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Powder: Crystallized Xylitol

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Xylitol is an attractive natural sweetener polyol that is commonly used in a variety of pharmaceutical formulations. The most prominent disadvantage of xylitol in pharmaceuticals is its unsuitability for tableting by direct compression. The objective of this study was to develop stable xylitol particles with modified physical properties, improved compactibility and enhanced biopharmaceutical performance without altering its polymorphic form. Xylitol was crystallized using antisolvent crystallization technique in the presence of various hydrophilic polymer additives, i.e., polyethylene glycol (PEG), polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) at a range of concentrations. Crystallized xylitol without additive and xylitol crystallized in the presence of PVP and PVA demonstrated significant improvement in hardness of directly compressed tablets; however, such improvement was not observed for xylitol crystallized in the presence of PEG. Crystallized xylitols produced enhanced dissolution profiles of indomethacin in comparison to parent xylitol. The influence of additive concentration on tablet hardness was dependent on the type of additive, whereas an increased concentration of all additives brought an improvement in the dissolution behaviour of indomethacin. The highest total desirability was achieved from xylitol crystallized in the presence of the highest concentration of PVP (1.2% w/v).The crystallization process did not influence the stable polymorphic form or

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