The Genetic Inheritance And Discovery Of Rheumatoid Arthritis

Rhematoid Arthritis – Is an autoimmune disease which can cause chronic inflammation of body`s organs, joints, and the surrounding tissue of the joints. It can

Rheumatoid Arthritis(RA) is the most common type of autoimmune arthritis. RA is a progressive and debilitating musculoskeletal disorder that affects the joints symmetrically, causing a range of systemic effects. What it causes is still not well known; nevertheless, findings of new research points towards a believe that it is triggered by a defective immune system, which causes the release of inflammatory chemicals. These chemicals cause damage to cartilage and bone, usually affecting the wrists, the joints of the hand, including the knuckles, the middle joints of the fingers and feet. While this condition can affect any joints, besides, important body organs such as the eyes and the lungs can also be affected by the inflammation that occurs as a result of this chronic condition. Only in America 1.3 million of people are affected by this ailment, and 75 % of them are mainly women. Its onset usually occurs between fourth and sixth decades; however, RA can occur at any age("Diseases And

In my rotation at Georgetown, I sought to explore the field of rheumatology at a tertiary level and in doing so, gained experience in common autoimmune conditions and some rare ones as well all which served to solidify my interest in the field. One of the most pleasant aspects of my duties at Georgetown was the opportunity to work with children. In taking pediatric rheumatology consults, I realized that as a rheumatologist I may be able to care for patients of all age groups, leading to an interesting and highly diversified

“Rheumatoid arthritis is a type of chronic arthritis that occurs in joints on both sides of the body, such as both hands, both wrists, or both knees. This symmetry helps distinguish rheumatoid arthritis from other types of arthritis”. If a joint is deemed as arthritic that means that there is inflammation within the joint. Inflammation within a joint can cause swelling, redness, warmth and pain within that joint. Rheumatoid arthritis primarily affects the joints, but may also affect the skin, eyes, lungs, heart, blood, or nerves. Rheumatoid arthritis can present itself in many different ways. For some, joint symptoms develop gradually over several years, while others may develop quickly. Some people are affected by rheumatoid arthritis for a short

Rheumatoid Arthritis has been subject of numerous studies and researches in the look for a better understanding of how it effects the individuals diagnosed with it. There is a higher incident of females diagnosed with RA than male as well as a relationship with genetic and environmental factors involved. Around one percent of the world population is affected by RA; therefore, diverse studies have been performed to understand how the lives of the diagnosed patients can be impacted by the disease. For example, how RA affects the mobility, safety and activities of daily living in general as well as the development of interventions to better approach RA. On

There are different types of arthritis such as gouty arthritis which causes a swelling usually in the big toe, psoriatic arthritis that often occurs along with psoriasis and reactive arthritis which usually involves the eyes, urethra and joints. Juvenile arthritis is an umbrella term used to describe any form of childhood arthritis or arthritis-related conditions which affects people under 16 years old. The most common form of childhood arthritis is juvenile chronic arthritis (JCA) which is also referred to as juvenile rheumatoid arthritis (JRA). Individuals who suffer from JRA experience stiffness and joint inflammation that result into swelling, warmth, soreness and redness of the joints. JRA, also

Juvenile Rheumatoid Arthritis (JRA) is a chronic and progressive autoimmune disorder of the joints. In JRA the joints become stiff, swollen, and inflamed causing pain and loss of movement. The cause is thought to be genetic and/or related to environmental factors which are still not understood. Because of its origin not being well understood, JRA is also called juvenile idiopathic arthritis. The body has abnormal immune responses wherein it attacks normal cells and tissues causing damage to the joints (McMahon Anne-Marie, 2011).

Juvenile idiopathic arthritis (JIA), previously known as juvenile rheumatoid arthritis (JRA), is an autoinflammatory disease that begins before the age of 16. (2) The cause behind JIA is currently unknown. Symptoms of JIA are a fever (a rash usually accompanying the fever as well), enlarged spleen, presence of arthritis, and also always a sign of systemic inflammation

Rheumatoid Arthritis or (RA) is an autoimmune disease that attacks the joints and connective tissue. The result is inflammation that produces permanent damage in the joints. Rheumatoid arthritis is a chronic syndrome that tends to be progressive and destructive as compared to Osteoarthritis or (OA), which is more of an age related disease caused by “wear and tear” of the joints. In contrast to (OA), rheumatoid arthritis is characterized by inflammation mostly of the joints, but is a general body disease.

     Juvenile Rheumatoid Arthritis (JRA), or sometimes called juvenile chronic arthritis, is a disease that affects children causing joint inflamation which makes the joints stiff and painful. This Disease affects about one in one thousand children ages sixteen and younger. Doctors have also found that the more joints affected the more serious the disease and symptoms are less likely to go into full remission.

"Rheumatoid joint inflammation is an interminable infection set apart by irritation of the joints, frequently influencing the hand joints and both sides of the body in the meantime" (Royal Australian College of General Practitioners, 2009).

Rheumatoid arthritis is a chronic syndrome that is characterized by inflammation of the peripheral joints, but it may also involve the lungs, heart, blood vessels, and eyes. The prevalence of this autoimmune disease is between 0.3% to 1.5% of the population in the United States (Feinberg, pp 815). It affects women two to three times more often than men, and the onset of RA is usually between 25 and 50 years of age, but it can occur at any age (Reed, pp 584). RA can be diagnosed by establishing the presence of persistent joint pain, swelling in a symmetric distribution, and prolonged morning stiffness. RA usually affects multiple joints, such as the hands, wrists, knees, elbows, feet, shoulders, hips, and small hand joints. RA is

Arthritis is without doubt one of the most usual motives of body joint affliction. There are several specific types of arthritis which might be induced

Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. While inflammation of the tissue around the joints and inflammatory arthritis are characteristic features of rheumatoid arthritis, the disease can also cause inflammation and injury in other organs in the

Arthritis occurs when the body incorrectly identifies its own tissue as foreign matter and attacks it. Arthritis includes a set of more than eighty autoimmune diseases. Arthritis attacks connective tissues and joints. It causes stiffness, pain, inflammation, and swelling of the joints. Some kinds are crippling, but rarely leads to death. There are many different