DISCUSSION
Androgenetic alopecia (AGA) is a common worldwide problem. It is manifested by progressive hair loss in scalp hair, and has specific patterns of hair loss in women versus men, but central scalp is most severely affected (Varothai and Bergfeld , 2014).
In Androgenetic alopecia there is conversion of circulating androgens into dihydrotestosterone within the hair follicle (Sadighha and Zahed, 2009).
The bioactivity of Lipids in the skin in health and disease is unexplored. Prostaglandin D2 has been identified to be elevated in the bald scalp of men with AGA and it decreases hair lengthening (Nieves and Garza, 2014).
Prostaglandin D2 is a major cyclooxygenase product generated by activated mast cells. Other possible cellular
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Prostaglandin D2 receptors are in the outer root sheath of the hair follicle. Early reports are consistent with receptor's localization withen among other areas to the upper and lower outer root sheath region as well as the dermal papilla. Therefore the location of receptors is appropriate to imaging a functional importance for hair follicle activity (Colombe et al., 2008).
Prostaglandin D2 might explain sebaceous hyperplasia in AGA. Although controversial, PGD2 and its non-enzymatic break down product 15-deoxy-delta12, 14-prostaglandin J2 are published as ligands for PPARgamma. PPARgamma is a known master transcription factor for adipose development and also supports sebaceous gland function. Therefore it is tempting to consider that the high levels of PGD2 might explain the dramatic increase in sebaceous gland size in AGA (Trivedi et al., 2006).
The aim of this study was to evaluate the serum level of PGD2 in androgenetic alopecia patients, in order to evaluate its possible role in this hair
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Also, (Oztuk et al.,2014) reported that there was a strong correlation between BMI and severity of AGA.
There has been no study on the correlation between BMI and PGD2 level. The study of Garza et al.,(2012) didn't correlate BMI with local production of PGD2. Prostaglandin D2 locally produced inside bald scalp should be correlated with BMI to better elucidate its role in the pathogenesis of androgenetic alopecia.
In our study, there was a negative strong correlation between the serum level of PGD2 and the duration of androgenetic alopecia.
This could be explained by the results of (Springer et al.,2003) who reported that AGA increased with prolonged duration of the disease due to androgen exposure shortens hair follicle anagen phase as men with increased androgen levels and women with increased 5 reductase enzyme. Affected hair become shorter, finer, less pigmented and progresses with each successive cycle related to higher dihydrotestosterone (DHT)
Hyperandrogenism often presents itself in the physical form with acne, hirsutism (male-patterned hair growth), and alopecia. While insulin resistance is typically present in a patient with a higher BMI, 70% of women with PCOS have this condition, putting them at a higher risk of developing Type 2 diabetes (Goodarzi et al., 2011). Other metabolic complications can occur with PCOS, including hypertension and dyslipidemia (Madnani, 2013). The hormonal secretions of the body’s endocrine glands are affected by the hormonal secretions of the ovaries and vice versa via feedback mechanisms. The disruption of normal hormone secretions, particularly hypersecretion of luteinizing hormone (LH), can reduce the chance of conception and increase the risk of miscarriage (Balen,
Involutional Alopecia is a natural condition that comes with aged. The hair follicles gradually go into thinning while the remaining hairs become shorter, fewer, and brittle. In this condition, the thickness as well as the volume decreases. Involutional alopecia causes normal hairs to reach the telogen phase very quickly, and then leave the telogen phase (through shedding) too quickly also. It is linked to a variety of factors, such as genetics, diet, or
Alopecia Areata: A disease which causes the body to form antibodies against hair follicles. It can result from such factors as stress, genetics and the immune system. Alopecia Areata causes sudden, smooth, circular patches of hair loss.
According to PubMed Health, Polycystic Ovary Syndrome (PCOS) is a condition in which women possess abnormally high level of male hormones. The high hormone levels lead to risks of irregular or absent menstrual cycles, insulin resistance, ovarian cysts, issues related to the circulatory system, obesity, heart disease, diabetes and etc. Symptoms differ between each woman therefore, despite research data collected showing that PCOS affects 5-10% of women between the age of 18-44, there are many women who live their lives unaware that they have PCOS. The most common symptoms include: absences of ovulation, high levels of androgen present, and abnormal hair growth. The cause of PCOS is still unknown as more research is much-needed to better understand the disorder.
