Hemophilia is an inherited bleeding disorder that is passed from mother to son. This affliction is passed in such a way due to the fact that the gene that is responsible for hemophilia is carried on the X chromosome that the child receives from his mother. For someone to be afflicted by hemophilia means that their blood has a difficult time clotting. There people do not bleed any faster than the average person, they simply cannot stop bleeding once they start bleeding. As of this current moment, there are no known cures for hemophilia, but there are many treatments that are highly effective in helping to treat many of the issues associated with the bleeding disorder. (citation)
The discovery of hemophilia is something that is not credited to one single person. The discovery happened throughout the course of history with the findings of many doctors and researchers combined. There is evidence that hemophilia was first recognized as a bleeding disorder 1,500 years ago in the Babylonian Talmud. The Talmud is a collection of the findings of great Jewish scholars. While the scholars were able become aware of how this bleeding disorder was inherited and only afflicted the boys, they were not entirely sure of the fact that it was passed from the mother.
While the discovery of hemophilia is not credited to one single person, the revelation that there were two separate types of hemophilia was found by Alfredo Pavlosky, a doctor who resided in Argentina in 1944. Pavlosky realized
Hemophilia is an X-linked recessive disease in which blood lacks blood-clotting proteins. Females have two X chromosomes, indicating that they are generally carriers and transmit the gene to their sons. People with mild hemophilia bleed after surgery, injury, or trauma. Severe hemophilia produces spontaneous internal bleeding in joints and muscles. Fortunately, medicines and lifestyle changes offers hemophiliacs fairly normal lives. Through learning about hemophilia, I became interested in genetic diseases and finding a cure for those
Hemophilia is the oldest known hereditary bleeding disorder. There are two types of hemophilia, A and B (Christmas Disease). Low levels or complete absence of a blood protein essential for clotting causes both. Patients with hemophilia A lack the blood clotting protein, factor VIII, and those with hemophilia B lack factor IX. A person with severe hemophilia has less than 1% of the normal amount of a clotting factor - either Factor VIII (8) or Factor IX (9). People without hemophilia have between 50-150% of the normal level of factor VIII or IX. There are about 20,000 hemophilia patients in the United States. Each year, about 400 babies are born with this disorder. Approximately 85% have hemophilia A and the remainder has hemophilia B.
Hemophilia is the name of a group of hereditary blood disorders that doesn’t allow the blood to clot normally (Frey 2009). More specifically hemophilia A, also known as factor VIII, is caused by a missing clotting protein coagulation factor VIII. It is often times referred to as the “Royal Disease” because of how it ran rampant through the royal families of England, Spain , Germany, and other European countries during the 19th and 20th century. Hemophilia A is inherited in X-linked recessive pattern. In males (who have only one X chromosome), one copy of the affected gene is enough to cause the condition. In females (who have two X chromosomes), a mutation on both of the genes would have to be present to cause the disorder. Because it is very unlikely that a female would have both altered copies on both of the genes females generally don’t get hemophilia. Since fathers can only pass on the Y chromosomes to their sons they can’t pass X-linked traits along (Hemophilia 2015). Hemophilia is linked to the mutation of the F8, on the X chromosome, as seen in Figure 1. Mutations in the F8 gene can cause faulty versions of the coagulation protein, therefore this protein cannot participate in the clotting process (Gersten 2014).
Hey do you know what hemophilia is? Well it's a bleeding disorder, when you bleed too much when having an injury making you have too much blood loss. There are treatments that can help you if you have Hemophilia ,but sadly we have no cure for it yet. When you have Hemophilia you have to stay away from things that can hurt you like when you are reading a book you have to be careful because you don't want a paper cut.The treatments that can help you when you have replacement therapy, replacement therapy is a treatment aimed at making up a deficit of a substance normally present in the body.
Hemophilia also known as the royal disease originated in England in the 19th and 20th century, It is a sex-linked disease that is carried in the X chromosome and, therefore; has a much higher frequency in males. This genetic disorder prevents blood from clotting causing the afflicted individual to bleed out. When someone has hemophilia their blood has complications clotting thus clotting factors are either decreased in quantity, absent, or improperly formed. Even one inactive clotting factor can cause an individual affected with the disease to lose great amounts of blood. (J. Wilson, 592)
If the person had a mild case of Hemophilia A, they can be injected with the hormone desmopressin, which gives the body more clotting factors to stop the bleeding. A person with a severe case of Hemophilia A or B may have to be injected with a donation of human blood to prevent the bleeding from continuing. Hemophilia C can be treated with a factor that is only found in Europe, however, plasma infusions are used to stop bleeding in the United States. If treatments fail to proceed in positive effects there are ongoing treatments to provide extra help. Physical therapy, vaccinations, and antifibrinolytics are treatments that can reduce hemophilia symptoms. Maintaining a healthy diet, exercising regularly, and maintaining healthy dental hygiene can help avoid excessive bleeding. If a family member has this disorder it is a good idea to see a counselor and to let people know in case of an emergency. Hemophilia is a blood disorder that doesn't effect the way a human lives if they choose to treat it correctly.
