Xylitol is an attractive natural sweetener polyol that is commonly used in a variety of pharmaceutical formulations. The most prominent disadvantage of xylitol in pharmaceuticals is its unsuitability for tableting by direct compression. The objective of this study was to develop stable xylitol particles with modified physical properties, improved compactibility and enhanced biopharmaceutical performance without altering its polymorphic form. Xylitol was crystallized using antisolvent crystallization technique in the presence of various hydrophilic polymer additives, i.e., polyethylene glycol (PEG), polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) at a range of concentrations. Crystallized xylitol without additive and xylitol crystallized in the presence of PVP and PVA demonstrated significant improvement in hardness of directly compressed tablets; however, such improvement was not observed for xylitol crystallized in the presence of PEG. Crystallized xylitols produced enhanced dissolution profiles of indomethacin in comparison to parent xylitol. The influence of additive concentration on tablet hardness was dependent on the type of additive, whereas an increased concentration of all additives brought an improvement in the dissolution behaviour of indomethacin. The highest total desirability was achieved from xylitol crystallized in the presence of the highest concentration of PVP (1.2% w/v).The crystallization process did not influence the stable polymorphic form or
The product was then suspended in 2 ml of water with a stir rod in a 50 ml Erlenmeyer flask and heated to boiling. Water was added in one milliliter increments until all the product was dissolved (18 ml added total). The saturated solution was allowed to slowly cool, and gradual white crystal formation was observed. Recrystallized product was collected once more by suction filtration with the Hirsch funnel once crystallization ceased. Collected product dried on a watch glass for a week, weighed 0.14 g (1.2 mmol), and the melting point was 139°-141°
Aspirin, Caffeine and Salicylamide were extracted from an over-the-counter pain reliever (BC Powder). These components were separated by manipulating their solubilities by adjusting the acidity and basicity of the solution. By doing this, the three components were forced into conjugate acid (or base) forms, causing selective solubility in either an aqueous or organic solvent. These layers were then separated by use of a separation funnel. Once separated, the components extracted were characterized by measuring the melting point and performing a TLC analysis. Also, the recovered aspirin from the first part of the experiment was recrystallized and compared to that of the
Experimental Method: Polyethylene glycol 3350(PEG) was placed in water in order to measure the amount of time it took for the PEG to dissolve. The amount of both PEG and water were the same for each trial, the only changing factor was the temperature of the water. Timing started the moment PEG was placed into water, and the timer was stopped once PEG was dissolved.
The mixture was transferred to an ice bath to crystallize the product, after which the product was collected by vacuum filtration on a Hirsch funnel, washing the flask with small aliquots of cold xylene and pouring the solution over the crystals, allowing the vacuum to thoroughly dry the product. Additional drying was achieved by transferring the product to filter paper and pressing the crystals to remove any excess moisture. The product was then weighed and a melting point determined. A comparative TLC was run in Hexanes:Ethyl Acetate solvent against maleic anhydride to verify the purity of the
High Noon is a classic movie that is considered one of the greatest movies of all time. On the other hand, The Most Dangerous Game, written by Richard Connell, is just another short story. The main character of High Noon is Will Kane, and Sanger Rainsford is of the other. Both of these people are fighting for survival, but they cannot get help in one way or another because they are alone figuratively and physically; the setting is also similar yet nothing alike. Although the setting for High Noon and The Most Dangerous Game are similar, other aspects of the stories are quite disparate.
Acetic Anhydride and p-Aminophenol were heated in a vial attached to an air condenser to synthesize crude acetaminophen, resulting in 0.097 grams (47.48% yield). The crude acetaminophen was then recrystallized in a solvent of water and methanol over heat resulting in 0.082 grams (39.61% yield) of pure acetaminophen. Melting points of both crude and pure acetaminophen were taken, and found to be 165.9 - 170.9°C and 168.2 - 171.5°C, respectively. The literature melting point of acetaminophen is 169.5 – 171.0°C, indicating that our final product was pure.
