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Psychedelic Drugs

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Psychedelic drugs have been used by people around the globe for the last few decades. They’re known for their abilities to alter perception and invoke behavioral alterations in people who consume the drugs, such as psilocybin (magic mushrooms), DMT, and Lysergic acid diethylamide(LSD). In 1958 (Moore, Hatada, Dominos) it was found that when consumed by humans, N-N-Dimethyltryptamine (DMT), causes visuals that make up of colorful, luminous, rapid changing visual illusions and hallucinations. Ingestion of a psychedelic drugs such as DMT influences the cortex, optic lobes, and thalamus, as well as effecting sleep. A possible explanation for visual hallucination while under the influence of Dimethyltryptamine was presented by a research conducted in 1979. In mammals, such as cats, N-N-Dimethlytrptamine was studied with respect to the visual system. It was found that DMT caused a deceased amplitude response evoked by the stimulation of the optic chiasm. The depression of electrically evoked potentials in the visual system are DMT dose-dependent. The inhibition of the induced potential was recorded at the lateral geniculate nucleus and at the visual cortex. …show more content…

It is a structurally similar to serotonin and melatonin. There is considerable evidence suggesting that Dimethyltryptamine acts as a non-selective serotonin agonist (5HT-1A and 5HT-2A). It was seen in the prefrontal cortex of mice that serotonergic hallucinogens interrupt cortical synchrony in the low frequency range. Mice that were administered DMT experience a reduced serotonin release in the prefrontal cortex via the 5HT 1A receptor. Another revelation observed was the reduction of low frequency cortical oscillations in somatosensory, auditory, and visual in wildtype mice. DMT fully prevented the effect of knockout serotonin 2A receptors by the 5HT 1A receptor agonist. (Riga, Bortolozzi, Campa, Artigas, & Celada.

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