Hemophilia is a bleeding disorder where the blood doesn’t clot normally. Some symptoms of hemophilia are unexplained bleeding from cuts or injuries, large deep bruises, unusual bleeding after vaccination, pain, swelling in your joints, nosebleeds without a known cause, and blood in your urine. These symptoms vary depending on the level of clotting factors. Hemophilia are inherited in an X-linked recessive pattern. The genes that are associated with these conditions are located on the X chromosome which is one of the two sex chromosomes. It's more likely males will get this disease because males only have one X chromosome but females have two X chromosomes and for them to carry hemophilia they must get it on both chromosomes.
Occasionally a baby is born with this disorder and no family history of it. When this happens, it could be caused by a hidden gene, which is when several generations of female carry it, and it has not affected any male members of the family or a spontaneous mutation. With each pregnancy, a woman who is a carrier has a 25% possibility of having a son born with hemophilia. Since the father's X chromosome is what determines if the unborn child will be a girl, all of the daughters born of a man with hemophilia will be carriers. None of his sons, which is determined by the father through his Y chromosome, will have hemophilia. Individuals who suffer from mild hemophilia may choose to use a non-blood product known as Desmopressin acetate (DDAVP) to help treat the small bleeds and/or scrapes. For deep cuts or internal bleeding, the treatment called DDAVP may not be enough and therefore, may need a much more complex treatment. The clotting factor must be replenished so the affected person can form a clot to stop the bleeding. Plasma is one of the ‘human blood products’ than is used for factor replacement. Another factor replacement option is using the recombinant factor, which is produced in a laboratory.
Hemophilia is an inherited bleeding disorder that needs a lifelong treatment. Hemophilia could be A or “classic hemophilia” and hemophilia B or “Christmas disease”. Individuals with hemophilia A have factor VIII deficiency, and lack of deficiency IX results in hemophilia B. Hemophilia A is X-chromosome recessive mutation disorder affects females and males and affects 1in 4 males, while hemophilia B or deficiency in factor IX are X-chromosome linked abnormal bleeding that affects approximately 1 in 30000 males globally. Population affected with hemophilia A or B suffers joint bleeding that can be spontaneous, and overtime leads to hemophilic arthroplasty. Also, there may be swollen, joint pain and limited mobility
Hemophilia describes a group of sever congenital coagulation factor deficiencies. It is a lifelong genetic disorder with a prevalence of 1:10,000 birth and that of the most severe form of the disease to be approximately 6% per 1,00,000 Population (1). Depending on the activity of coagulant factor VIII or IX in blood, hemophilia may be labeled as severe (<1% of normal), moderate (1–4%) or mild (5–25%) (2) . hemophilia is characterized by recurrent haemarthroses inside the less muscular padding joints as knees, elbows and ankles joints (3).
It all started when Queen Victoria of England took the throne. She passed the hemophilia gene down to the next generation of her children and grandchildren
Hemophilia is a disease in which blood clotting is severely reduced making any small injury a much bigger problem because it cannot clot by itself. The symptoms associated with this disease have to do with blood and how it clots or in this case does not. This disease is in effect whether the bleeding is internal or on the surface of the skin. Depending on the severity of the disease an affected person may bleed a little bit longer or much longer than someone who does not have hemophilia. This all depends on the amount of FVIII in the person's plasma.
Hemophilia A was a fatal disorder. However, its treatment progressed rapidly around the middle of the last century when patients were infused with plasma or processed plasma products to replace Factor VIII. Around the mid 1980’s, the development of alternate Factor VIII sources for replacement therapy was discovered including monoclonal antibody purified Factor VIII and recombinant Factor VIII, both of which are used in replacement therapies.
Hemophilia is a group of hereditary genetic disorders that affects the body’s ability to cause blood clotting which stops bleeding after a blood vessel is broken. According to Zerwekh, Miller, & Cliburn (2012) hemophilia is a rare condition with only about one instance in every 1000 births for hemophilia type A and one in every 50000 births for hemophilia type B. In total only around 18000 people are hemophilic in the United States of America. Every year in the U.S, around 400 babies are born with the disorder ("Home | Hemophilia | NCBDDD
According to the Gale Encyclopedia of Nursing and Allied Health, hemophilia also spelled haemophilia, is a genetic disorder of the mechanism of blood clotting that is usually inherited (Fallon 1276). The symptoms of this disease can range from mild to severe which makes prognosis very difficult to determine. Sylvia Mader says, “Hemophilia is called the bleeder’s disease because the affected person’s blood either does not clot or clots very slowly” (489). Hemophilia is a rare genetic disease that affects 1 in 5,000 male births while about 400 babies with hemophilia are born each year (“CDC”).