Non Small Cell Lung Cancer Research Paper

What are lung cancers? Lung cancers are the abnormal cells which grow in uncontrolled manner in one or both lungs. They do not function as normal lung cells and do not develop into healthy lung tissue. The abnormal cells can grow, form tumours and interfere with the normal functions of the lung (Lungcancer.org, 2015). Lung cancers can be divided into two major types, namely non-small cell lung cancers (NSCLC) and small cell lung cancers (SCLC). NSCLC can be further classified into three main subtypes, namely adenocarcinoma, squamous-cell carcinoma and large-cell carcinoma (Longo & Harrison, 2012). Lung cancers can be diagnosed by chest X-ray, computerised tomography (CT) scan, positron emission tomography-computerised tomography (PET-CT) scan, bronchoscopy and biopsy (Nhs.uk, 2015). Unfortunately, lung cancers are often diagnosed at the later stages. This is due to the unrecognisable symptoms and warning signs at the earlier stages. NSCLC are often diagnosed at stage IV which accounts for 30-40% of cases whereas 60% of SCLC is diagnosed at stage IV. Lung cancer usually originates from the cells lining the bronchi, bronchioles and alveoli. Carcinogens especially tobacco smoke will alter the gene expression of the normal human lung cells, resulting in cell mutation. The proto-oncogenes will be converted to mutated form, oncogenes. Mutation leads to the decreased expression of the tumour suppressor genes. This results in uncontrolled cell proliferation, cell

Cancer, it can affect anyone; it can affect any part of the body but what is it? Cancer results from the abnormality in the body's cells. This occurs when the cells divided and grow. Disruption in the system of the growth and division of a cell results in an uncontrolled division and proliferation of cells that form a mass which leads to cancer. The patient outcome for cancer is different for everyone, but it is also different with each type. In the respiratory department, a major type of cancer we will deal with is lung cancer. Lung cancer, however, has different types and stages, but for this paper, we are going to talk about Stage IIIA non-small cell lung cancer (NSCLC). In the article titled “Stage IIIA Non-Small Cell Lung Cancer” it states

Beneath the lungs, a slender, arch formed muscle called the stomach isolates the mid-section from the guts. When you inhale, the stomach climbs and down, compelling air all through the lungs. Lung tumor begins when cells of the lung get to be anomalous and start to become crazy. As more disease cells create, they can frame into a tumor and spread to different regions of the body. Non-little cell lung growth is a gathering of lung tumors that act likewise, for example, squamous cell carcinoma and adenocarcinoma. Side effects are a hack that won't leave, shortness of breath, weight reduction, or hacking up blood. Medicines incorporate surgery, chemotherapy, and radiation. Lung disease begins when cells of the lung get to be strange and start to become crazy. As more malignancy cells create, they can frame into a tumor and spread to different ranges of the body. Around 80% to 85% of lung growths are non-little cell lung malignancy (NSCLC). There are subtypes of NSCLC, which begin from various sorts of lung cells. Be that as it may, they are assembled together as NSCLC on the grounds that the way to deal with treatment and guess are regularly

It is wise, however, to have a doctor monitor the tumor over at least a two-years period in order to note any changes that might indicate the presence of cancer. Also, a biopsy or surgical removal of a tumor may be needed when the patient is a smoker, the patient has difficulty breathing, or other troubling symptoms, tests show that the cancer could be present, and the nodule continue to grow. The malignant lung cancer is divided into non- small cell lung cancer, small cell lung cancer, and lung carcinoid tumor. First, the non- small lung cancer is A group of lung cancers that are named for the kinds of cells found in the cancer and how the cells look under a microscope. The cancer cells of each type grow and spread in different ways. The three main types of non-small cell lung cancer are squamous cell carcinoma, large cell carcinoma, and adenocarcinoma. Non-small cell lung cancer is the most common kind of lung cancer. The first type of the non- small cell cancer is squamous cell carcinoma About 25% to 30% of all lung cancers are squamous cell carcinomas. These cancers start in early versions of squamous cells, which are flat cells that line the inside of the airways in the lungs. They are often linked to a history of smoking and tend to be found in the central part of the lungs, near a main airway (bronchus). The second type is larger cell carcinoma this type accounts for about 10% to 15% of lung cancers. It can appear in any part of the lung. It tends to grow and spread quickly, which can make it harder to treat. A subtype of large cell carcinoma, known as large cell, neuroendocrine carcinoma, is a fast-growing cancer that is very similar to small cell lung cancer. The third type of non- small cell lung cancer is adenocarcinoma about 40% of lung cancers are adenocarcinomas. that begins in the cells that line the alveoli and make substances such as

The theme of this journal article was to explain to the audience the various sub types of non-small cell lung cancer, its risk factors, and the different procedures a patient has to undergo in order for them to be diagnosed with cancer. It does a great job answering a vast amount of questions the audience can have regarding the disease itself, the procedures used for prognosis and diagnosis of non-small cell lung cancer, and/ or the treatment available for patients with this disease. Overall, this report was very well detailed and provided the audience with a lot of

Lung cancer is the most common cause of death from cancer, across the globe. More deaths are reported from lung cancer than that from breast, colon or prostate combined (2). Around 80% of lung cancers are determined to be non-small cell lung cancer (NSCLC) and 65% of those patients have advanced or metastatic disease when discovered (11). Research has shown that early diagnosis and accurate staging is the cornerstone for improving survival of patients with lung cancer. Treatment options depend on the severity of the disease, making accurate staging a priority (7).

