After reading the study, the most obvious future study in my mind is adjusting the treatment period of the mice. In the future, the mice should be treated for a longer time period with the MSCs. I would like to know specifically if there were negative long-term effects for using this over a longer period of time for this purpose. In class, we learned that injecting stem cells can be dangerous in that although they have the ability to become multiple types of cells in the body, it is hard to control what type of cell they evolve into. With cells that are potentially unregulated in the body dividing, this has the potential, in my opinion, to cause problems if used for extended periods of time. Additionally, another risk of using stem cells …show more content…
Perhaps one group receiving a calorie restricted diet, while another a high fat and yet another high carb. Looking at the health risks that make psoriasis simulating treatments easier or harder to induce. This information would be interesting to study because of the work that could be done to look at preventative measures. If diet has a role on the reaction that the body has to the inducer, doctors and health care professorial could better advise individuals about the effects of lifestyle choices as well as to educate individuals about risk factors that could impact them.
A slight change to this idea would be to vary the activity level of the mice used and look at the effect that high or low activity has on the effectiveness of the treatment with MSCs. Looking at the effective because, in more fit individuals, the cells in the body are in a stressed state more often, and therefore may be more likely to have a healthier immune response. Looking at the effect of having more resilient cells in the body would be able to be part of a treatment plan therefore if this was seen to be a positive influence on the effect of MSCs in the body. This study would look at the measures that would be suggested by a doctor once psoriasis is deemed to be the cause of illness of an individual. Finding routes that make a medicine more effective would benefit individuals especially who are unable due to conflicting medicines or health purposes are
Psoriasis: This is a common, chronic and recurring skin disorder that changes and alters the life cycle of skin cells. It causes cells to accumulate quickly on the skin surface. The extra cells from the skin forms a thick, itchy, silvery scale and a red patch. It can appear at any part of the body such as the knee, scalp, elbow etc. it is treated with drugs applied to the skin, ingested and with ultraviolet radiation. This disease has affected about 1%-5% of the world population and it is more common to the light skinned people. Psoriasis may persist throughout a person’s life as it comes and goes but it is usually reduced during the summer period when the skin is exposed to ultraviolent radiation and flare ups are common during
This essay explores and reflects on the lived experiences of an elderly patient living with the long-term condition (LTC) of psoriasis. A case study is used to illustrate some of the key features of LTCs and the impact they can have on a patient’s physical, psychological and social state. It is also going to be looking at the effect some of the key features can have on a patients support network or family. In addition it will examine the nurses role in the management of LTCs and the health and social policies that may have an impact on the care received by patient with LTCs.
The pathophysiology of psoriasis is characterized by epidermal hyperproliferation, enhanced antigen presentation, T helper 1 cytokine production, T cell expansion, and angiogenesis. (El-Darouti and Abdel Hay, 2010 ).
Background: Plaque psoriasis is a painful autoimmune disease that affects up to 3% of the US population.1 Moderate-to-severe psoriasis can have significant psychological and physiological effects on a person’s health and although psoriasis can be controlled, it cannot be cured, so medications play an important role in reducing related comorbidities and improving patients’ quality of life.2
Scientists need to know that all the stem cells completely change into the tissue to avoid negative side effects, like tumors, when the cells are implanted in patients. Scientists also try to experimentally treat diseases with no cure with stem cells by implanting them into animal models, like mice (Freedman 13).
