The Influence Of Parkinson's Disease

Parkinson’s disease is a very well-known disease. It plagues about five million people worldwide, about a million of those cases are in the United States. A person does not lower their chances of getting Parkinson’s by living in a certain part of the world. It is not more, likely to happen in one location than, another. It has to do with age and genetics (“Demographics of parkinson’s,” 2014). It is a disease of the older generation, around about one percent of people over the age of 60 years old have Parkinson’s disease (Hauser, 2014). As one ages the likelihood of a person developing goes up. About four percent of people over the age of 80 years old develop Parkinson’s disease. The percentage of people who have Parkinson’s that are younger than 40 years old, is less than 10 percent. It is more

Many people around the world today suffer from Parkinson’s disease and other movement disorders. A movement disorder is a disorder impairing the speed, fluency, quality, and ease of movement. There are many types of movement disorders such as impaired fluency and speed of movement (dyskinesia), excessive movements (hyperkinesia), and slurred movements (hypokinesia). Some types of movement disorders are ataxia, a lack of coordination, Huntington's disease, multiple system atrophies, myoclonus, brief, rapid outbursts of movement, progressive supranuclear palsy, restless legs syndrome, reflex sympathetic dystrophy, tics, Tourette's syndrome, tremor, Wilson disease, dystonia, which causes involuntary body movement, and Parkinson's disease. Parkinson’s disease, Tourette’s syndrome, and tics are one of the most widely known of these disorders, known to impair people of movements and rob them of their lives.

Charcot examined a large group of patients within Salpetriere Hospital in Paris, he had developed a way to observe tremors in action and at rest. “He noted that the patients with action tremor had accompanying features of weakness, spasticity, and visual disturbance. In contrast, those with rest tremor differed in having rigidity, slowed movements, a typical hunched posture, and very soft spoken.” (Goetz 2011) Charcot early tremor studies helped to establish Parkinson’s Disease through his very high publicized findings that neurological entity could be confidently be diagnosed. In 1957 a Swedish scientist Arvid Carlsson found out that dopamine in the brain region that is important for movement control. He showed that the levels of dopamine can be reduced in animals to cause symptoms of Parkinson’s Disease and also by giving the animals levodopa (L-dopa) to reverse the symptoms of PD. PD is second most common neurodegenerative after Alzheimer’s Disease and the most common movement disorder. Over 60,000 people here in the United States are diagnosed every year but they say the numbers can be much higher with undiagnosed people out there but over one million people live with Parkinson daily.10 million people worldwide live with Parkinson’s Disease and April 11th is World Parkinson’s Day. On April 11th, 2017 marked 200 years since James Parkinson publicized his essay.

Parkinson’s disease (PD) is a type of progressive brain disorder in the human body. Brain activity becomes disrupted when nerve cells that produce dopamine start to break down. Dopamine is a neurotransmitter that is responsible for movement. When it’s at extremely low levels, one would experience symptoms such as slower movement, shakiness, problems with posture, and stiff muscles. Unfortunately, Parkinson’s is incurable, but there are different types of treatments to help slow down the progression of the disease.

There are some neurological impairments such as Parkinson’s disease especially in people that were in combat, lose control of the movement in their body part. Also, psychological impairments that include depression that may develop within three years of moderate or severe TBI or within 12 month when mild TBI.

There are many genetic disorders, but Parkinson’s disease is one of the worst. Parkinson’s disease affects people usually 50 and over. Because of rising life expectancies Parkinson’s is predicted to appear even more. So far there are treatments for Parkinson’s but no cure, and they don’t know when there’s going to be one. Even though Parkinson’s disease is not fatal it can reduce a person’s life span, as well as mess up the social experience and can also lead up to severe incapacity within 10-20 years.