For this article there were no research questions, but the authors wanted to focus on the pathogenesis, diagnosis and treatment of PCOS. They found that polycystic ovary syndrome (PCOS) is common in women, with a10% prevalence in women of reproductive age. Polycystic ovary syndrome is defined as ovarian dysfunction with polycystic ovaries. It also includes androgen excess which is shown by testosterone levels being elevated. Increased levels of testosterone can be seen through excess body hair. Obesity is seen in many women with PCOS, this can lead to insulin resistance and Type II Diabetes. Genetics has an impact on polycystic ovary syndrome with 20-40% of people with PCOS having first-degree relatives with the syndrome.
Children The Information Hair Loss - Adult Style.National Alopecia Areata Foundation, alopecia is a common disease is usually diagnosed in childhood reports. Children's Alopecia Project, according to cheap lace wigs to make hair loss is caused by the rapidly growing white blood cells attacking the hair follicles. Does not attack the root of the follicle is the supply of new cells, which means that the growth potential of the
DHT does not affect only males, as many women will also experience hair loss caused by DHT production. DHT is an androgen, and females produce this in smaller amounts
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive aged women, with a prevalence of 16.6-18% according to the 2003 Rotterdam criteria (1-3). Though PCOS is extremely common, up to 70% of women with the syndrome are undiagnosed (3). The PCOS diagnosis is one of ovarian dysfunction and hyperandrogenism, and as such has important implications for reproductive health (see Table 1; NIH, 2012). However, in addition to these reproductive criteria – which tend to manifest as hirsutism, infertility, and pregnancy complications – PCOS is marked by
Males can pass the PCOS gene down through there families just as much as a female can pass it on. There are some males that are more hairy than other males; these males have been shown to carry the PCOS gene. Studies also show that males that carry the PCOS gene are more likely to have a lowered sperm count. It is also mentioned that the males of PCOS are insulin resistant.
Androgenic alopecia, the most common type of alopecia, is caused by shortening anagen phase and telogen phase prolongation.10-11 Another cause of Androgenic alopecia is about androgen hormone. The androgen hormone involves in the hair production process due to it can bind with receptor in dermal papillae cells of follicles and alter the paracrine production in hair cells.24 Androgen effects on hair are different depending on the body site. For scalp area, androgen causes the transformation of terminal follicles to become vellus hair that is tiny and pale hair leads to the baldness appearance.
Boys and Girls – Pubic hair development ((Bickley, & Szilagyi, 2013., Family Practice Notebook, 2012)
Hirsutism is excess terminal hair that commonly appears in a male pattern in women. Terminal hair refers to the stiff, pigmented hairs normally seen in men on the face, chest, abdomen and back, which are not normal for women. The cause of hirsutism can be either an increased number of androgen's in women, an oversensitivity of hair follicles to natural levels of androgen's in women, adrenal hyperplasia, thyroid dysfunction, Cushing syndrome, androgen-secreting tumors and certain medications. The most common cause of hirsutism is polycystic ovary syndrome, accounting for every three out of four cases. In those not related to medication use, evaluation is focused on endocrinopathies and neoplasms.
Have you ever thought about losing hair when you are 60 years old? Besides looking awful, does becoming bald mean something else to you? Believe it or not, it actually determines how likely you are going to suffer from heart disease. The first research study on the correlation between baldness and heart disease was conducted almost 60 years ago, in 1954. The shocking research results aroused much attention of the science community. As baldness had been found to be very common from the middle aged onward, the general public became very aware of the conclusion of the positive relationship. Many subsequent research studies have been conducted afterwards, in order to gain a more thorough insight into the notion, and most importantly, to disclose
They evaluate the scene, develop, secure, and package evidence for evaluation, prepare detailed reports on the observations and activities at the scene, and testify in court regarding the findings and processing methods used at the scene. Employment in the CSI field should continue to grow for years. The expanding population will demand for more law enforcement personnel, which includes CSI professionals. CSI salaries vary depending on what region you’re in, the type of employer you have, the government level (local, state, federal), and specializations in the field. They spend time at crime scenes because they have to gather evidence and details. They also spend time in the law enforcement agency’s lab, examining evidence under a microscope. They are usually under pressure to get results quickly. They will need good eyes for detail, and be able to work under high stress.
Hair loss is a condition affecting both men and women. There are several causes of hair loss. In men, hereditary factors play an important role in hair loss. Such a condition is termed as male pattern baldness or androgenetic alopecia. This is linked to elevated levels of DHT in the scalp. This is characterized by hair loss in the temples and top regions of head and presence of thinning hairs elsewhere.