Overview
Obesity in terms of measurement is a body mass index (BMI) of greater than 30. Health care professionals and most individuals understand obesity has many implications on one’s health. It is estimated that 78 million, nearly 36% of Americans, are obese (Yanovski & Yanovski, 2015). In a stark contrast, given the number of obese people in the US, approximately only 2.74 million patients were reported to use any type of obesity medications (Shinn & Gadde, 2013). Many barriers exist as to why there is such a small percentage of participants using any form of antiobesity medication: safety concerns, costs, limited efficacy, participants reluctance to view obesity as a diagnosis that would require medical intervention (Shin & Gadde, 2013).
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Mayo Clinic gives the example of a patient weighing 200 pounds and being labeled obese according to BMI standards; this patient would only need to shed 6 to 10 pounds to begin noticing small yet beneficial health improvements (Mayo Clinic, 2015). The National Institutes of Health (NIH) stated that with a reduction of 10% of body weight, obese patients will lower their risk in developing additional medical conditions such as high blood pressure, type 2 diabetes, high cholesterol, while making a positive change in their overall health (Vivus, 2012). There is a never ending supply of articles, websites, fitness magazines, nutritional supplement companies, gym memberships, workout videos, recipes for reducing caloric intake, counseling programs, hypnotists, support groups, and surgical interventions that all address reducing weight. For the sake of this topic, this paper will address pharmacological interventions as a way for weight reduction, what medications are currently being used as well as a new drug combination of phentermine and topiramate (Qsymia) being used for the treatment of …show more content…
A 56-week trial with 1267 randomized participants having a BMI > 35 (Shin & Gadde, 2013). Participants did not have significan comorbidities and were treated with either a low-dose PHEN/TPM (3.7/23mg), full-dose PHEN/TPM (15/92mg), or placebo (Shinn & Gadde, 2013).
Group 3. The largest of the clinical trails, had 2487 participants either overweight or obese with a recorded BMI of 27 – 45 and having 2 or more obesity related comorbidities: hypertension, type 2 diabetes, dyslipidemia, abdominal obesity, or prediabetes (Shin & Gadde, 2013). Shin & Gadde identified the five main concerns the FDA focused of during the course of the PHEN/TPM trial: teratogenicity, cardiovascular, cognitive, psychiatric and metabolic acidosis (2013). In regards to teratogenicity, there are reports indentifying a higher chance of cleft lip and cleft palates among infants whose mother’s had taken TPM during her pregnancy (Shin & Gadde, 2013). Another concern regarding TPM is that there may be interference with oral contraceptives, which may lead to the failure of the contraceptive protection (Shin & Gadde, 2013). In this trial there was a small increase in heart rate of participants between .6 and 1.6 bpm and there was not an increase in major adverse cardiac events when comparing PHEN/TPM and the placebo (Shinn & Gadde,
Obesity is becoming an increasingly significant health concern in the United States, nearly to the point of epidemic proportions. To be considered obese, one’s body weight must be at least 20% over their ideal body weight; unfortunately with this definition, over 30% of all Americans are obese. Alarmingly, approximately
Obesity remains an extremely serious issue worldwide. Once considered a problem for wealthier counties, overweight and obesity are now dramatically increasing in low and middle income countries (WHO, 2011). In American, the rates of obesity continue to soar. CDC (2009) recognizes obesity as a risk factor for diabetes, heart disease, high blood pressure, and other health problems. According to NHANES over two-thirds of the US are overweight or obese, and over one-third are obese (CDC, 2009). Treatment for this illness varies; it may include the incorporation of diet, exercise, behavior modification, medication, and surgery. Since there is no single cause of all overweight and obesity, there is no single way to prevent or treat overweight
Since the beginning of time, weight loss has been a concern for people throughout the world. In the Nineties, it has become the focus of numerous advertisements, articles, and media scams. Infomercials selling everything from exercise equipment to magical creams promising results of cellulite-free thighs are plastered across late-night television in perfect view for anyone. Along with all of this, diet pills once again became the fad in 1994 with phen/fen. This was the first time since the 1960s. Then, in 1996 Redux hit the market (http://www.mesomorphosis.com/obesityclinics.htm). The advertisements for these pills were aimed towards those people who were obese and wanted
In order to identify a condition as a disease, it should fit certain criteria. One of the reasons that obesity is classified as a disease is because of its large comorbidity. Obesity is a risk factor for chronic diseases such as hypertension, dyslipidaemia, type 2 diabetes, cardiovascular disease, sleep apnoea, musculoskeletal disorders and some cancers (Rossner, 2002). According to Rossner (2002), the death rate from all causes, cardiovascular disease, cancer and other diseases increases among moderate and severe overweight men and women in all age groups. Therefore, obesity is
Consequently, the result of this negative trend caused obesity to be the second leading cause of preventable deaths with 18% of American adults dying each year (CDC, 2016). According to the National Institute of Diabetes and Digestive and Kidney Diseases “more than one-third (35.7%) of adults are considered obese. More than 1 in 20 (6.3%) have extreme obesity” (NIDDK, 2012).
