This is a striking article on how peripheral catecholamine-O-methyl-transferase (COMT) gene expression is associated with obsessive-compulsive disorder in Han Chinese individuals with no consanguinity. Although the manuscript possesses numerous remarkable strengths, such as establishing the context and significance of the authors’ research, there are some areas, such as mentioning the limitations of the study, that require improvement for other researchers. The manuscript also has various issues that must be addressed before it is suitable for publishing. These include: 1. In the introduction, the author states that obsessive-compulsive disorder (OCD) affects 1-3% of the general population, when in fact it affects 2.3% of the general population. …show more content…
The introduction mentioned a “candidate gene approach,” which was not clearly explained for someone who is not very knowledgeable about this particular subject. The author could therefore clarify in more depth what it means, to make a stronger introduction. 3. The study objective should be more clearly articulated. For instance, the author should discuss why they examined the relationship between COMT and OCD using specifically real time quantitative reverse transcription polymerase chain reaction. The significance of this technique needed to be more well-defined. 4. The sample was taken out of a specific ethnic group, the Han Chinese. This fact can make it more difficult to generalize the results to a broader population, yet the purpose of choosing this specific group remains unclear. It would be good to clarify why this specific nationality was chosen as the sample. 5. In the method section, the actual group was interviewed by two psychiatrists, whereas the control group’s interviews were conducted by only one psychiatrist. The two groups should be interviewed by the same two psychiatrists in order to eliminate the issue of inter-rater reliability. The purpose for not doing this should therefore be reported and the consequences should be considered. This could be a potential confounding variable, which may mislead the
Obsessive Compulsive Disorder (OCD) is a pattern of recurring obsessions and compulsions that are severe enough to be time consuming and interfere with a person’s daily functioning. They must cause marked distress (such as pain or physical harm to the person) or significant impairment. Usually, they take more than
One out of every one-hundred children have this disease. Two point three percent of the world's population have OCD, that is three point three million people. OCD affects the brain which makes thoughts run over and over again, most of the time bad thoughts. OCD can make people’s thoughts and actions sometimes uncontrollable. Having tic disorders is a common sina fact of OCD, that is mostly what Cameron Diaz had, she hated germs. OCD can affect a lot of people, there is not much of a bad case, just the way you control it. She has done a lot to try and control
Obsessive-compulsive disorder involves a chemical imbalance in the brain. This chemical imbalance is thought to be the main reason for obsessions and compulsions, although there may be other factors as well. Nearly one in every fifty people suffers from symptoms of OCD ("Escape"), and approximately 5 million Americans are affected by
OCD is comprised of several different factors including those on the Yale-Brown Obsessive Compulsive Scale which are: the amount of time spent on compulsions, inference caused by compulsions to one’s daily activities, the distress caused by compulsions, the ability to resist the compulsion, and the control over the compulsion. By knowing which one of these factors are incorrectly represented by the model, one could work towards augmenting the model in such a way that it better depicts the symptoms and effects of OCD. Theoretically, this augmented model could be used to further research the implications of OCD and possibly develop methods or tools to assist those who suffer from the
Each participant met with a psychiatrist for a complete mental health assessment regardless of the hospital conducting one. This assessment sets the baseline for that participant. After the initial psychiatric evaluation each participant filled out a questionnaire that was created by the psychiatrist. Having a psychiatrist create the questionnaire gave the study validity, because the psychiatrist is a professional and expert in the area that was studied. Validity is necessary for good science and research.
Underestimated, unnoticed, and sometimes ignored, obsessive-compulsive disorder (OCD) lurks in the shadows of other illnesses. OCD is a mental condition that has severe to minor effects, but help is always available through Exposure with Response Prevention Therapy and medication. OCD obliterates the ability to think and live freely, leaving its victim trapped in a world of repetition.
Imagine feeling like a slave in your own body. Being forced to do ridiculous rituals and having constant compulsions to do things that you know don’t make sense. This is what it is like to live with Obsessive Compulsive Disorder (OCD). In the United States alone, over 2 million people suffer from OCD (Parks, 2011) but no one has found the cause of this disorder. It affects people of all races, genders and socioeconomic backgrounds (Parks, 2011). Since it’s discovery and modern conceptualization, there has been an ongoing debate whether OCD is caused by environmental factors or if it is inherited through genetics. However, since both sides of the debate raise a solid argument and there is not enough hard evidence, the source of the disorder
Obsessive Compulsive Personality Disorder (OCPD) is defined as a personality disorder that “as an extensive pattern of preoccupation with perfectionism, orderliness, and interpersonal and mental control, at the cost of efficiency, flexibility and openness (American Psychiatric Association 2013).” This disorder affects between 2-9% of the U.S. population, and symptoms begin to show throughout a person’s middle adulthood. It happens to be the most prevalent personality disorder in the United States, with 7.9% of the population being affected. Men are twice as likely to be diagnosed with this disorder. One study found that Hispanic and Asian ethnicities are less common to have this disorder in comparison to African American and Caucasian ethnicities.
