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Medical Procedures And Treatment Of Patients

Decent Essays

Many standard procedures in surgeries nowadays that deal with biomaterial implants are loaded with antibiotics for local treatments and for the prevention of future implant infections. The goal of this approach is to rid the body of new infections or foreign bodies that may have entered during implantation of the biomaterial. The local release of antibiotics can be controlled and targeted based on the characteristics of the bacteria that are near the infection site. This route of treating infected tissues offers a never-before-seen possibility of an effective in situ treatment. Then again, some issues do raise concerning the effectiveness of this procedure with the fact that other experiments have been weakly proved to work.
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Although the antibiotic may cure or prevent some infections, bacteria can transform, causing a new line of bacteria to form which can become resistant to the current antibiotics. The authors also take into consideration the delivery system of the drug. They have their own input on how the delivery should be and what previous procedures are lacking.
The approach of the authors towards this topic is more of a theoretical approach rather than an experimental one. They emphasize that many of the controversies of using biomaterials loaded with antibiotics in surgeries will keep coming until some good randomized, double-blind clinical trials are properly and systematically conducted. They investigate each aspect of implanting a biomaterial in different ways and areas and then revolve around the possible outcomes, besides the desired ones, of the study. In one particular study, where they analyze the delivery systems of previous implants, they describe them to often fail to achieve ideal release kinetics. The authors propose that a desirable sustained release of drug should ensure that adequate tissue concentrations are maintained over a sufficient time to entirely cover the period after surgery where the wound is still prone to infection. They also propose four major components that must be taken

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