Epinephrine Induced Takotsubo Cardiomyopathy Background: Takotsubo cardiomyopathy also called as Stress-induced transient cardiomyopathy, apical ballooning syndrome, and broken heart syndrome was first reported in 1991 [1 in Japan, and accounts for 1.2% of acute coronary syndromes (ACS) that present with elevated cardiac biomarkers [1,2,3. The condition is often associated with acute medical illnesses, catastrophic life events, and intense physical or emotional stress [2, 3. Although the pathogenesis of stress-induced cardiomyopathy is not fully understood, the hypothesis includes catecholamine excess [16, coronary vasospasm, micro vascular dysfunction and dynamic mid cavity or left ventricular outflow tract obstruction. Postmenopausal women appear to be at a higher risk for developing the disease as about 80% of Takotsubo cardiomyopathy occurs in postmenopausal women [3]. …show more content…
The cardiomyopathy can be classified into a left ventricular (LV) apical ballooning variant (classic Takotsubo cardiomyopathy—most common), an inverted or reverse Takotsubo variant (basal akinesis with hyper dynamic apex), or a mid-ventricular Takotsubo variant [1. In this paper, we are presenting a case of epinephrine induced classic Takotsubo cardiomyopathy, which provides an evidence to support the role of epinephrine in the pathogenesis of this
Dr. Arantza Manzanal explains how takotsubo was initially described “as a syndrome of reversible LV dysfunction with wall-motion abnormalities that involve the apical and midventricular segments” (57). Dr. Paolo Angelini rationalizes that “only during the last 2 decades have Japanese authors specifically categorized transient takotsubo cardiomyopathy (TTC) as an entity in itself. Before that time, TTC was often called “acute myocardial infarction with normal coronary arteries” (312). We will
Arteries: carry blood away from heart; oxygenated except for pulmonary circulation and umbilical vessels of fetus
Hypertrophic Cardiomyopathy was discovered by Donald Teare, a pathologist, about five decades ago (1958). Over the last 50
An dysrhythmia of the heart is an irregular heartbeat rhythm. Ventricular tachycardia is an dysrhythmia in which the lower chambers of the heart, the ventricles, beat unusually fast.
Someone could feel okay and happy with them self if they killed somebody because of an eye. The narrator in Edgar Allen poes "The Tell-Tale Heart" kills his own roommate who is a elderly old man because his roommates eye intimidate him. He loves the man dearly but he just can't stand his eye. The man did no wrong to him. He killed his roommate and might be trying to plead insanity. The narrator should get charged with murder and she get sent to jail for killing the old man.
Cardiomyopathies can be caused by genetic disorders/defects, viral illness, some endocrine conditions, autoimmune diseases, and excessive use of alcohol and drugs. Pharmacology treatment of diagnosed LVSD is predominately the same, although it is recognised
With attention to her heart issues, I checked her capillary refill on both fingers and toes for perfusion, her pulse (62 bpm) and her blood pressure (120/58). Additionally, when she was getting up I had her sit for a minute before standing to decrease the likelihood of orthostatic hypotension.
During inspection of the heart assessment observe abnormal finding. Inspect the jugular vein and the carotid artery. Note pallor or cyanotic skin color, temperature, turgor, texture, and clubbing of finger. Observe for swelling, edema and ulceration. Clubbing is a sign of chronic hypoxia caused by a lengthy cardiovascular or respiratory. Poor cardiac output and tissue perfusion is noted by cyanosis and pallor. For dark-skinned, inspect his mucous membranes for pallor. Decreases or absent of pulse with cool, pale, and shiny skin, and hair loss to the area, and the patient may have pain in the legs and feet may indicate arterial insufficiency. Ulcerations typically occur in the area around the toes, and the foot usually turns deep red when dependent
Apical hypertrophic cardiomyopathy is a disease that mainly affects the apex of the heart and does not cause any obstruction. [1] These abnormalities in the heart muscle can cause a wide variety of symptoms. As the heart becomes stiff it increases the pressure in the left ventricle which can push blood back into the lungs, causing shortness of breath in exercise. Chest pain can occur as there is not enough oxygen available to the cardiac muscle due to insufficient blood supply. Palpitations and lightheadedness, along with other conditions can occur as a result of HCM. In addition to these discomforting symptoms, the patient may develop an arrhythmias that often goes unnoticed. An arrhythmia takes place as the electrical conduction of the heart is disturbed by the abnormal scattering of myocytes. The two most common arrhythmias are atrial fibrillation causing palpitations, and ventricular tachycardia that can be life threatening causing sudden death. Both conditions can be controlled with medication. [4]
“[...] 1 in every 100,000 children in the U.S. under the age of 18 is diagnosed with cardiomyopathy” (“Understand Pediatric” 1). This condition affects many children throughout the world. Some cases of cardiomyopathy are fatal, some allow the child to live with restrictions. Cardiomyopathy is the leading cause of death and heart transplants in children (“Understand Pediatric” 1). There are many different ways to help diagnose the numerous forms of this disorder, treatments to help stop other problems from occurring, and therapies to help the restrictions some may live with. Various medical fields have been looking into and studying what the leading causes could be for this disorder ("Progress to date" 1). There are many symptoms a child can show for a doctor to see in order for them
Due to great progress in genetic testing during the last decade, there is an increasing awareness of congenital heart diseases that give a higher risk of sudden cardiac death (SCD). A good example of such heart disease is the congenital Long QT Syndrome (LQTS). This disorder is a leading cause of SCD in the non-adult population.1 Ion channels responsible for the ventricular repolarization are mutated, causing a prolongation of the QT-interval on ECG.2 This aberrant repolarization of the heart gives a risk of the occurrence of ventricular arrhythmias, called torsades de pointes. These arrhythmias are mainly precipitated by emotional or physical stress2 and cause symptoms such as syncope or cardiac arrest.
The effects of stress and heart disease is explained in a study Chida and Steptoe (2009), in which investigators looked at populations of people in healthy known areas, and assessed in total twenty five different studies. Anger and hostility has a positive relationship with coronary heart disease and was greater in men compared to women. Their findings also showed that individuals who had cardiac arrest and were resuscitated, twenty five percent admitted to feeling extremely stressed with work and family instances just twenty four hours before they had cardiac arrest. Daily activities that provoked moderate, acute stress demonstrated lower levels of blood supply to the hearts muscle. Deanfield et al. (1984)
Congenital heart diseases (CHDs) are the most prevalent of all birth defects and the leading cause of death in the first year of life, (1) with an annual prevalence ranging from six to twelve affected infants per 1,000 live births. (2)
In December of 1992, my paternal grandfather suffered a heart attack. He had been hauling several 50 lb. sacks of corn up into the deer feeder on his property by himself. He got into his truck, turned the ignition, put it into drive and before he could take his foot off the brake, he was dead. He was 68 years old. I was thirteen and that seemed so old. I remember that prior to the event there were many conversations within my family about the condition of my grandfather’s heart and cardiovascular system and how he needed to make lifestyle changes. I remember him taking nitroglycerine pills. I remember him coming to Dallas to go to an appointment so that they could perform tests with names like “stress EKG.” I
It is the time of progress. The time of supercomputers, space shuttles, and many other wonders of technology. We have walked on the moon. We do our shopping at home via Internet navigation.