Abstract:
“Age-related macular degeneration (AMD) specifically affects the macular region of the central retina, where both ganglion cells and cones are present at very high densities.” (Penfold & Provis, 2005). In this paper, the origins and effects of macular degeneration, both Age-related (usually expressed in adults over 50) and Juvenile (occurring in the teens and early 20’s) are analyzed and discussed. I hate my life.
As the most complex organ in the human body and the only externally viewed organ connected directly to the brain, our eyes undergo numerous changes throughout the course of our lives. Within the eye, there are various structures working synchronously to ensure a maintenance of clear and functional vision. The purpose of this paper, is to explore a condition that affects a large percent of the human population. Disrupting our vision at its most central point, Macular Degeneration is a condition linked directly to the deterioration of photoreceptors in our retinas and thus our visual perception is reduced. Moving forward, we will explore the environmental and genetic aspects that affect and exacerbate this condition, attempt to answer the questions “is there is a way to prevent the condition from manifesting, and is there a way for it to be cured?”, and discuss the implications this condition has on the orientation and mobility field. Anatomy of the eye
The normally functioning human eye is a complex system of checks and balances, and necessary
Retinitis Pigmentosa (RP) is one of such currently untreatable causes of blindness. RP, along with Age Related Macular Degeneration (AMD) are amongst the more frequent causes of blindness in the developed world (Greenwald 2009), while RP itself is the leading cause of inherited blindness (Palanker 2004).
Age-related macular degeneration (AMD) is the leading cause of blindness for people 60 years of age and older in the developed world. Vision loss is caused by the destruction of the cone photoreceptors, located in the macula, that are responsible for color/central vision. The underlying cause of AMD is the loss of the monolayer of pigmented epithelial cells located just below the photoreceptors, known as the retinal pigmentum epithelium (RPE). The main role of the RPE is to maintain the function of the photoreceptor layer by secreting nutrients, absorbing stray light, and recycling debris used during the visual cycle. As a person ages the efficiency of the RPE layer is diminished causing a build up of toxic by-products. These toxic build-ups, known as drusens, result in the separation and death of the photoreceptor and RPE layers. AMD is speculated to result from as many as 20 different genetic mutations and as a result there is no known cure for the disease (CITE), but recent advances in stem cell therapy is a hopeful step in the right direction.
Macular Degeneration is a disease of the eye that gradually causes loss of a person’s central vision. Approximately 1.75 million Americans suffer from vision loss associated with the disease (All About Vision 1). The leading cause of blindness in people over the age of 60, Macular Degeneration, exists in two types (National Eye Institute 1). Both the wet and dry versions of the disease have similarities in risk factors, but differ in symptoms and treatments.
To understand how macular degeneration affects the eye, we must first know how the eye itself functions and why it is important to have the macula intact. A heathy eye is made of different layer that helps people to see colors, movement and to see images plainly. The macula is part of the retina, the retina is
The effect of omega-3 long-chain polyunsaturated fatty acid intake (LCPUFA) on neovascular age-related macular degeneration (NV AMD) and central geographic atrophy (CGA) over a 12 year intake was studied through a prospective cohort study. The cohort was from the Age-Related Eye Disease Study (AREDS), which is a large phase 3 clinical trial that has tested nutrient and vitamin supplement formulations as prevention methods for AMD. Categories of AMD and risk of progression were determined by the size and extent of drusen and abnormalities of the retinal pigment epithelium (RPE) in each eye, the evaluation of stereoscopic photographs, and visual acuity (SanGiovanni et al., 2009). AREDS supported that individuals with the highest intake of
The first disease I’m going to mention is Glaucoma, according to Web MD last updated in 2015, Glaucoma is a condition that causes damage to your eye's optic nerve and gets worse over time. It's often associated with a buildup of pressure inside the eye. Glaucoma tends to be inherited and may not show up until later in life.
The research topic I will be introducing is Age-Related Macular Degeneration. This has been classified as a degenerative disorder that distresses the macula in one’s eye. AMD is unfortunately a common illness that individuals over 65 suffer from and that is a central cause vision loss. AMD doesn’t have a set disease pathway, in some individuals it advances slowly so that loss of vision does not arise for a long time. The disease can also advance much quicker and may lead to lack of vision in either or both eyes. The disease begins a blurry area near the center of one’s vision which grows larger and larger possibly causing a blank space in the eye (Boyd, 2013). Research is being done on AMD because it is a prevalent illness and has extreme consequences.
