The Effects Of Resveratrol And Its Effect On The Risk Of Neurodegeneration, And Alzheimer 's Disease

One of the most prominent and perhaps most feared condition associated with aging is dementia. The family of disorders can cause individuals to lose their mind, reducing one from being a complex, thinking, feeling human being to being confused and vegetative, unable to recognize their loved ones. Serious dementia affects nearly 37 million people globally, but predictions of how those numbers will change over the next few decades are conflicting (textbook). Although we know dementia as to do with damage to nerve cells in the brain, there are ongoing studies looking at correlations between other health issues and these types of diseases.

FRIDAY, Sept. 11, 2015 (HealthDay News) -- High doses of resveratrol, a compound found in red wine and berries, may have some activity against Alzheimer's disease, a preliminary clinical trial suggests.

As aging is becoming a worldwide phenomenon, polyphenols have gained interest as potentially modifiable protective factors against neural diseases, such as dementia. The risk factors of cognitive function decline are not comprehensive, while the mechanisms may involve oxidative stress and inflammation. Epidemiological evidence shows that food contained flavonoid, which antioxidant and anti-inflammatory properties, is associated with a lower risk of neurodegenerative disorders and better cognitive evolution of the performance in the elderly(60). Although animal models are more properly used to investigate cellular and molecular mechanisms of the neuroprotective effects of Vaccinium berries, there

The main objective of the research was to examine the relationship between resveratrol, a substance that is extracted from plants and found in certain foods, and the delayed development of Alzheimer’s disease.

Alzheimer’s Disease has been one of the top leading causes of death in our country. It is understood that this disease is identified as an excess of the protein amyloid-ß within an increase of plaque (Seneff, Wainwright, and Mascitelli, 2010). Additionally, as the brain ages, it gets used to the inflammation and oxidative stress, so it is important to take the right amount of antioxidant micronutrients like vitamin C and vitamin E as well as anti-inflammatory macronutrients such as omega-3 polyunsaturated fatty acids to protect the brain from ageing (Whalley et. al, 2004). This is a devastating disease that affects most people over the age of fifty. Recently, there have been many studies done to figure out what causes this disease, if there is anything that can cure it, and how to prevent the disease. Seneff, Wainwright, and Mascitelli, believe Alzheimer’s develops with consuming too many carbohydrates, especially fructose and having a deficiency in cholesterol and dietary fats as well (2010). Whalley, Starr, and Deary have seen that poor diet, poverty, and failing health are links to developing Alzheimer’s Disease (2004). Furthermore, seeing increase in plasma homocysteine concentration increases risk of Dementia, which can result from an inadequate intake of vitamin B12/folate (Walley et. al, 2004). Additionally, Gray supports Walley’s findings and even believes having an adequate intake of vitamin B12/folate will have a positive effect on the overall health

Dementia is a syndrome which is progressive in nature, characterized by impairment of memory and loss of intellectual ability.1 Decreased level of Acetylcholine in the brain, neuro-inflammatory reaction, rise in the oxidative stress and hypercholesterolemia have been reported to play an important etiological role in the memory decline.2 Alzheimer’s Disease (AD) is the most common form of dementia which is a progressive and a neurodegenerative disease characterized by the presence of senile plaques rich in insoluble aggregates of β amyloid and neurofibrillary tangles in the brain. AD has been estimated to account for 50–60% of dementia cases in persons over 65 years of age worldwide.3 Alzheimer’s Disease International

Alzheimer disease (AD) is the most common cause of dementia in the elderly, accounting for 65–70% of all cases (Jellinger, Janetzky, Attems, & Kienzl, 2008). The other dementias are of the Parkinson 's group, the fronto-temporal group and the vascular group. The total worldwide yearly costs for the treatment and care of patients suffering from dementia are estimated to be around 250 billion US dollars. The lifetime risk for AD between the ages of 65 and 100 is 33% for men and 45% for women with an annual increase of 1–2% in the seventh decade to almost 60% in the 10th decade with doubling every 5 years (Jellinger et al., 2008). AD is incurable, and thus represents a major public health problem. AD represents a challenge to humanity due to its relatively recent discovery, progressive nature of the illness, and complex diagnosis.

