The Power To Edit Genomes Quickly And Effectively Is Here

Victor Frankenstein may have created and abandoned a creature, but what happens when you start to design future generations? Any scientific advancement that can have such a great effect on the lives of people has a possibility to be misused. Something as large as genome editing can be extremely useful, life changing, and effect every future generation. Then again, with great power comes great responsibility. Will genome editing be the modern Frankenstein?

For many years biomedical researchers like myself have been trying to create more proactive ways to amend the genome for living cells. In more recent fieldwork studies there has been a new state of the art instrument based on bacterial CRISP in close works with protein 9 often referred to as CAS9 from the streptococcus progenies have possibly unlocked new data. The CRISP/CAS9 tries to manipulate the function of the gene using homologous recombination and RNA interference, but is set back because it can only provide short term restriction of the genes function and it’s iffy off- target effects.

An idea that once seemed like mere science fiction is now, ever closer to becoming a reality thanks to advances in genetics, and the development of a gene editing technology called Crispr-Cas9, in 2012, which uses natural enzymes to target and snip genes

In “Life the Remix,” Alice Park discusses the impact and influence CRISPR has on science as well as its potential and risks. CRISPR—“clustered regularly interspaced short palindromic repeats”—is a technique to alter DNA, virtually for anything involving DNA. Although there have been attempts to edit DNA, none were as cheap and simple as CRISPR. This technique, which is based on the immune system of a bacetria, revolutionizes genetics after the subsequent discoveries of the molecular scissors enzyme: Cas9 and a method to efficiently and accurately edit human DNA using CRISPR, explains Park.

There are other types of gene editing out there but research shows us that CRISPR is fast, precise, and simple. Researchers are developing a way for CRISPR therapy to help with Alzheimer’s all the way to HIV. There are two categories the researchers and people have put CRISPR in: practical and philosophical. The researchers say that the immediate barrier is practical. During the tests, CRISPR has found targets in other parts of the DNA that need fixing other than the intended part of the DNA. Because of this, it may take at least a generation to ensure that it is safe. Some people oppose CRISPR because the oppositionists say it lets people play god but getting medicine every time you get sick with the same thing obscures the natural order of things. The opportunities are getting pushed ahead for treating cancer, childhood diseases that are genetic, and how to understand diabetes better. The one question some people have is whether it’s right to edit genes that are

The Gene Hackers published by the New Yorker’s Michael Specter talks about a breakthrough technology that could allow for the creation of genetically modified humans- “humans 2.0” as he calls it. This new technology could also be the cure for many genetic disorders like Alzheimer’s, Huntington’s etc. as it would allow scientist the ease of genetically identifying and editing specific genes responsible for these genetic abnormalities. This exciting new technology will be known as Clustered Regularly Interspaced Short Palindromic Repeats associated protein 9 or CRISPR-Cas 9 for short.

Every few years, advancements in technology alter the way scientists do their work. Recently CRISPR-Cas9, a RNA useful for working organisms in the animal kingdom has proven itself beneficial on a gene-editing platform. After performing many abortive attempts to manipulate gene function, including homologous recombination and RNA interference, scientists have finally had a breakthrough with CRISPR-Cas9.

Genetic diseases and illnesses have been of much concern for many years, leaving many deceased or with a poor quality of life. Due to the implication of modern medicine and other techniques used for treatments, mortality rates have decreased and the average life expectancy has increased. Unfortunately, every individual responds differently to the type of treatment they need, which is why the implication of personalized medicine is forthcoming. A certain technique that has been distinguished and commended by researchers today is known as clustered regulatory interspaced short palindromic repeats, or CRISPR. CRISPR is associated with Cas9, and it is a popular genome editing technique which can be programmed to target specific areas of DNA and

Granted there have been other gene editing techniques used before, but by far CRISPR has been reported to have the most potential to revolutionize different areas where the method is applicable. The fields that researchers believe these modification resources will be the most beneficial, include but are not limited to medicine for curing and preventing diseases, creating socially ideal children, and perhaps aiding in the decrease of world hunger. While these goals do seem quite optimistical, scientists have high hopes for what CRISPR will be able to accomplish with time. Currently the system is just now being tested out on living organisms, with the ambition of figuring ways to genetically terminate diseases (2).

First, I will make the most of my education, so that I can be better equipped to help others in the future. I would like to go through medical school and continue my educational path into research. There have been major advancements in gene-editing technologies such as the CRISPR Cas9 system, which, once improved, could revolutionize the science of medicine. This system was developed from the immune systems of bacteria, and works by using homology-directed repair or/in addition to non-homologous end joining to delete portions of DNA. Cas9 is a protein that couples with an RNA sequence to form a complex, which searches through DNA and looks for a DNA sequence to match the RNA one. Once it finds it, Cas9 cuts

The ability to engineer biological systems and organisms has an enormous potential for applications across basic science, medicine and biotechnology. Genome editing is a group of technologies that allow scientists the ability to change an organism’s DNA, which can provide better outcomes for health and disease control compared to natural immunity and mutations. Genome editing (gene editing) allows genetic material to be added, removed or altered at particular locations in the genome. A number of gene editing technologies have emerged in recent years with one of the most versatile and precise methods of genetic manipulation being Crispr-Cas9 (Steve scott,2016). The term Crispr-cas9, (clustered regular interspaced short palindromic repeats)

Genetic engineering is a very controversial topic. People either agree with genetic modification, or they don’t. According to dictionary.com, genetic engineering is the development and application of scientific methods, procedures, and technologies that permit direct manipulation of genetic material in order to alter the hereditary traits of a cell, organism, or population. While researching this topic, I learned many interesting facts. I found out that genetic engineering first started in 1973, I did not know it had been around for so long. I learned that two men, Herbert Boyer and Stanley Cohen, were the first people to genetically modify an organism, which was bacteria. Yourgenome.org states that, “Genetic engineering can be applied to

Crips stands for is Clustered Regularly Inspected Short Palindromic Repeats. What crispr does is for example with viruses and bacteria, bacteriophage will insert their own DNA into the bacteria the bacteria will try to defend themselves from this but most of the time the bacteria will not be able to defend themselves. What crispr does is that it will save the viruses DNA and the bacteria will make a RNA copy of the DNA and that DNA will go into the Cas9 in the Cas9 what will happen is that it will look for the DNA that will match the virus’s DNA and when it finds a match it will remove it and cut off the DNA so it protects the bacteria.

Genome editing is a huge leap forward in science and medicine. Because of recent advances in technology, the study of genes and induced ‘point’ mutations have led to the discovery and advancement of methods previously used in order to mutate genes. The development of Clusters of Regularly Interspaced Short Palindromic Repeats (CRISPRs) and CRISPR associated system 9 protein (Cas9) technology is a hugely significant leap forward as this is a tool that could potentially be used for the research into and hopefully the treatment of a range of medical conditions that are genetically related. Cystic fibrosis (Schwank, G. et al, 2013), haemophilia and sickle cell disease are an example of some of the conditions that have the

    Through recombinant DNA techniques, scientists have already experimented with bacteria and copied their cellular system that allows them to defend themselves from viruses in order to create a new restriction enzyme called Cas9, which then gets bound to an RNA guide strand. This new enzyme introduces new genetic material into the human genome as DNA replicates. This method will be useful for families members who carry harmful recessive alleles. Their babies could inherit the genetic disorder, but with recombinant DNA techniques, the harmful gene or genes could easily be replaced with a functional gene. Lauren Friedman, Senior editor for