Retinitis pigmentosa is a group of inheritable diseases that is characterized by gradual deterioration of the photoreceptors in the retina. The photoreceptor cells in the retina, rod cells, are light sensitive cells that are able to sense low levels of light. The frequency of retinitis pigmentosa is one in four thousand births (Deng et al., 2015; Fahim et al., 2012; Haddad et al., 2016; Shu et al., 2012) People affected by retinitis pigmentosa will typically exhibit symptoms of night-blindness first, and this will precede a loss in the patient’s visual acuity field that starts from the outer edge and gradually moves inward resulting in a much smaller visual field and loss of peripheral vision, also known as tunnel vision (Haddad et al., 2016).
I have participated in the program Lunch Is Served, held at the First United Methodist Church in Sioux Falls. The goal of this program is to gather volunteers to pack lunches to aid the working poor, ultimately fixing the major hunger problem in Sioux Falls. I have attended this volunteer opportunity five times, and plan to volunteer again in the future. Essentially, those who participate pack as many brown paper bag lunches as possible in a streamlined fashion. Included in the bag is usually various nutritious snacks and a wrapped sandwich that will be given to those in need. My experiences there was very humbling, due to the fact that it made me realize the impact one person can have on the community. All it takes is a half hour of
The development of the human body is an exquisite process that involves numerous complicated processes for even the smallest of body parts, including the eyes. The eyes are an extraordinarily complex organ capable of gathering information through refracted light and sending it the brain to assemble a picture. They provide the ability to see and follow a moving object and the capability to tell an approximate distance of an object. When light passes through the cornea and iris pupil, at the anterior portion of the eye, it is focused by the lens onto the retina at the back of the eye. Photoreceptor cells, which are present in the retina, detect the light and send information to interneurons which begin to sort out the information. This information is then sent to ganglion cells which transmits the final information to the brain (Sowden 199). Because the eyes have such complicated and exquisite processes, the likelihood of developmental errors occurring are possible. A large number of these developmental errors lead to congenital defects and abnormalities that effect the individual’s eye sight. Some of these defects and abnormalities can cause serious diseases and syndromes that effect more than just the eyes, but also neurological processes, facial dimorphisms, growth failure, tracheal development, and genitalia anomalies.
CART Major Assessment Eyes are the medium where one’s visions conjoin with reality. When I think of the image of eyes, the first word that comes to my mind is vision. What our eyes see and what we envision have many commonalities, yet they are different. The acknowledgement of this truth first occurred to me in the third grade when I received my first pair of glasses. The world begun to lose its clarity however, I had not yet noticed.
As vital organ of vision, the eye, allows us to learn more about the world around us more than any other organ or senses. Sight, the physical sensory experience and vision, the metaphysical concept of how our brain interprets images both work harmoniously and play a huge role in our everyday lives. However, almost a billion people are either blind or visually impaired simply due to not having a pair of glasses. Being able to lead people in the direction of good vision is what developed my interests.
Basically what my research is stating is that there is a major genetic component that contributes to this disease. There are three general types of hereditary Macular Degeneration. The first is called early onset. This is when you get it when you are four years of age up to seven. In this type both parents and their children can be affected. This means it is dominantly inherited. Most of the time this is called Best Disease or Viteliform Macular Degeneration.
For the past thirteen years of my life, I have grown up in one of the smaller towns of the Rio Grande Valley. I have had fierce competition and a sub-par education. However, do not let this deter you from accepting me.
Life can throw a lot of gifts and obstacle right in your face. Good or bad, the best way to cope with a gift or obstacle is to tuck them tight in your pocket and learn from them. Everyone has their own story, but everyone can relate to each other somewhere in the journey of life. A few of the small things that have affected my life in a big way are high school football, instagram, and sports injuries. High school football, probably the biggest impact on my life, has taught me morals, lessons, and discipline that I feel I will carry and use throughout my life. Football is so much more that just a game. It offers a sense of different type of knowledge one can use. Another big impact that has thrown me for some downs but however more ups