Melanoma Outline

Melanoma is caused by over exposure to UV which can sometimes cause sunburn, it can be especially critical to those whom are inclined to the disease itself. The tumours derive in the pigment-producing melanocytes which are inside the basal layer of the

The submitted records have been reviewed. The member is an adult female with a birth date of 07/01/1987. She has a diagnosis of cutaneous melanoma. Her treating provider, Semyon Zarkhin, MD recommended DecisionDX Melanoma testing, which was performed on 11/23/2015.

Acral Lentiginous Melanoma or ALM is a rare subtype of melanoma that occurs more often in people of color. It accounts for 2 to 3 percent of the all of the world’s cases of melanoma (Bradford). Dr. R. J. Reed in 1976 was the first to describe it as the appearance of dark lesions on the hands and feet. Radial or lentiginous was the main phase of its growth that lasts several years then it changes into a vertical or dermal invasive stage (Bradford). Several universities have released results on tests on ALM but since it is rare it was difficult for the research groups to get solid information because of small sample sizes. Nonetheless, studies by scientists such as Dr. R. J. Reed we able to determine that the survival rate for three years with the melanoma was on average at 11% (Bradford).

Although there are several types of skin cancer, the most aggressive form is melanoma. This cancer of the skin involves mass replication of the pigment producing melanocyte cells, which are located in the epidermis, below the basal layer. There are several factors involved with the onset of melanoma including, exposure to ultraviolet rays, genetic predisposition, numerous nevi (moles), immunosuppression, and environmental exposure to carcinogens.

Melanoma is a dangerous invasive cancer which starts in melanin producing cells (melanocytes) usually located at the bottom of the skins epidermal layer. Although certain individuals have a genetic propensity for melanoma, it is usually triggered by excessive UV exposure from sunlight or tanning beds (Mayo Clinic, 2016a). At early stages it is relatively easy to treat, however, recurrences are common. At later stages melanoma treatments are less effective since it tends to metastasize and spread easily through the lymphatic system (Mayo Clinic, 2016a).. The root cause of malignant melanoma is due to mutations in the p53 gene protein which invariably leads to further mutations.

Melanoma is the most dangerous type of skin cancer. It develops when unrepaired DNA damage to your skin cells trigger genetic defects that lead you skin cells to multiply at a fast pace and form tumors. Melanoma can often resemble moles and some can come from previous moles. These melanoma moles can range in color from pink, red, brown, purple, white, blue and skin-colored, but more mostly seen as black or brown. It’s said that consumers who use indoor ultraviolent tanning devices are seven-four percent more likely to develop melanoma compared to someone who has never used a tanning bed before. Melanoma is usually caused from intense and over exposure to UV radiation. It has be estimated to kill around 10,000 individuals in the U.S. each year. The lifetime risk of melanoma is 1.5 times higher in males than in females. Melanoma is curable, if it is recognized early and

     Distinguishing melanoma may seem hard to do, but is not so once a person is informed on what they should be looking for. They may appear similar to moles, and may be blue or black in color. Though they will usually lack the symmetry and border regularity of a common mole, and may have variance in their coloring. Melanomas can either appear suddenly, or develop slowly near a preexisting mole. In rare cases, melanomas may form on top of previously formed moles or birthmarks, but will also come with the effects of pain, itching, or bleeding. These moles may begin to exhibit new and/or strange characteristics such as

The article “Melanoma: Causes, Symptoms, and Treatments” written by Markus MacGill and reviewed by Dr. Helen Webberley is exactly what it states, an article on the integumentary disease melanoma. This article tells everything about melanoma, stating that it is a very deadly type of skin cancer. It is fortunate that it is the least common, however it is still responsible for the majority of skin cancer related deaths each year. Melanoma comes from pigment-producing cells that have mutated into a cancerous cell. They spread quickly, almost too quickly to catch. Skin cancer is first noticed by the look of the skin, then can be confirmed or denied with testing. Melanoma may not produce symptoms. Staying out of the sun for extended amounts of time is best when avoiding skin problems, especially skin cancer. Melanoma is seen mostly in people over the age of forty, and favors women. It can develop anywhere on the skin but does favor the trunk of men and the legs of women. Melanoma will form changes in existing moles on the skin. People should be checking for noticeable differences in skin constantly, especially those who have a known risk. Some early indicators of melanoma could be pale skin, light eyes, numerous moles, multiple freckles, sun exposure, light hair, age, and a few more. Sadly, most these are unavoidable.

