Pathophysiology Summary-Paget Disease Research Paper

1. Epidermoid cyst. Epidermoid cysts are the third most common benign subcutaneous tumor. They result from the proliferation of epidermal cells within a circumscribed space of the dermis. The epidermal inclusion cysts are usually well circumscribed, have a smooth surface, and are mobile.

tumors have invaded below the epidermis and into the dermis but are small and have no high

they had said that Ksol and Pelvic and HepB are all causes of the cancer and catches

The CDC reports that 10-15% of cases in women result in persistent infections, which can lead to cancers.

Trauma has been documented as a triggering factor in 10 to 20% of cases. Reports also describe tumour development in scars from previous operations, burn wounds, varicella or BGC immunizations, and rapid growth during pregnancy (due to progesterone receptors in the tumour). DFSP has been

Papillomatosis (multiple papillomas) is defined as a minimum of five clearly separate papillomas within a localized segment of breast tissue,. Multiple papillomas are more likely to occur bilaterally, and their probability of having an in situ or invasive carcinoma is higher than with the central papilloma. .(Guray and

Anogenital cancer (rectal, anal, anal canal, anorectum, penis and other genital) rates are on the rise with 27,660 estimated new male cases and 710 estimated male deaths in the United States last year alone.1 Currently, the Center for Disease Control (CDC) recommends vaccination in the men who have sex with men (MSM) population up to age 26 if they had not received it when they were younger.2 There are no current recommendations for this population who are greater than age 26 who have not previously received the vaccine. As age of an individual and number of lifetime sexual partners increases, the risk of developing anal cancer also increases. Men who have had >15 sexual partners during their lifetime show an increase in risk of developing anal cancer (OR=5.3; 95% CI, 2.4-12.0). Additionally, men who practice receptive anal intercourse is independently related to an increased risk of developing anal cancer (OR=6.8; 95% CI 1.4-33.8).3

Emerging evidence suggests that cutaneous HPV is associated with the risk for non-melanoma skin cancer. Before this association is further described, a brief note is presented on skin cancer. Normal skin consists of three layers, the epidermis, dermis and the sub-cutaneous layer.32 The epidermis is the top layer of the skin and consists of three main types of cells: squamous cells, which are constantly shed and replaced; basal cells, which constantly divide and replace shed squamous cells; and melanocytes which give color to skin. The dermis is the middle layer of skin that contains hair follicles, sweat glands, blood vessels, nerves and collagen fibers. The sub-cutaneous layer is the deepest layer and is composed mainly of fat cells.32,33

Hi Gi Hwa Shin, I appreciate your presentation on paget disease because you topic challenged me to review the literatures and recent studies. I did not see any patient with paget disease, even though it would be a good experience to share my knowledge.

Phyllodes tumors (PTs) are rare fibroepithelial tumors of the breast that tend to display a wide range of biological behaviors. They account for no more than 1% of all breast tumors and are called “phyllodes,” which means “leaf-like” in Greek language, because of the “leaf-like” pattern they grow in. However, they were called by over 60 different names before being given the official terminology of PTs by the World Health Organization.

For males the following diseases that can be prevented include genital warts, and the following cancers anal, throat, mouth, and penile (CDC, 2016). Cervical cancer from HPV are caused by HPV types 16 and 18 by 70%, anal cancer is caused by HPV type 16 by 95%, and throat and mouth cancer is caused by type 16 by 70% (NIH National Cancer Institute, 2016). Type 16 also causes cancer in the following areas vagina by 65%, vulva by 50%, and penile by 35% (NIH National Cancer Institute,

Because there is often extensive osseous involvement and because individual areas progress at variable rates, Paget disease of differing phases may be seen in the same patient. The end result is a thickened, disorganized trabecular pattern of bone, referred to as a “mosaic” or “jigsaw” pattern .Cement lines along the coarsened and enlarged trabeculae are characteristically seen; these lines represent osseous resorption and bone formation . The trabecular areas of thickening usually lack the interconnection seen in normal bone and thus are weakened and often referred to as “pumice” bone

Carcinoma - this is the cancer that originates in the skin and tissues and progresses to cover internal organs. Some subtypes of carcinoma include adrenocarcinoma, basal cell carcinoma, squamous cell carcinoma and transitional cell carcinoma.

Also, Human Immunodeficiency Virus (HIV) increases the likelihood of the precancerous cells developing into cancer. This occurs because HIV weakens the immune system, and a woman with HIV is unable to fight off HPV and precancerous abnormalities (2). Scientists have also found that smokers are possibly twice as likely to develop cervical cancer. Cigarettes release many chemicals that cause cancer (1). When a woman smokes a cigarette, these chemicals enter her bloodstream, and they are carried to all parts of the body. These chemicals are also believed to damage the DNA in cervical cells (2). Scientists are also examining the effects of Oral Contraceptives. No direct links have been found, but there is some statistical evidence showing that women that have taken Oral Contraceptives for over five years have a low risk of developing the cancer (2).

Cervical cancer malignant cancer of the cervix uteris or cervical area. It may present with vaginal bleeding but symptoms may be absent until the cancer is in its advanced stages, which has made cervical cancer the focus of intense screening efforts using the Pap smear. About 2.2 percent of women carry one of the 2 virus strains most likely to lead to cervical cancer. One of the symptoms of Cervical Cancer is very Unusual amount of discharge.