Which brand of painkilling medicine dissolves the fastest and does flavor, coating, and color of the pill affect the dissolution time? If several different pain neutralizing pills are placed in stomach acid and timed in order to find out which pill dissolves first, then the most effective pill will be the first to dissolve. In order to test this, eight different types of pain neutralizing medicine were put into simulated stomach acid and timed. Normal strength, liquid gel capsules, and children's flavored pills were all tested. In order to accurately simulate stomach acid, vinegar, which has the same pH levels of stomach acid, was heated to thirty seven degrees Celsius and stirred constantly and evenly. The pills tested were Advil, Children's
General Info- Coke, a soft drink created around 1886, is quickly booming into one of the most recognizable brands in the world. It has spawned dozens of different flavors and merchandise. However, it is a highly acidic substance, with a whopping 2.52 on the pH scale. The lower the pH number, the higher the acidity. This is because of the acids that make up the drink, such as phosphoric acid, added to give a tart flavor and thickness (or viscosity) to the drink.
Introduction Crystallization is a technique that has been utilized as a part of the purification of substances. As often as possible, when a solid substance (single compound) is dissolved in a solvent, it dissolves. After adding a greater amount of the solid, a point in the long run is come to past which no further solid dissolves, and the solution is said to be saturated with the solid compound. The concentration of the saturated solution is influenced by the temperature, by and large a higher temperature bringing about a higher concentration. These events can be utilized as a methods for affecting separation and purification.
The drug PCP(Phencyclidine) is a white crystalline powder that is soluble in both water and alcohol. The drug comes in a variety of forms: tablets, capsules, and colored powders. With use of PCP, there are short-term, long-term, and psychological effects.
The Progressive Reform Movement ideas were to make the educational institutions effective agencies where there was respect for diversity, as well as a place to gain educational understanding on their quest of being citizens that believe in service for others (Weiler, 2004). Furthermore, there was a belief that within the classroom setting, there would be a democratic relationship that would focus on the needs of the students, rather than the institution (Progressive Education – Philosophical Foundations, Pedagogical Progressivism, Administrative Progressivism, Life-Adjustment Progressivism, n.d.).
When you first step on that brightly lit field, immediately you are put on sensory overload. The mixture of the lights and the dull screams from the crowd resonate in the back of your mind and do not completely leave you until after the game is long finished. Normally, you are standing on the outside of the field in the student section, instead of out on the turf. This year that is not the case. You are a privileged upperclassman now, and with that title comes the opportunity to play in the much-anticipated Powder Puff game.
A crystal is made up of the same materials that a regular glass is made of, such as silica, soda, and lime, but the addition of lead oxide is what gives crystals their shine. A bead has to have 24% lead oxide added to qualify as leaded crystal. Contrary to the popular belief, crystals have been around for a long time. Ancient Egypt, Rome, and other groups have all used crystals for various purposes. It was used in medicine, magic and rituals, as offerings and currency, as well as important gifts and items of beauty. Ancient civilizations were able to use crystals because natural crystals are dug from the ground where earth’s temperature and pressure causes them to form. However, one can make a crystal at home. It is
Controlled crystal formation is important to acquire a certain texture in crystalline candy. Crystalline candies are smooth, creamy, and easily chewed with a definite structure of small crystals that resemble tiny snowflakes. Examples of crystalline candies are fondant, fudge, and penuche. When a concentration of sugar is higher than 121 degrees Celsius, it is an amorphous or non-crystalline candy, these are candies formed from a sugar solution that does not crystallize such as peanut brittle, and caramel. The purpose of this lab is to understand how temperature influences the texture, and firmness of
As a young boy, Naveen lived in a small, cozy home with his parents. Him and his father loved to cook together and they made the best gumbo in the city. Their dream was to open a restaurant together one day, so that night when Naveen’s mother and father were putting him to bed, he made a wish on an evening star and hoped that their dream would come true. As Naveen was growing up, he kept wishing and hoping to have his own restaurant but he knew deep down that wishing was not always enough. He worked really hard to try and make his dream come true but, with this came no time for fun or for love.