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Phototherapy: Light Therapy

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Phototherapy also known as light therapy involves the use of light to treat different diseases and disorders. The light can come from exposure to the sun or from lasers, light-emitting diodes (LEDs), fluorescent lights, and more. It has the ability to treat a wide range of diseases from skin conditions to eye problems to mood and sleep related disorders. Skin conditions that can be treated with light therapy include atopic dermatitis, vitiligo, and psoriasis while retinal conditions like diabetic retinopathy and diabetic macular edema can also be treated with phototherapy. Current treatments of seasonal affective disorders or sleep disorders continue to be researched and studied, but one of the best and most effective uses of light therapy …show more content…

Cremer in the Lancet. Dr. Cremer was the first pediatrician/general practitioner who first introduced people to using phototherapy to treat neonatal jaundice when he observed the falling values of bilirubin when the blood serum samples were exposed to light. Clinical trials in the 1960s confirmed Dr. Cremer’s findings and led to phototherapy being regularly prescribed for neonatal jaundice, saving millions of lives. It also proved to be extremely effective for low birth weight infants with jaundice, seeing the greatest rates of improvements.

B. Description
Neonatal jaundice is a disease which has been known since ancient times (figure _). It is visibly seen when bilirubin levels surpass 5 mg/dl (85 mmol/l) in the blood. Bilirubin is a waste product of fetal blood transitioning to adult blood and causes brain damage or even death when left untreated. It accumulates due to the inability of the undeveloped liver to process the waste product. According to the worldwide statistics, jaundice is detected in 60% of full-term babies and 80% of preterm babies. That’s between 60–70 million babies worldwide (1).

C. …show more content…

Symptoms of neonatal jaundice include excessive sleepiness, diet interference, and even brain damage in extreme cases. If the bilirubin blood concentration is too high, irreversible brain damage, and even death, can occur without treatment. Phototherapy causes this harmful bilirubin to absorb photons from light at around 450 nm and induces photochemical reactions, causing the formation of three major products that helps increase the elimination of bilirubin. Since bilirubin is often found to be bound to albumin, globular proteins that regulate the osmotic pressure of blood, the maximum absorption spectrum is actually shifted to the right into a range of about 450-475 nm. Visible light, specifically blue light falls within this range, which is why blue visible light is most effective in treatment neonatal jaundice. The photochemical reactions involve light shining on bilirubin, causing it to absorb photons and create bilirubin in an excited state. This photo-oxidation was widely thought to be the mechanism for bilirubin passage and excretion. However, in 1984, it was found that in fact isomer formation was the mechanism behind this excretion. Bilirubin undergoes from an insoluble cis- to soluble trans- conformation that allows the waste product to be eliminated through bile and urine. This is known as a figuration isomerization as known in figure

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