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The Canid Genology : Analysis Of The Evolution Of Canids

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Canidae have more than 70 homologous regions in there detected chromosome probes, indicating canids karyotypes are among the most rearranged in mammals. The majority of conserved segments characteristic for carnivores have been broken into several pieces in the canine genome, indicating the canid genome is very advanced. The domestic dog is a well mapped species and is the ideal candidate for comparative genomic studies. Graphodatsky et al. describes the mapping of the domestic dogs chromosomes-specific probes to those of fennec foxes, dholes and gray foxes and the mapping of red fox chromosome-specific probes on corsac fox chromosomes. They will also discuss the evolution of the structure of the canid genome and reconstruct the Canid …show more content…

For the phylogenomic reconstruction, dog chromosomes were used to define the 10 canids genome-wide homologies as well as the homologies of two ursid species that acted as out groups. Ambiguous characters were coded with ‘?’ which include the 18a/38 and 18b/38 characters in gray fox and four Vulpes karyotypes. The canid species were ran through a maximum parsimony analysis, global statistics were calculated along with a 1000-replicate bootstrap tree. Chromosome changes were highlighted using the outgroup and mapped onto a tree. Implication of Results: Hybridization of dog chromosomal probes to the G-banded metaphases of dhole, fennec fox, and gray fox was successful. The dog and dhole have identical karyotypes as shown by the one to one mapping of the 39 dog probes and the 39 chromosome of dhole. Fennec foxes displayed a similar one to one mapping but chromosome 1,13,18, and 19 probes hybridized to two regions within the fennec fox chromosomes. In gray fox, chromosome 1,2,13,18,19 also hybridized to two distinct segments. For the hybridization of red fox chromosome onto corsac chromosomes, the 28 red fox probes hybridized to two segments each, suggesting the red fox probe contains sequences in the form of telomeric heterochromatic blocks. Even though red and corsac foxes belong to the same genus, they do not share a single autosome meaning their karyotypes could have evolved through fusions and

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