Science Of Pleasure

Addiction, it is all around us, affecting people from all walks of life, it is not limited to certain social classes or lifestyles. It is found in every ethnic group, regardless of gender or age. It affects our neighbors, our friends, and our family either directly or indirectly. Although substances such as alcohol and illegal drugs are two of the most common addictions we hear about, there is a wide range of substances and even activities such as gambling and shopping. There is some debate whether addiction is a brain disease or a choice.

Addictive drugs cause dopamine neurons to release dopamine, the pleasure hormone. The narcotics disable the neurons that would usually keep the dopamine neurons in check; becoming over stimulated. Endorphins are produced and released within the brain, creating a high and reinforcing the individual’s positive associations with the activity. Hence “the rush” (Molintas, 2006)

This research paper will evaluate the biological aspects of addictive substance or behavior and how it affects the brain and organs. Biological aspects include dopamine levels that are replaced in the brain due to the reward system being overtaken and the absorption rate of the drug once it is ingested will be discussed. The biological aspects are extensive and permanent if the individual does not get the help they need. Furthermore the clinical issues of addictive substance or behavior will be discussed along with medical treatments and ethical issues. This includes treatments such as counseling

Brain chemistry can affect different addicts more then others. Drugs and alcohol are more of the main addictions that brain chemistry affects. Once taking these addictive substances your internal natural drug dopamine is lowers causing you to seek more external addictive substances. This causes craving and makes it a lot harder for the addict to stop. In Olds and Milner’s later experiments, they allowed the rats to press a particular lever to arouse themselves, to the effect that they would press it as much as seven-hundred times per hour. This region soon came to be known as the "pleasure center". Using drugs and alcohol stimulates the pleasure center in the brain that makes your brain think, “feels good- want more“. This can make it increasingly harder for an addict to stop using, until they hit a point called “rock bottom”. This is where choice comes back into play.

According to the biological perspective, drug use may start off as casual, but through continued use, it produces changes in the brain that influences the onset and maintenance of drug addiction. (Horvath et al., 2013). Drugs have their most prominent effects on the function of neurotransmitters. Almost all major drugs of abuse activate the reward system and cause a flood in the levels of dopamine which is a neurotransmitter that is involved in pleasure. As a result, not only do people learn to associate drug use with pleasure, but the brain also starts to reduce its own natural dopamine production in adjustment to the levels of dopamine produced by the drugs. This is called tolerance, and the consequences of tolerance are highly influential

As results of scientific research, we know that addiction is a disease that affects both the brain and behavior. A disease is an interruption, cessation, or disorder of a body system, or organ structure, or function; according to Stedman’s Medical Dictionary. (Sheff ,2013) cites, the disease od addiction has an etiologic agent, identified by a group of signs and symptoms or consistent anatomic alterations. There are significant changes in the brain. The American Society of Addiction Medicine (ASAM) states that addiction is a primary, chronic disease of brain reward motivation, memory and related circuitry. Dysfunction in these circuits leads to characteristics biological, psychological, social and spiritual manifestations. This is reflected in an individual pathology pursuing reward and /or relief by substance use and other behaviors. (Addiction is characterized by inability to consistently abstain, impairment of behavioral control, craving, diminished recognition of significant problems with one’s behaviors and interpersonal relationships and dysfunctional emotional responses. Like other chronic diseases, addiction often involves cycles of relapse, and remission. Without treatment or engagement in recovery activities, addiction is progressive and can result in disability or premature death. (ASAM Adopted as Policy, February

Addiction can be separated into three categories: mind (neurological), body (physical), and spirit (psychological). Within in this breakdown addiction can possibly be explained and properly understood.

Addiction starts in the frontal cortex of the brain where an individual’s hobbies, preferences, tastes in art or music, sense of humor and overall personality lie. Also, “certain areas in the frontal cortex are responsible for making decisions

To understand addiction further, it is important to look at how drugs have neurological effects in a human body. Drugs can be ingested in various ways; while some are taken orally, some are smoked (cannabis) while others are injected directly into the blood stream (Heroin). Once in the body, they mainly affect the reward pathway in the brain, known as the dopaminergic pathway, which in turn gives pleasure. Even though all drugs affect the reward and motivation pathways in the brain, their speed depends on the way the drug has been consumed. Over constant use of drugs, the cognitive functions are impaired as the effects become more prominent in learning, memory

Addiction happens in the area of the brain called the limbic system located in a portion of the brain outside the cerebral ventricles where it sends the chemical transmitter dopamine to the limbic system allowing the beginning stages of addiction to happen. Drug addiction has been conceptualized as a disorder that moves from impulsivity to compulsivity in a collapsed cycle of addiction comprised of three stages: preoccupation/anticipation, binge intoxication, and withdrawal/negative affect (Koob & Simon, 2009).

Imagine laying on the floor in your own pool of sweat—miserable, your mind bouncing off the walls while the cloud of your darkest thoughts looms over you. Teeth chattering anxiously, waiting to receive the next second, minute, hour of painless bliss. This—this is the life of an addict; does this horror appear to be a choice or more like a disease haunting the mind of the user? Despite the fact a choice was needed to initiate the result, addiction itself is a debilitating disease NOT a choice due to initial influences and anatomical changes to the brain.

The complexity of the human brain creates mystery when determining the influence of neurophysiological factors and their role in the process of addiction. There is a proposed relationship between drug addiction and the mesolimbic dopamine system, with the mesolimbic pathway from the ventral tegmental area to the nucleus accumbens considered the ‘reward centre’ of the human brain (Alcohol Rehab, 2011). A release of dopamine is necessary for ‘reward’ which is hypothesised to initiate the addiction cycle by providing positive reinforcement for drug self-administration (Feltenstein & See, 2009). Methamphetamine triggers the release of dopamine from synaptic vesicles which flood the synaptic cleft activating feelings of euphoria, well-being

Addiction has long been questioned whether it is a disease or a choice. Although this is mostly an opinion, this has larger impacts on things such as rulings in court cases and how health insurance may cover an individual struggling with addiction. I personally view addiction as a consequence of a series of poor decisions. There are many factors that lead me to believe addiction is a choice. This essay will cover what addiction is, scientific proof that addiction is not a disease, and lastly my personal opinion.

“The overstimulation of this reward system, which normally responds to natural behaviors linked to survival (eating, spending time with loved ones, etc.), produces euphoric effects in response to psychoactive drugs. This reaction sets in motion a reinforcing pattern that “teaches” people to repeat the rewarding behavior of abusing drugs ”(“Understanding Drug Abuse). Using addictive drugs floods the limbic brain with dopamine, taking it up to as much as five or ten times the normal level. A person with elevated dopamine levels now has a brain that begins to associate the substance with an outside neurochemical reward (“Your Brain on Drugs”). As a person continues to abuse drugs, the brain adapts to the overwhelming surges in dopamine by producing less dopamine or by reducing the number of dopamine receptors in the reward circuit. The result is a lessening of dopamine’s impact on the reward circuit, which reduces the abuser’s ability to enjoy the drugs, as well as the events in life that previously brought pleasure. The decrease in normal dopamine levels encourages the addict to keep abusing drugs in an attempt to bring the dopamine function back to normal, except now larger amounts of the drug are required to achieve the same dopamine high, an effect known as tolerance (“Understanding Drug Abuse ). That is what leads to the state of addiction, which leaves the person in a cycle of craving, using, withdrawal, and relapse.

At this point, drug use does not raise dopamine levels or produce a “high”; instead, the user keeps taking the drug to stave off painful withdrawal symptoms.