the red blood cell; complications can arise within the individual. By forming a sickle shape, the red blood cell loses a disproportionate amount of its flexibility due a hemoglobin mutation. Normally, red blood cells are very elastic. This allows them to easily and seamlessly matriculate through the capillaries of the blood system. In sickle cell disease, low oxygen tension promotes red blood cell sickling. After repeated bouts of low oxygen environments the cells fail to return to normal shape when normal oxygen tension is finally restored. This then presents complications as the red blood cells can not matriculate through the capillaries. Due to this mutation complications arise the ultimately shorten the individuals lifespan. For example, as of 2008, the life expectancy of an individual infected with sickle cell anemia is roughly between 60-65 years of age. This is in stark contrast to an ordinary human being who is expected to live roughly 80 years. Various complications can occur that often shorten the lifespan of those who carry the gene. Complications include vaso-occlusive crisis which is caused by red blood cells restricting blood flow through the capillaries

Sickle cell anemia (SCA), also known as HbSS disease, is a common life-threatening inherited blood disorder in the world. It is widespread in Africa, Italy, Greece, Turkey, India, and Saudi Arabia. Sickle cell disease was reported In Saudi Arabia for the first time in the 1960s. Although the rate of patients who suffer from sickle cell disease in Saudi Arabia is not clear, it varies according to the different provinces. The highest rate of patients is in the Eastern and southwestern provinces. This triggered the scientists to improve the Sickle cell anemia’s health care, determine the disease characteristics and amplifications, manage and control the symptoms, and limit the number of patients.

Approximately 70,000-100,000 Americans have sickle cell anemia, the most common form of an inherited blood disorder that causes the production of abnormal hemoglobin, a protein that attaches to oxygen in the lungs and carries it to all parts of the body.1 Sickle cell anemia is a inherited disorder which causes the manifestation of unreliable hemoglobin resulting unevenly shaped red blood cells, recognized as "sickle cells." People with sickle cell disease have red blood cells that have mostly hemoglobin S, an irregular type of hemoglobin opposite of what a person has without this disease. Sometimes these red blood cells become sickle-shaped like a moon crescent and have difficulty passing through small blood vessels under

Sickle Cell Anemia is a group of disorders that cause red blood cells to become misshapen and break down. Sickle cell disease is the most common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans (Ashley-Koch, Yang and Olney). Sickle Cell Anemia causes your red blood cells to be thin, stiff, and shaped like a sickle. But your red blood cells are supposed to be round and soft. A person that is diagnosed with sickle cell anemia, their blood cells start to become clogged, causing blood clots, which can cause a great amount of health issues including: infections, stroke, and acute chest syndrome. People get sickle cell anemia by inheriting a mutated gene from both of their parents. On the down side, there is not currently an effective cure for sickle cell anemia, there are several different therapeutic approaches to treating and attempting to cure the disease and help people who are affected with sickle cell anemia better manage their symptoms. There have also been several great scientists that dedicated a lot of research to help find a cure for sickle cell anemia.