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The Pioneering Experiments Performed By Hubel And Wiesel

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The pioneering experiments performed by Hubel and Wiesel in the mammalian visual cortex provided crucial insights into the experience-dependency of normal cortical development. Hubel and Wiesel capitalized on the finding of physiologically distinct neurons in the visual cortex that responded to varying degrees to monocular and binocular visual stimulation (ref), and by tangentially traversing through layer 4 of the V1 cortex while recording from individual neurons, they found that neurons responsive to the left or right eyes were separated into ocular dominance columns (ODCs) (Hubel and Wiesel 1962). The anatomical representation of these columns could be visualized by injecting a transneuronal radiolabel, H3-proline, into the eye of an animal to see projections of eye-specific LGN afferents to the cortex (Hubel Wiesel 1974). Using these techniques, they demonstrated that monocular deprivation corresponded to a substantial loss of cortical neurons stimulated by the deprived eye (ref), and resulted in an anatomical shrinkage of deprived eye columns with a concomitant enlargement of normal eye columns (ref). Further experiments suggested that experience-dependent maturation of ODCs relies on a competition-based mechanism whereby normal eye afferents become stabilized relative to deprived eye afferents (refs), and that there was a developmental critical period in which MD could influence ODCs that was maintained throughout adulthood (ref). Based on these observations as well as

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