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Postoperative Analgesine Essay

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Introduction:

Significant postoperative pain following major surgical procedures for breast cancer is a common and well-known complication which may lead to a lot of negative consequences as more hospital costs with extended hospital stay, and the increased incidence of chronic post-mastectomy pain (2). Procedural interventions involving regional blocks are found to be more effective than pharmacologic pain relief methods(3). Pecs1 and 2 can provide effective postoperative analgesia for such procedures (4). They are field blocks that aim to deposit the local anesthetic between the pectoralis major and minor muscles and between pectoralis minor and serratus anterior respectively to block the different peripheral nerves supplying the …show more content…

The hypothesis was that adding ketamine or dexmedetomidine to bupivacaine would result in improved the analgesic efficacy of ultrasound guided PECS block.

Methods:
This prospective randomized double blind clinical trial was conducted in accordance with the Declaration of Helsinki and FDA Regulations. After institutional approval of this study by the ethical committee of Saudi German Hospital Saudi Arabia (#REC 11/01/2017), the study was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12617000851369).
90 Patients ASA physical status 1-3 aged between 18 and 60 years scheduled for modified radical mastectomy were included in this study and all the patients signed an informed consent for the procedure. Exclusion criteria was settled to include patients with history of advanced cardiac disease, sepsis, patients with prior surgery in areas above or below the clavicle or in the axillary region, those with opioid dependence or alcohol or drug abuse, those with coagulopathy, and those with psychiatric illness that prevent them from proper perception and assessment of pain.

In the pre-induction room the patients were taught how to assess their own pain score using the numerical rating scale (NRS) (0–10; 0 = no pain, 10 = worst imaginable pain) and how to use the device for a patient-controlled analgesia (PCA) (CADD–Legacy® PCA ambulatory infusion pump,

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