Resveratrol is an antioxidant that is naturally found in grapes, peanuts, pomegranates, blueberries, pistachios and cranberries. Plants naturally produce it in order to fight off attack from harmful bacteria and microbes, to survive in times of drought or to compensate for times when the plant does not have adequate nutrients. Research suggests that one capsule a day may help in the fight against cancer, heart disease and Alzheimer’s disease. Other findings suggest that the nutrient helps to prevent insulin resistance in diabetics and keeps platelets in the blood from sticking together and forming clots. Vitrition Resveratrol is produced from only all-natural, healthy components to ensure you get the maximum

Most of the older persons in my family have developed dementia at their old age. “Attempting to avoid dementia development, some risk factors taken into account include ones that are unable to be modified: age with age-influencing early-life deleterious conditions, gender, and genetic influence. Additionally, several inborn physical attributes factor in such as lack of early education, environmental stress, and major unexpected circumstances that include accidents and trauma associated with increased risk for dementia. Physical activity has been suggested to weaken the pathophysiology of dementia through constant blood flow to the brain (sustained cerebral perfusion) due to the established relationship between hypertension and dementia. Some examples of physical activity include: dancing, undergoing either usual care or exercise for 60 minutes twice a week. ‘Physical activity’ refers to ‘usual care plus physical activity.’” Although some studies suggest that nutrition-wise antioxidants, fish oil, omega-3 fatty acid, and other supplements help delay the onset of dementia, there has been no absolute prevention from neither physical activity nor nutrition.”

Dementia is a disease that affects a vast number of Americans, and people worldwide. As people grow and live longer in today’s world the cases of clinical dementia are increasing. There are many causes of dementia, equally leading to different forms and symptoms of this disease. Most causes of dementia are known, and labeled in order to establish proper treatment. Alzheimer’s disease is the most common form of dementia, accounting for more than half of all people with dementia. The cause, and symptoms of Alzheimer’s disease are well known within the scientific community, but a cure is yet to be discovered. This show that there is still much improvement to be done within the scientific and medical

With the growing number of people becoming diagnosed, and experiencing symptoms of Alzheimer’s disease, we must begin to take precautions and somehow attempt to gain knowledge of how the disease can be better treated, and ultimately prevented.

Alzheimer 's disease which chronically leads to Senile Dementia, is a horrific change in homeostasis for human beings. The most obvious change in homeostasis from Alzheimer 's is loss of memory. Memory loss can vary from short term to long term. Alzheimer 's disease has been occurring in humans for a long time. This is a disease that affects different body systems, and interrupts homeostasis to a significant point. As Alzheimer 's disease is further investigated, there are more discoveries with how it is caused, what it affects, and how to reduce the risk of developing it. Alzheimer 's disease is a frightening disease that is represented in humans. There are many concerns with this disease that are worth finding out for the future victims

Alzheimer’s Disease (AD) is a progressive and neurodegenerative form of dementia that causes problems with memory, thinking, reasoning, judgement and decision-making, recognizing, as well as behavior, and is serious enough to interfere with daily life and activities, that eventually leads to profound physical as well as mental disabilities, resulting in the need for institutional care (Hoyer & Roodin, 2009). AD is most widespread in senior population aged 65 and over, which constitutes approximately 85-95% of the cases, in the rest of 5-15% of the times Alzheimer’s Disease can have an early-onset (before 60 years of age) (Hoyer & Roodin, 2009). According to Alzheimer’s Association, today Alzheimer’s Disease is at the forefront of biomedical research, as it is the sixth leading cause of death in the United States (alz.org). Researchers hope that better understanding of Alzheimer’s and related dementias can lead to discovering new and effective treatments. United States is not the only country that is facing this issue, this problem is global. According to the recent epidemiological studies, the worldwide prevalence of Alzheimer’s Disease will rise from 27 million people worldwide in 2006 to 66 million in 2030, and 115 million in 2050 (Werner, 2012). The main risk factor for developing AD is chronological age (Hoyer & Roodin, 2009). This means that by 2050, one in three persons over 80 years of age will most likely suffer from some sort of dementia, most likely from AD

Research has shown in the past that red wine may be good for the heart; however, current research shows that it may also prove beneficial in preventing certain tumors and even reducing the incidence of Alzheimer’s disease. The discovery comes as a result of the combined efforts of Alzheimer’s disease researchers at UCLA and Mt. Sinai School of Medicine.

There are associations described between dementia, mild cognitive impairment (MCI) and diet (1-4), also, there are nutrients with protective associations suggested by clinical research such as vitamin E and folates. Nevertheless, several foods like chocolate are left aside without accounting for the beneficial effects of its compounds, not only for dementia but also for other diseases (5). Similarly, chocolate is a widely consumed palatable food and easy to access, so it could have a convenient use as a part of nutritional therapy.