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Porrcine Small Intestinal Submucosa Essay

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Porcine Small Intestinal Submucosa Porcine small intestinal submucosa (SIS) is an acellular biomaterial derived from the small intestines of pigs. SIS is a great product that is used because it is predominantly made of collagen, which is the main component of extracellular matrix. Extracellular matrix is a collection of extracellular molecules secreted by cells that provide the structural and biochemical support of surrounding cells. Therefore, the SIS is a scaffold that can be implanted into the body, to reinforce surgical fixes and allows cells the ability to grow throughout the scaffold. SIS is a product on the market that is sold by Cook Biotech. Cook Biotech creates many products using the SIS, such as hernia devices, dura grafts, …show more content…

One example of erosion that has occurred that has created multiple complications is a pelvic floor implant. When the mesh pelvic floor implant was implanted many patients had issues with the device eventually eroding through their uterus or bladder. The issue of eroding occurred for many companies that sold a mesh pelvic floor implants thus the issue became a major problem. Since, so many people were having issues with the pelvic floor implants it became a major lawsuits area and every company on the market that sold pelvic floor implants was suited. Even though the SIS pelvic floor implant did not cause issue Cook Biotech will not sell the product in the United States because the lawsuits have made it a huge liability. SIS is a great implant option for contaminated or potentially contaminated field because it is safe and helps with minimal recurrence rate. This was determined through a study done by Morris et. al who implanted SIS into an infected field or a potential contaminated field. It was determined after a five year follow up that seven of the ninety-one-patient had recurrence and eleven had seromas that were resolved. Also, there was an internal image taken to determine if the SIS had been completely integrated or not. They determined that all except one patient was determined to have completely integrated SIS. The tissue consisted of strong scar tissue. In

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