Mir200 Family Essay

As you already know, Chronic Obstructive Pulmonary Disease (COPD), manifests itself when the passageway of air to the lungs is severely obstructed, thus preventing sufficient flow of oxygen into the bloodstream.1 The pathophysiology of COPD is a complex process that is the result of multiple airway diseases that simultaneously contribute to the impairment of airflow in the lungs.1 Specifically, the overlapping outcome of chronic bronchitis and emphysema is the pathogenesis of COPD.1 The risk factor for the COPD is influenced by the individual’s genetics, age, gender, exposure to air pollution, socioeconomic status, and the use of tobacco products.1 The use of tobacco products can increase the development of COPD.1 However, individuals that don’t smoke can also attain COPD.1 Therefore, COPD is not exclusive to individuals that smoke on a daily basis.1 In fact, genetics and the natural aging process plays a part in the development of pulmonary issues.1 For example, it has been proven that a deficiency in the alpha -1 antitrypsin gene is correlated with the development of COPD.1 The natural deterioration of lung tissue, coupled with the long term exposure to environmental elements, explains why the risk of attaining COPD increases as one progresses to the latter stages of their lives.1 In a healthy individual, goblet cells secrete about one liter of mucous that provides a moist surface over the lungs, trachea, and esophagus.1 The cilia on the pseuodocolumnar epithelial cells continuously sweep the mucus in the lungs in an upward motion.1 The cilia sweeps the mucosal trapped debris up, and removes pathogens and other foreign particles out the pulmonary tissue.1 In individuals with COPD, the pathogenesis of the disease creates structural modifications of the lung tissue, which result in deformed and nonfunctioning cilia.2 The lack of functioning cilia leads to the buildup of mucous, pathogens, and subsequent respiratory infections.2 Furthermore, the body tries to combat

Cystic fibrosis is an genetic disease that can cause bad damage to the lungs and other organs in the body. It is a common genetic (Gene) disease affecting to geriatric, (adults) young adults, or and kids. Now they’re still searching for a cure, but the only thing that is currently available is a donor’s lungs.

In Ronald Bailey’s article “Transhumanism: The Most Dangerous Idea? Why Striving to Be More Human Is Human”, Bailey poses an underlying question about which ideas, if embraced, would pose the greatest threat to the welfare of humanity? In particular, Bailey posed the question to 8 of the most prominent policy intellectuals editors of the “foreign policy” from the September and October issue. Of the 8 editors, the answer that caught Bailey’s attention the most was that of editor Francis Fukuyama. Fukuyama proposed in his Foreign “Policy article”, that the world’s most dangerous idea was that of Transhumanism.

“I gripped the reed and wires and waited for the miracle. Finally it came, at first a tiny light that flickered from my palm, then a surging magnificent glow. The crowd gasped and shuddered.” (Kamkwamba, 2). William cannot be described with only three traits, but I will try my best. In the book, William shows perseverance, ingenuity, and resourcefulness. The fact that he could take an idea and create a source of energy is astonishing. Even through the famine and through doubt his peers, he managed to create a masterpiece.

Since the cloning of ABCC1 in the early 90s [14,15], progress has been made towards establishing a functional relationship between ABCC1 and CFTR. For example, functional complementation of dysfunctional CFTR by ABCC1 following chemotherapy that resulted in increased expression of ABCC1, was associated with improved lung function in a CF patient [12]. A study analyzing nasal epithelial cells in CF patients also showed that low ABCC1 transcript levels were associated with more

Each year about 42,000 more people aged 65 and older are diagnosed with IPF. Idiopathic pulmonary fibrosis affects more men than women. Most people who have Idiopathic Pulmonary Fibrosis are over 50 years old typically, but not always. It is progressive, unpredictable, and irreversible. The damage it does to the lungs cannot be undone. There are treatment options that may help slow its progression, but ultimately there is no cure. IPF is a progressive disease, which means that over time the scarring becomes more widespread and lung function declines. Doctors can’t predict how quickly this will happen. IPF progresses rapidly for some people and slowly for others. People who have a lung transplant have a mortality rate of about 50% to 56% after five years. Staging systems for idiopathic pulmonary fibrosis may help health-care professionals and researchers to better define the medical condition of their patients. However, for idiopathic pulmonary fibrosis, staging systems are constantly being redefined. For example, the first staging systems traditionally considered the disease as mild, moderate, or severe while others considered stages as early or advanced. The stages are kind of impulsive and loosely based on pulmonary function tests. Unfortunately, there are no standardized definitions for mild, moderate, and severe idiopathic pulmonary fibrosis. In addition to testing