Parkinson’s disease can be described as an issue within the nervous system that causes delayed and heavily impacted body motor skills. Sufferers face an intense loss of body movement; they face periods of unstoppable shaking, stiffened muscles, and delayed movement. Parkinson’s is commonly described as a physically impairing disease, but, in reality, it has the ability to have just as much impact on mental capabilities as it has on physical capabilities. Mainly, in the mental realm of impairment, Parkinson’s has a massive impact on emotional health. The disease and the manner in which the symptoms progressively worsen can be seriously detrimental to the well-being of a sufferer. Constantly dealing with the various symptoms and trying to cope

Parkinson’s disease is a slow progressive degenerative condition characterized by resting tremor, expressionless (mask-like) face, muscular rigidity, flexed posture, slow movements, and moderate to severe progressive dysarthria (Bhatnagar, 2002). Degenerative parkinsonian disorders can be inherited or sporadic, but are all distinguished by a loss in selective populations of vulnerable neurons. The common factor for all degenerative parkinsonian disorders is loss of dopaminergic neurons of the substantia nigra that project to the putamen (Dickson, 2012). It is most prevalent in over one percent of the elderly population and is the second most common neurodegenerative disease after Alzheimer’s disease (Benninger, 2013). However, Parkinson’s disease may also occur in younger adults and can affect both men and women (Medline).

Parkinson’s disease is one of the few diseases that have been around since ancient times. In the ancient Indian medical system of Ayurveda this disease was referred to as Kampavata. In AD 175 the physician, Galen of the western medical literature referred Parkinson’s disease as “shaking palsy”. It was not until 1817 that a detailed medical essay was published on the subject by London doctor, James Parkinson. The publication was titled “An Essay on the Shaking Palsy”. This officially established Parkinson’s disease as a medical condition. The essay was based on six cases he observed in his own practice and on walks around his neighborhood. The essay was to encourage people to study deeper into the disease. Over the years the study of Parkinson’s

Parkinson’s disease is a disease that affects the nervous system. Some common symptoms of Parkinson’s disease are tremors, slowed movement, impaired posture and balance, and speech changes. These phenotypes that are expressed in humans with Parkinson’s disease are also expressed in mice. Mice have a nervous system that is comparable to a human’s nervous system. In this experiment, mice will be exposed to radiation and the new phenotypes will be observed to determine the causes of Parkinson’s disease as well as the gene location for the mutation using forward genetic screening methods. If a mouse exhibits these symptoms stated above, then it is likely that they are a carrier of Parkinson’s disease, which will be passed onto the next generation.

Parkinson’s disease is a common form of Parkinsonism, affecting as many as one out of every hundred people aged 65 years and over. The disease prevalence increases with age, with

Parkinson’s Disease is a chronic neurological disease that primarily results in the interference with a person’s motor capabilities. James Parkinson; an influential physician described the disease as being a “shaking palsy” and was the first to identify the signs and symptoms of the disease, however this would later coin the name Parkinson’s1. Parkinson’s is notorious for being a progressive condition meaning that with age it worsens and the effects will gradually limit a person’s functional ability.

Parkinson’s disease is growing in the elderly population other than Alzheimer's. Parkinson’s is an incurable disease, in the journal article “Parkinson’s disease risk from ambient exposure to pesticides”, Parkinson’s is defined as “a common movement disorder associated with the degeneration of dopaminergic neurons of a substantia nigra” (Wang et al, p. 548, 2011). The national library of medicine indicated symptoms of Parkinson’s disease include “trembling of hands, arms, legs, jaw and face, stiffness of the arms, legs and trunk, slowness of movement, and poor balance and coordination (“National Library of Medicine,” 2014). Even though some may hear or even see a person with Parkinson’s disease (PD), there is a lack of knowledge about who is

According to a 2006 survey, five percent or 1.5 million Americans have Parkinson’s Disease. The number of people with

Parkinson’s disease has been known about since ancient times. In AD 175, the physician Galen described it as “shaking palsy” in Western medical literature. It wasn’t until 1817 that a London doctor, named James Parkinson, wrote a detailed medical essay on this disease. This essay established Parkinson’s disease as a recognized medical condition. He based the essay off of six cases he had observed previously and hoped that it would encourage others to study the disease. No such research was performed until finally, sixty years after Parkinson’s essay was published, a French neurologist named Jean Charcot studied the disease and was the first to truly recognize the importance of Parkinson’s work. As a result, he named the disease after him. Much has been learned about the disease since then; however, much of it still remains a mystery. Researchers have learned that the symptoms for this disease are progressive, degenerative, and tend to occur more in older individuals. It has been found that a dopamine deficiency of the brain is the root of the matter; although, why this initially occurs is less clear. The Parkinson’s Disease Foundation was created in 1957 to assist those who are suffering and promote and fund further research. Since the 1960’s research has only progressed more and more rapidly. Even though there still is no known cure, the symptoms can now be effectively controlled and reduced in severity. Moreover, many other foundations assisting the cause have been