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Post-Traumatic Stress Disorder Case Study

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Post-Traumatic Stress Disorder (PTSD) is a debilitating neuropsychiatric condition affecting approximately 25 million Americans (U.S. Department of Veteran Affairs, 2015). PTSD is characterized by anxiety, hyperarousal, hypervigilance, and depressive symptoms that develop in individuals following a life-threatening or exceptionally stressful event (American Psychiatric Association, 2013). Standard PTSD treatments primarily include cognitive behavior therapy along with medication targeted at symptom reduction, such as antidepressants, antipsychotics and anxiolytics (Baker et al., 2009; Jeffreys et al., 2012; Farach et al., 2012). However, a meta-analysis of data pooled from 92 studies has revealed that as many as half of all patients do not …show more content…

In studies of trauma-exposed soldiers, a high natural production of NPY was found to be associated with positive coping mechanisms in trauma-exposed soldiers, while decreased levels of NPY were observed in patients who were depressed and suffering from the effects of PTSD (Yehuda et al., 2006, Wu et al., 2003). Together, these data have shown the NPY-ergic system to be a promising target for intervention and as a pharmacological agent for PTSD treatment. These findings led to numerous rodent model studies introducing NPY as a therapeutic through intranasal infusion, allowing the peptide to effectively and rapidly bypass the blood brain barrier (Serova et al., 2013). When introduced via intranasal passage, NPY was demonstrated across multiple studies to attenuate the development of numerous behavioral impairments, such as anxiety, depression, and hyperarousal, associated with PTSD (Sabban et al., 2014, Sah et al., 2007, Laukova et al., 2014). Furthermore, research determined that intranasal NPY treatment prevented the rise of glucocorticoid receptors in the hippocampus (Sabban et al., 2013). This demonstrates that NPY attenuates the development of PTSD-like symptoms at a biochemical level, as elevated numbers of glucocorticoid receptors have been shown to result in a hyperactivated response to stress in the hippocampus (Sabban et al., 2013). Despite the great promise NPY holds for future treatment

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