Megasterol acetate
1. Composition –
Megestrol acetate is a hormonal therapy drug most commonly used to treat breast cancer that has spread. It is also sometimes used to treat womb or prostate cancer.
Megestrol can also be used to improve symptoms such as hot flushes or loss of appetite.
2. Mode Of Action Megestrol is a drug that is similar to the female sex hormone progesterone. It may work by interfering with the hormone balance in the body, which may stop the cancer growing. It may also act directly on cancer cells so that they can’t grow.
3. Conditions used for –
This drug is used for the treatment of breast and endometrial cancers. supportive medication to treat severe loss of appetite (anorexia), muscle wasting and significant weight
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• Megasterol acetate passes through the breast milk hence should be avoided
• Drug is excreted through the kidney, hence patients with renal failure are at a higher risk
• Elderly patients have decreased renal functions , hence proper dose selection and calculation is necessary.
10. FAQs
a. Q: What should I discuss with my healthcare provider before taking Megasterol acetate drug?
Megsterol acetate is used for the treatment of cervical cancer, hence if you are planning to have a baby , consult your doctor as this drug interferes with the pregnancy cycle. In men the drug may interfere with the sperm production. In women menstrual bleeding may become irregular, dryness of vagina and itching are the side effects
b. Q: What should I do if I miss a dose?
Take the missed dose as soon as you remember. If it is near to the time for the next dose , skip the missed dose and resume your regular schedule. Do not double the next dose
c. Q: What happens if I overdose?
The drug will have severe side effects as mentioned above. Overdosing will lead to extreme health conditions and the cancer may develop resistance to the medicine.
d. Q: What should I know regarding storage of
In the role of a supplementary prescriber I could review him weekly and gradually increase his dose in line with the CMP dose schedule, his symptoms and tolerance. BNF (2014) additionally supports this by recommending the need for a re-assessment including physical health checks when a patient has reached a certain dose before titrating
Also, it comes in various flavors which will promote patient compliance and TA will enjoy using the product. According to the Handbook of Nonprescription Drugs and
It has broad variety of anti-tumor activity and forms the backbone of combination chemotherapy regimes presently
First, the medical assistant should convert the doctor’s prescription into layman’s terms for Doris. Medication A is two teaspoons by mouth every four hours. Medication B is 2.5 milliliters by mouth three times daily (Fulcher, Fulcher, & Soto, 2012, p. 1b). Doris should be cautious of confusing her medication dosages as that could lead to possible overdose. If Doris is afraid of mixing her medications, the medical assistant should convert to the unit that Doris is more comfortable with. For example, if Doris prefers milliliters, she should take around 9.8 milliliters of medication A. Alternatively, medication B could be taken at .5 teaspoons (Fulcher, Fulcher, & Soto, 2012, p. 131). Patients taking multiple medications should have a medication
6. The physician orders alendronate (Fosamax) 70mg/wk. what instructions should you give M.S. regarding alendronate?
• the dose to give and how often it may be repeated before referring to the resident’s doctor
Amantadine is symmetrel and it is an antiviral drug that has anti Parkinson benefits, its given early in the disease to reduce symptoms such as dyskinesia.
Earlier studies on mice have shown that the poison can specifically attack and destroy tumor cells.
Here are some of the benefits and effects associated with the medicine explaining why should one try the
that can worsen a person’s health. If the patient takes the prescribed drug correctly, than the drug
Clarify the order with the Physician involved. Refer to the drug guide or any reliable source if necessary.
Monastrol is a potent, reversible, and cell-permeant inhibitor of the motor protein Eg5 (kinesin family protein 11, Kif11), inducing the formation of monoastral spindles in cell-based assays with an IC50 value of 51.3 μM and blocking basal ATPase activity in vitro with an IC50 value of 6.1 µM. Monastrol arrested cells in mitosis without effects on other motor proteins and tubulin, therefore, it does not interfere with microtubule-dependent processes. Monastrol triggers the activation of the spindle assembly checkpoint, resulting in mitotic arrest which can lead to cell death in certain tumor cell lines. Eg5 is a member of the kinesin-5 family and responsible for the formation and maintenance of the bipolar spindle.
CathyAnn, great post. You have made a great point about renal impairment and being precautious when prescribing medication to elderly with CKD. Renal impairment can happen for numerous different reasons, a few of the reasons that renal impairment can happen are diabetic nephropathy, lupus, and aging (Burchum & Rosenthal, 2016 & Rull, 2016). With aging it is normal to have a decline in renal function. For this patient particularly, it would be important to make sure that if there is any medication that the nurse practitioner would be prescribing that would need to have renal dose adjustment it would be important to do testing to see what kind of adjustments needed to be made.
b.ii. The dosage will depend on the age, weight, and other health issues of the person.
According to the oral cancer foundation, “Chemotherapy is the use of chemicals to destroy cancer cells. Chemotherapy works by interfering with the cancer cell's ability to grow. It is one of the three main methods utilized to treat cancer.” With cancer being a potentially fatal disease it is important to diagnose it as soon as possible. the oncologist have to study the chemicals used so that they can determine what chemicals will treat the cancer or disease the best and what chemicals can be mixed together without any major side effects. The drugs can be divided into groups based on how they work, their chemical structure, and their relationship to other drugs.