Because victims of OCD realize their obsessive thoughts and behaviors are senseless and unnecessary, they may try to hide their problem. They fear people will think they are "crazy" or silly, and they may feel that they're all alone. Of course, nothing could be further from the truth. OCD affects as many as 2 percent of all Americans. Research indicates that, like depression and bipolar disorder, OCD is caused by an imbalance of the neurotransmitter called serotonin. This brain chemical, one of many that
Obsessive compulsion disorder (OCD) is an anxiety disorder described by irrational thoughts and fears (obsessions) that lead you to do repetitive tasks (compulsions) (Obsessive Compulsion Disorder, 2013). When a person has obsessive-compulsive disorder, they may realize that their obsessions aren't accurate, and they may try to overlook them but that only increases their suffering and worry. Eventually, you feel driven to perform compulsive acts to ease your stressful feelings. Obsessive-compulsive disorder is often driven by a reason, cause, or fear for example, a fear of germs. To calm the feeling of this fear, a person may compulsively wash their hands until they're sore and chapped. Despite their efforts, thoughts of obsessive-compulsive behavior keep coming back. This leads to more ritualistic behavior and a brutal cycle of obsessive-compulsive disorder. OCD is the fourth most common mental disorder, and is diagnosed nearly as often as asthma and diabetes (Who We Are, 2012). In the United States, one in 50 adults suffers from OCD. Obsessive compulsive disorder affects children, adolescents, and adults. About one third to one half of adults with OCD report a childhood onset of the disorder, they felt these anxieties but were not diagnosed or felt no need to be diagnosed until the compulsions over whelmed them (Who We Are, 2012). The phrase obsessive compulsive has been used to describe excessively meticulous, perfectionistic, absorbed, or otherwise fixated person. While
OCD is a brain disorder that may be caused by incorrect information processing. The three areas in the brain that are looked at are the Orbitofrontal cortex ,which is located in the prefrontal cortex above the eye, the caudate nucleus located near the basal ganglia, and the anterior cingulate cortex located in the front of the corpus callosum. Kring et al., (2014 ) states, the activity in these three places increase when people with OCD are shown objects that provoke symptoms. Other factors such as genetic, behavioral, environmental, and cognitive factors can trigger the disorder in an individual . It is not known which specific gene is inherited, but if a family member has OCD, their is a chance a child can have it. "Children who have family members with OCD have a greater chance of developing OCD early in life". (psychguides.com) One might have been conditioned as a young child to fear or become obsess by learning from ones' parent, which is the behavioral factor . The environmental factor can be caused because of a traumatic experience such as getting an illness like the flu. This type of traumatic experience can trigger OCD in a person in order to prevent from getting the illness again. The cognitive factor can cause individuals not knowing when to stop their obsessive thoughts and behaviors. According to Kring et al., (2014), people with OCD suffer in having a deficit in knowing when to stop their thoughts and behavior. They fail to gain the internal sense of completion , which it is defined as
Obsessive compulsive disorder (OCD) is a debilitating neuropsychiatric disorder with a lifetime prevalence of 2 to 3 percent and is estimated to be the 10th leading cause of disability in the world. Patients with OCD experience recurrent, intrusive thoughts (obsessions) and/or repetitive, stereotyped behaviors (compulsions) that last for at least one hour per day and significantly interfere with the individual 's normal level of functioning. The intrusive obsessional thoughts
To continue the research, Jordan Smoller distinguishes this section of the genetics of anxiety, “…the majority of the genetic association studies of the anxiety disorders have been candidate gene studies based on a limited number of biological hypotheses. [These are] commonly focused on genes related to monoaminergic neurotransmitter systems [(refer to the particular neurotransmitters dopamine, noradrenaline, and serotonin)], neuropeptides, and HPA axis function [(hypothalaic-pituitary-adrenal axis)]” (Smoller, p. 308). Individually, settled test creature models catch critical parts of human nervousness and dread conduct, and neuroimaging considers have gained free ground in mapping the primary and practical segments of uneasiness/fear symptoms.
Obsessive-compulsive disorder, or OCD, involves anxious thoughts or rituals one feels and can't control. . For many years, OCD was thought to be rare. The actual number of people with OCD was hidden, because people would hide their problem to avoid embarrassment. Some recent studies show that as many as 3 million Americans ages 18 to 54 may have OCD at any one time. This is about 2.3% of the people in this age group. It strikes men and women in approximately equal numbers and usually first appears in childhood, adolescence, or early adulthood. One-third of adults with OCD report having experienced their first symptoms as children. The course of the disease is variable. Symptoms may come
Obsessive Compulsive Disorder (OCD) is an anxiety disorder that is the fourth most common mental illness in the U.S. (8). OCD affects five million Americans, or one in five people (3). This is a serious mental disorder that causes people to think and act certain things repetitively in order to calm the anxiety produced by a certain fear. Unlike compulsive drinking or gambling, OCD compulsions do not give the person pleasure; rather, the rituals are performed to obtain relief from the discomfort caused by obsessions (2). OCD is more common than schizophrenia, bipolar disorder, or panic disorder, according to the National Institute of Mental Health (6). This disorder can be therapeutically treated, but not cured.