Skin Cancer is the abnormal division of skin cells which cause tumors in the body. There are 3 types of Skin Cancer: Melanoma, Basal cell carcinoma, and squamous cell carcinoma (Web Md, year). Skin cancer is caused by the exposure of ultraviolet radiation and UV-like factors (Skin Cancer Foundation, 2015). This paper focuses on a specific type of skin cancer called Melanoma.

Melanoma is a malignant tumor that arises from pigment-producing skin cells termed melanocytes. When the cell division of these melanocytes becomes unregulated, they begin to divide and multiply too rapidly. This results in a cancerous overgrowth of these pigmented cells. Melanomas most frequently begin as a benign mole or freckle, which subsequently grow and transform into cancerous lesions. The most lethal type of skin cancer, melanoma is often a direct result of exposure to ultraviolet radiation from the sun (Ignatavicius, 2016).

Background Melanoma is one of the most serious types of cancer. “Melanoma begins in the melanocytes” (What Is Melanoma Skin Cancer?, 2017). Hippocrates, in the 5th century BC, was the first to record the founding of melanoma (Smith, 2015). It is caused by being in the sun too much without proper cover. “In 1956, Henry Lancaster made the initial connection between ultraviolet radiations from exposure to sunlight to increased incidence on melanoma (Smith, 2015).

Any type of change size, color, or shape of a mole is an important warning sign. For weeks or months, watch the changes that occur. The ABCDE rule is a helpful rule to estimate skin changes. A is asymmetry. If one half of a mole does not match the other have there is no symmetry. B is border irregularity. Jagged, uneven, or blurred edges of a mole should catch your attention. C is color. Changes in the mole color, particularly from the edge of the mole to the middle. D is for the diameter. If the mole is larger than 6mm the mole should be of concern. E is evolution. Changes in the surface size and shape, as well as itching or tenderness should be observed. Often time’s melanoma is developed in unmarked skin, but can also develop in existing moles or birthmarks (“Melanoma and Skin Cancer Symptoms”). Skin examinations should be an often routine provided by a doctor. Any notice of suspicious signs, see a health care provider as quick as possible. Examinations by a dermatologist are a potential way to see if you have developed skin cancer. If during the examination skin cancer is suspected a biopsy will probably be the next process (Knight).

Melanoma is a disease that develops in the cells of the skin (melanocytes). These are the cells that produce melanin, which is the pigment that gives skin its color. Melanoma can also be found in the eyes or internal organs such as the intestines. While melanoma is the most serious form of skin cancer, the source is idiopathic. Despite the cause being idiopathic, it is known that ultraviolet radiation from sources such as sunlight, and tanning beds increase the risk of melanoma development. Melanoma may be the most serious type of skin cancer, but it is still treatable if it is detected early.

Melanoma can spread quickly to other parts of the body and organs. In addition, it can begin wherever there is pigment, most appear spontaneously, and about one-third develop from preexisting moles. An estimated 9,940 people will die of melanoma in 2015 according to American Cancer Society (2015) (6). Although it accounts for less than two percent of skin cancer cases, melanoma composes the vast majority of skin cancer deaths. Indeed, certain populations are at a greater risk of getting skin

C. Melanoma Skin Cancer is the most dangerous form of skin cancer, it kills one person per hour, these cancerous growths are most often caused by ultraviolet radiation from sunshine or tanning beds. These tumors originate in the pigment-producing melanocytes in the basal layer of the epidermis. Melanoma is caused mainly by intense, occasional UV exposure (frequently leading to sunburn), especially in those who are genetically predisposed to the disease. Often the first sign of melanoma is a change in the size, shape, color or feel of a mole.