This paper discusses in distinct detail the pathology of lung cancer, specifically malignant tumors. This investigation into the cancer touches on many different subjects that include: the history of the disease and how it came to be so prevalent, it’s cellular origins, how it is diagnosed within a patient, the different treatments used to fight it, and the survival rates for people with any sort of lung cancer. The paper also goes in depth about the use of x-rays and how they are used to find lung cancer. There are many resources used for this paper and they are cited as necessary.

The symptoms of non-small-cell lung cancer is hard to be noticed in the early stages,

Lung cancer mainly occurs in older people, but may occur in younger people as well. Many people who are diagnosed with lung cancer do not live passed the 5 year survival rate. People with stage 4 who make it passed the one year mark with stage 4 lung cancer often lucky. There are several lung cancer risks. Many people may experience a cough that does not go away or gets worse. The person may have chest pain that is often worse when taking a deep breath. The cough and chest pain are often mistaken for pneumonia. The person may experience weight loss and loss of appetite. In the late stages the person may have shortness of breath and feel tired or weak. Lung cancer could be diagnosed in a variety of ways. Lung cancer is often found when the person is having signs or symptoms. X-rays, magnetic fields, sound waves, or radioactive substances create pictures of the inside of your body. Imaging tests may be done for a number of reasons both before and after a diagnosis of lung cancer (cancer.org). X rays may not be able to pick up lung cancer sometimes so it is best to use another imaging test. A cat scan is more likely to show images of a tumor than a chest x

A doctor can diagnose lung cancer through many tests. The doctor can have x-rays and CAT scans done to see what the inside of the lungs look like. By doing this that doctor is able to see what stage the cancer is in. A doctor may also do a test called a bronchoscope. This test allows the doctor to look inside the bronchial tubes and biopsy the tumor. The doctor then can take a small amount of the cells to study them to determine if the unusual cells are cancerous. If the cells turn out to be cancerous then the patient is in for many months even years of harsh treatment.

In this text I will be talking about SCLC(small cell lung cancer) and not NSCLC (non small cell lung cancer), the two main lung cancers. (according to www.lung.org) SCLC makes up 20% of all lung cancer cases and most associated with smoking. NSCLC makes up the other 80% of lung cancer cases but does not spread as fast as SCLC. NSCLC Comprises of: Adenocarcinoma, Squamous cell carcinoma,Large cell carcinoma.

There happens to be 4 different stages for this type of cancer. !st stage the cancer stays in the lungs and tumor smaller than 2 inches. 2nd stage the tumor grows more than 2 inches and it spreads to nearby structures. One being lymph nodes. 3rd stage tumor may be very large and spread further. Stage 4 is where the cancer spreads to the other lung or other areas of the

The survival advantage for those who stopped smoking was adjusted for demographics, disease stage and other health characteristics.” (science daily). 90-95% of lung cancers diagnosed are found in the lungs because of the epithelial cells (medicine.net). Lung cancer is the most leading death in the US and the world (medicine.net). There are many ways to prevent lung cancer, some ways are as follows: reduce/quit smoking; cigarettes have over 600 chemical ingredients and when lit, over 4000 chemicals are released into your body. After two to four months of being diagnosed with SCLC, more than half of the patients die (medicine.net). However, after 5 years of diagnosis, patients survival rate is down to 5-10% (medicine.net). NSCLC has the best survival rate at 75% after 5 years (medicine.net). The reason why the survival rate is so high for NSCLC is because the lung can be treated upon with different procedures and the cancer spreads slowly throughout the body. “The overall prognosis for lung cancer is poor when compared with some other cancers. Survival rates for lung cancer are generally lower than those for most cancers, with an overall five-year survival rate for lung cancer of about 17% compared to 67% for colon cancer, 90% for breast cancer, 81% for bladder cancer, and over 99% for prostate cancer.”

Lung cancer is one of the leading causes of death not only in the United States of America but globally.1 According to the World Health Organization 8.2 million deaths in 2012 were cancer related and of those deaths, 1.59 million were due specifically to lung cancer.2 In 2014, there was a staggering 224,210 new reported cases of lung cancer in the United States alone. The 5-year relative survival has a 49% to 2% variability depending on the type of lung cancer, stage, and location. The two major types of lung cancer are Non-small cell lung cancer (NSCL), which consists of 85% lung cancers, and small cell lung cancer (SCLC), which makes up the other 15% of lung cancers. NSCL is an epithelial lung cancer that is histologically comprised of adenocarcinoma, large cell carcinoma, and squamous cell carcinoma.1 Both NSCL and SCLC are insidious in nature and the presentation will usually be vague or nonspecific and include the following symptoms: cough, shortness of breath, fatigue, weight loss, recurrent infections, coughing up blood, hoarseness, and wheezing.

Lung cancer is the leading cause of cancer-related mortalities in the world. An astounding average of 1.6 million deaths occur due to lung cancer yearly (1). Lung cancer is classified into two types: small cell and non-small cell lung carcinoma (NSCLC), where 85% of lung cancer cases are NSCLC. NSCLC has several different histologic subtypes, some of which are: squamous cell carcinoma, large cell carcinoma, and adenocarcinoma. Of the three, adenocarcinoma accounts for more than 50% of NSCLCs, making it the most common subtype (2).