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Opioid Theory Paper

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As mentioned briefly before, the placebo analgesia mechanism might work through the release of endogenous opioid analgesics, the body’s natural narcotics that are produced as a reaction to stress and pain. The reason for this belief is that studies have shown that naloxone, a narcotic antagonist, reduces the pain-killing effects of placebos. (2) (21) (22) Despite the fact that other studies have not found naloxone to have any effects on placebo responses, (23) (24) the opioid theory is the most widely accepted theory when it comes to the explanation of placebo pain-reduction. In opioid analgesia, the rostral anterior cingulate cortex (rACC) shows a high activity, as this brain region has many opioid receptors. If the placebo analgesia really

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