Obesity is a weight disorder that affects more people every year and poses serious health risks. Obesity can give way to further health conditions such as stroke, heart disease, type 2 diabetes and some forms of cancer. In the United States more than 78.6 million adults are obese; and in 2008, the estimated medical costs of obesity in the United States totaled $147 billion (USD), according to the Centers for Disease Control and Prevention. As the rising costs and consequences of obesity continue to expand, more alternatives to aid in weight loss could help to improve patient outcomes. Does 3.0 mg of once-daily
Compared to other countries, the United States was reported to have the second highest rate of obesity in the world after Mexico. Over the past decade, cases of obesity have triplicated in the U.S., affecting more than one-third (34.9% or 78.6 million) of the adults (Ogden et al. 2014). Given the current trends, it is projected that 42% of the U.S. population will be obese by 2030 (Finkelstein et al. 2012). Aside from its nefarious impact on the overall quality of life of the affected individual on a micro level, obesity has an enormous economist cost on the US healthcare system. In their extensive annual medical spending report, Finkelstein et al. (2012) indicated that the annual medical cost for obesity in the US amount to $147 billion
The purpose of this qualitative study was to evaluate the determinants of dieting and non-dieting strategies based on the perspectives and experiences of obese patients. The participants were between the age group of 25-70 years, with the BMI above 25. The authors selected randomly 21 participants who met the criteria and conducted a semi-structured face-face and phone interviews to gather detailed individual experiences and perspectives. In the interview, the participants were asked to explain the experiences related to being obese as well as weight loss, the effects of overweight on their life and health status and their concepts regarding food and exercise. Also, data was collected about established diets if any and adoption of non-dieting
Obesity, the condition of being severely overweight, is a serious issue in the United States that is gradually beginning to affect more and more citizens. In recent years, the number of Americans suffering from this chronic disease has significantly increased. Researchers have found that nearly one third of the U.S. population is considered overweight and, on average, three hundred thousand individuals die yearly as a result of obesity (Hollands et al. 2). When one participates in little to no physical activity and their diet consists mostly of high fat foods, chances are they will gain weight. If someone becomes obese, they may develop serious health related issues that, in some cases,
“Obesity is a disease that affects more than one-third of the U.S adult population (approximately 78.6 million Americans). The number of Americans with obesity had steadily increase since 1960, a trend that has slowed down in recent years but show no sign of reversing”.
Obesity rates in the United States are alarming, with more than one-third of U.S. adults and 17% of children qualifying as obese with a Body Mass Index greater than 30.0 (Centers for Disease Control (CDC), 2015). Even more frightening is the growth rate of this crippling health epidemic; between 1980 and 2014, obesity has doubled for adults and tripled for children (CDC, 2015). The physical consequences of rising obesity rates in our country include an abundance of physical ailments including type-2 diabetes, cardiovascular disease, sleep apnea, arthritis, elevated cholesterol, and even some cancers. Additionally, obesity-related health care costs to our country are estimated at $147 billion annually, plus the costs of productivity lost at
James, W. P. (2008). The epidemiology of obesity: the size of the problem. Journal of Internal Medicine, 336-352. Retrieved from http://eds.a.ebscohost.com.library.gcu.edu:2048/ehost/pdfviewer/pdfviewer?sid=9ede2d6d-4d02-42e9-aff7-dd9b2486a3c3%40sessionmgr4004&vid=8&h
Standardized questionnaire, physical examination, and laboratory tests were included in this survey. Specially trained doctors and nurses performed all data collections. A face-to-face interview was conducted to collect demographic (e.g. age and gender) and clinical data (e.g. smoking status, alcohol consumption level, exercise habits, history of diabetes mellitus, history of hypertension and use of antihypertensive drugs) by self-reporting, standardized questionnaires. As in our previous study, physical examinations involved assessments of height, weight, and waist circumference 11-12-. BMI was calculated using the following formula: weight/height2 (kg/m2). Fasting plasma glucose (FPG), fasting serum total cholesterol (TC), low-density lipoprotein
Source: CDC, National Center for Health Statistics, National Health and Nutrition Examination Survey. Health, United States, 2002. Flegal et. al. JAMA. 2002;288:1723-7. NIH, National Heart, Lung, and Blood Institute, Clinical Guidelines on the Identification, Evaluation and Treatment of Overweight and Obesity in Adults, 1998.
A placebo-based study performed at Cardiff University (UK) included 755 participants, over 4-months, at 3–5 doses, daily.