Terry is a 57 year old male who suffers from severe plaque psoriasis (L40.0), along with arthritis. His symptoms include dusky to deep erythema, very thick tenacious scale predominates on his scalp, face, arms, abdomen, back, genitalia and legs, involving more than 10% of his BSA. He has tried and failed various treatments including taclonex, cultivate, fluticasone, triamcinolone and halog, with little to no relief. He is not a candidate for PUVA or other light therapies due to location of psoriasis. Terry has been dealing with psoriasis for years and the location has caused him embarrassment and a decrease in self-esteem, not to mention affecting his quality of life. Enbrel is his best treatment option at this time. Without this treatment
“Psoriasis is a long-term (chronic) skin problem that causes skin cells to grow too quickly, resulting in thick, white silvery, or red patches of skin.” (WebMD, 2012) To uneducated individuals, they may look at a person with Psoriasis and think to stay away from them as it might be contagious. This disorder is not contagious, but it does affect a person with Psoriasis to go through social exclusion and discrimination. A mistaken trigger in the immune system is said to be the one of the causes of rapid production of skin cells in the body. Patients with Psoriasis produce new skin cells between 2-6 days. That is a little over four times less than the time they are normally produced, which is 21-28days. “Psoriasis affects approximately 3% of
Psoriasis is regarded as an autoimmune disease in which genetic and environmental factors have a significant role. The name of the disease is derived from Greek word „psora‟ which means „itch‟. Psoriasis is a non-contagious, dry, inflammatory and ugly skin disorder, which can involve entire system of person1. It is mostly inherited and mainly characterized by sharply marginated scaly, erythematous plaques that develop in a relatively symmetrical distribution. The most commonly affected sites are the scalp, tips of fingers and toes, palms, soles, umbilicus, gluteus, under the breasts and genitals, elbows, knees, shins and sacrum2. This disease is chronic in nature with a tendency to relapse. In this disease, the skin keeps scaling as flakes
It is considered moderate-to-severe if it involves >5% of body area or involves crucial body regions, which include hands, feet, face, and genitals.4, 8 Family history is prevalent in 1/3 of patients with psoriasis.6 Additionally, there are many environmental triggers of psoriasis, including smoking, stress, cold weather, alcohol abuse, and drugs such as beta blockers, lithium, NSAIDs, and tetracyclines.8 Though psoriasis is primarily known as a skin and joint condition, it can also increase the risk of non-melanoma skin cancer, lymphoma, and cardiovascular disease.6 Psoriasis also has implications in a patient’s social and mental
1. Dietary supplements can help ease psoriasis symptoms from within. Fish oil, milk thistle, vitamin D, and evening primrose oil have been reported to help a few sufferers. It’s imperative to just take supplements that don't meddle with other prior conditions or have harmful side effects. Fish oil applied specifically to the skin has additionally been known to work for some
Treatments include topical creams or ointments, phototherapy and systemic medications. These treatments help reduce inflammation, remove scales and smooth the skin. For patients who are suffering with Psoriasis, it’s important for him/her to talk to a doctor about their condition. Doctors will start with a mild treatment and then move on to stronger treatments if necessary. Lifestyle and home remedies will also help improve the appearance and feel of the damaged skin. These remedies include daily baths, use of moisturizer, exposing the skin to small amounts of sunlight and avoiding consumption of alcohol. Psoriasis is not curable but with the treatments and remedies listed above, a person can live a healthy and normal
There are many types of diseases of the Integumentary System, some worse than others, yet they still all affect the Integumentary System in some type of way. Psoriasis is a skin disease marked by red, itchy, scaly patches, and it is an immune-mediated, inflammatory condition which affects nearly 3 percent of the world’s population, is not contagious, and it affects both males and females, no matter what age or ethnicity they are. Psoriasis could be painful, their lesions could crack open and bleed, and itching could also occur, though sometimes it might not even be painful at all. In the research article “Patient Preferences for Treatment of Psoriasis with Biologicals: A Discrete Choice Experiment” by Christian Kromer, Marthe-Lida Schaarschmid,
Psoriasis is estimated to affect 2-4% of the population. The rate of occurrence varies according to age, ethnicity, gender and the region. A combination of genetic and environmental factors are thought to be responsible for these differences (Parisi et al., 2013).
Psoriasis is a dermatological condition that is chronic and progressive. It affects almost all surface of the body. It is associated with excessive growth of skin on the affected areas like the nails, palms, soles, elbows, knees, trunk, abdomen and back. There is no cure available as on date, but there are measures and medications that can help to decrease the vigorous symptoms which affect the quality of life which makes the patient feel negative and depressed. It is not contagious, many a times due to ignorance psoriasis patients are isolated for fear of getting infected by the family members. The dramatic representation of an uncontrolled psoriasis really affects the social life and employment prospects of the patient feeling the patient
Psoriasis was copied from the Greek word psora, which means “to itch” (Jean, 2011). Psoriasis is a chronic, long lasting autoimmune skin disease that disturbs the speed of the growth cycle in skin cells (Stress-Related Disorder Sourcebook, 2016). Normal, healthy skin cells replace dead skin cells every twenty-eight to thirty days (Langley, 2005). Skin is the largest organ in the body. It protects from the environment, regulates body temperature, helps coordinate immune system regulation, function of touch sensations, waterproof, and prevents toxin substances from entering the body (Langley,2010). Psoriasis effects greater than three percent