Idiopathic pulmonary fibrosis (IPF) is a fatal irreversible disease that severely diminishes lung function. IPF is part of a 200 + lung disease group known as interstitial lung diseases (ILD). The ILD group of diseases adversely affects the interstitium, which is the interstitial space between the lung tissue and air sacs. IPF is characterized by the scarring and honeycombing of the lung tissue and the accretion of fibrosis. The word 'idiopathic' is derived from the Greek word ‘idios’, which means 'of unknown cause' and aptly explain the status of the prognosis of this deadly disease. Some of the symptoms of IPF is shortness of breath (dyspnea), crackling sound in the lungs, finger clubbing and unrelenting dry cough.

|Specific Purpose: |To inform readers on the causes, effects and treatments of lung cancer. |

MDI exposure route in the occupational environment is thought to be mostly through inhalation and dermal contact {NIOSH, 2004 #145}. At room temperature, MDI is not volatile (with vapor pressure approximately at 10-5 mm Hg). During application, MDI is usually heated and/or aerosolized via a spray gun, thus generating repairable vapor and/or aerosols to allow inhalation into the lung. To mimic this MDI airway exposure route, we developed a nose-only aerosol exposure mouse model {Hettick, 2017 #179} to examine whether circulating mmu-miRs-183-5p, -206-3p, and -381-3p identified from MDI dermal exposure group could serve as potential biomarkers for the airway exposure route of MDI. Compare to mice exposed to house air only, mmu-miR-183-5p were upregulated 16.47-fold in serum collected at 4 hours (4h) after MDI-dust exposure and 41.57-fold in serum collected at 24 hours (24h)

Idiopathic pulmonary fibrosis (IPF) is a very devistating diagnosis that is associated with scarring and thickening of the lung tissue, making breathing a difficult task for patients (Bridges et al., 2014). Without a known cause, IPF progessively affects a patient’s lung fuction presenting as dyspnea, cough, and fatigue (Yount et al., 2016). This disease robs individuals of their quality of life, and their lifespan. Accoriding to (Bridges et al., 2014), an average lifespan of a patient after diagnosis is approximately three to five years. These patients lack independece in their normal everyday activities, their physical functioning declines, along with their respiratory function. Relief is sought through limited available interventions that

enzymes are released to destroy foreign microbes and irritants such as cigarette smoke, air pollution,

The sample from this study was 220 individuals who presented with IPF and were ages fifty and older who had not already received a lung transplant (Yount et.al, 2016).

Approximately 445 million dollars are spent on acute hospital stays for chronic obstructive pulmonary disease in Canada, not including ongoing care and prescription drugs (Leading Hospitalization Costs in Acute Inpatient Facilities in 2012–2013). A majority of this money is spent on treating patient’s symptoms, not their condition. A use for stem cells and regenerative medicine is to treat asthma, “Since it has been described that asthma is a disease of T cell hyperactivity and scarring, hMSCs may provide a viable multiaction therapeutic either directly through cell contact or through the production of bioactive factors,” (Bonfield). Despite asthma being a common condition, it follows people their entire life, and results in less productivity during a flare up. The use of stem cells to treat asthma may limit the prescriptions required to prevent a flare up, as well as allow easy breathing for asthma patients. Diabetes is a growing problem in society; however, stem cells may be able to correct the absence of insulin: “with in vivo virus-mediated expression of specific transcription factors in differentiated pancreatic exocrine cells resulting in the reprogramming of these cells into pancreatic β-like cells.” (Atala). While this new innovation could save the government money on insulin, it could also improve the quality of life for millions, and eradicate diabetes. Another application of stem cell research is to treat leukemia: “Another promising approach is the isolation and genetic modification of patients’ cells to target or enhance the efficacy of a cellular therapy. One example of this approach is the development of targeted immunotherapy for B-cell malignancies.” (Atala). This approach can counteract the irregularity of the blood cells, and provide a cure to this cancer. With the current knowledge of stem cells their curative potential seems

The purpose of this essay is to describe my personal experiences during my part on the family assessment and goal planning which was the section pertaining to me specifically. Additionally, I will reflect over the family experience as opposed to the Dyad. I will analyze my expectations of the assignment prior to starting it and my perception after finalizing it. I will touch base on my experience while role-playing as both part of the family and as the social worker portion of the experience. Lastly, I will summarize my strengths and weaknesses and the areas of growth I identify that I need to develop as I see it fit to my professional growth.

Lesions of lungs comprise lymphangioleiomyomatosis (LAM) and multinodular multifocal pneumocystis hyperplasia (MMPH) which are present in round 1/3 mature women and rarely in males [1]. AML cells can migrate to the lungs causing proliferation of smooth muscle and progressive destruction of pulmonary parenchyma, resulting in a potentially fatal pulmonary disease known as lymphangioleiomyomatosis (LAM) [9].