Reaction Paper On Hydrazones

Dictionary of organic compounds, 6th edition, Chapman and Hall, London, Volume 3(& Volume 6), 1996 Maria Lindsay and Sean P. Hickey, Organic chemistry lab 2 manual, department of Chemistry University of New Orleans

1. Girolmi, G.S.; Rauchfuss, T.B.; Angelici, R.J. Synthesis and Technique in Inorganic Chemistry: A Laboratory Manual. University Science Books, 1999.

T. Kolusheva, A. Marinova Journal of the University of Chemical Technology and Metallurgy, 42, 1, 2007, 93-96

To overcome this issue, many Azone-like compounds have been synthesized (55). Modification in the structure of Azone includes change in:

Calc. (%) for [Pd(C17H15ON)Cl]2 (675.94): C, 60.42; H, 4.47; N, 5.23; Pd, 15.74. Found: C, 61.10; H, 4.13; N, 5.53; Pd, 17.74. The experimental %Pd is obtained by TG curves.

However, some of these methods have notable difficulties such as harsh reaction conditions, long reaction times, difficult work-up, low yields of the products, and use of toxic and costly reagents, catalysts or media. Also, some of the starting mate-rials have to be prepared and purified first, hence these methods are time-consuming. The develop-ment of simple and efficient methods for the syn-thesis of 1,4-dihydropyridines are therefore desirable. 1,4-Dihydropyridines are an important class of heterocycles, since many 1,4-dihydropyridine-containing natural and synthetic products exhibit attractive pharmacological profiles, including anti-inflammatory,2 antitubercular,3 anticonvulsant,4 HIV protease inhibitory,5 analgesic,6 antithrombi-otic,7

fused bi- or tricyclic pyridazine containing scaffolds are key structural features of many biologically active compounds with diverse pharmacological applications. Based on the various advantages of pyridazines in drug design including modulation of the physico-chemical properties, improving ADME and toxicity profile as well as easy and diverse synthetic methods of access, makes them an invaluable tool for designing and synthesizing pyridazine based compounds as future drugs.

This analysis reveals that there are three π*→ π* interactions in unit 1 of both the molecules and two π*→ π* interactions in unit 2 with large stabilization energy. In unit 1 of p-IAd, the interactions such as π*(C1-C6) → π*(C2-C3), π*(C4-C5) → π*(C1-C6) and π*(C4-C5) → π*(C2-C3) arises with respective energy 1414.34, 2186.98 and 849.97 kJmol−1 . Likewise, the interactions π*(C1-C2) → π*(C5-C6), π*(C3-C4) → π*(C1-C2) and π*(C3-C4) → π*(C5-C6) in unit 1 of p-BAd attaining respective energy 1454.23, 2280.19 and 892.39 kJmol−1 The interaction π*→ π* with high stabilization energy 1306.13 kJmol−1 and 841.32 kJmol−1 is for the interaction π*(C15-C16) → π*(C19-C20), π*(C17-C18) → π*(C¬19-C20) occur within unit 2 of the p-IAd aromatic ring . Also,

Hydrazones and their derivatives constitute a versatile class of compounds in organic chemistry. These compounds have interesting biological properties, such as anti-inflammatory, analgesic, anticonvulsant, antituberculous, antitumor, anti-HIV and antimicrobial activity. Hydrazones are important compounds for drug design, as possible ligands for metal complexes, organocatalysis and also for the syntheses of heterocyclic compounds. The ease of preparation, increased hydrolytic stability relative to imines, and tendency toward crystallinity are all desirable characteristics of hydrazones. Due to these positive traits, hydrazones have been under study for a long time, but much of their basic chemistry remains unexplored. N-Acylhydrazones (NAHs),

Moscher, Karl F. “Molecular Modeling.” Encyclopedia of Chemistry. Revised Edition. Science Online, online.infobase.com/HRC/Search/Details/8?articleId=299674&q=Models%20of%20Molecular%20Compounds. Accessed 3 May

The purpose of experiment 9 is to use stimulation to observed the shape of molecules. This stimulation follows the valence shell electron pair repulsion theory to show the basic shapes of molecules and its effects on polarity. The shapes of molecules are represented by molecular and electron geometry. The electronic shape is determined by the number of electron domains, which include lone pairs and bond pairs. An example from the stimulation is H2O, which has 2 bonding pair and 2 lone pair. Therefore, it has four electron domain and is considered to have a tetrahedral electronic shape. However, the molecular geometry is not tetrahedral because molecular geometry only counts the bond pair as electron domain. Hence, the molecular

General Chemistry I: 1411 – 61500 Monday & Wednesday 6:00 – 8:50 P.M. Professor Shelia Fox Mountain View College December 2nd, 2015

4. Library and Archive Catalogue. "Metallic Bonds." ChemTeacher. N.p., 2 Nov. 2010. Web. 3 Feb. 2016. http://chemteacher.chemeddl.org/services/chemteacher/index.php?option=com_content&view=article&id=36

Keywords: A. Nano structures, A. Magnetic materials, B. Chemical synthesis, C. X-ray diffraction, D. Magnetic properties.

The nature of the particles and the type of form that is responsible for the linkages determine the structure of the network and the property of the gel 26 .