Role of serum magnesium in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Arunkumar Sreekumar1, Velayudhan K.K.1, R.N. Sharma1.
1. Department of General Medicine, Amrita Institute of Medical Sciences,
Amrita Vishwa Vidyapeetham.
Abstract
Background: Chronic Obstructive Pulmonary Disease (COPD) is defined as a chronic airflow obstruction that is progressive and only partially reversible. Today COPD is recognized as a major killer disease and the fourth most common cause of deaths in U.S.A. Available data suggest there are more than 12 million adults with COPD affection in India with estimated prevalence rates of 2.12% to 9.4% in north India and 1.4 % to 4.08% in Southern India1. Many studies have indicated that magnesium deficiency has contributed to exacerbation in COPD and that the treatment with intravenous magnesium in these patients helps in relieving bronchospasm by
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Materials and Methods:A prospective study was conducted at Amrita Institute of Medical Sciences, Kochi, Kerala. Our study made use of an observational model, the case control study, to possibly explore and confirm the association between serum magnesium levels and its influence over exacerbation of COPD as compared to those at stable COPD conditions. The study was done on 100 patients who were previously diagnosed with COPD.
Results: The mean magnesium values of stable COPD patients in our study averaged 2.08 and 2.06mg/dl for patients below and above 60 years of age respectively. Their corresponding mean scores during exacerbation were 1.58 and 1.6 mg/dl respectively, which is significant.
Conclusion: There exists a significant role of magnesium during COPD exacerbation, as compared to when they are stable.
Key words:
Exacerbation,COPD (Chronic Obstructive Pulmonary Disease), Serum Magnesium, Peak Expiratory Flow Rate, Stable COPD, Oxygen
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The purpose of this paper is to discuss an exacerbation of Chronic Obstructive Pulmonary Disease (COPD) and its effect on my patient, Mr. HS, a 78 year old male. In this paper we will look at the various facets in the disease process including its incidence, pathophysiology, presenting complaints, analysis of his clinical presentation, and discuss treatment. We will analyze the effect the disease process has on Mr. HS and will examine his clinical manifestations and laboratory work, as well as provide an outcome analysis. Understanding these various facets will enable one to understand
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Shortness of breath and wheezing are classical signs of COPD. The first part of the essay is discussed on pathophysiology of COPD. Another part is going to be informing on the pharmacology aspect of treating the disease. Nutrition also plays as a critical component of relieving the symptoms of the disease or aiding the work of medication. One of the signs that COPD can be established as a primary cause of illness is by receiving lab report on Arterial Blood Gases ABG.
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COPD is an important disease to be informed about because it affects millions of people. This paper discusses signs and symptoms, treatments, abnormalities you may find, as well as many of interesting things about COPD. Being informed about COPD can also possibly decrease your chances of developing the disease.
Chronic Obstructive Pulmonary Disease, also known as COPD, is the third leading cause of death in the United States. COPD includes extensive lungs diseases such as emphysema, non-reversible asthma, specific forms of bronchiectasis, and chronic bronchitis. This disease restricts the flow of air in and out of the lungs. Ways in which these limitations may occur include the loss of elasticity in the air sacs and throughout the airways, the destruction of the walls between air sacs, the inflammation or thickening of airway walls, or the overproduction of mucus in airways which can lead to blockage. Throughout this paper I am going to explain the main causes, symptoms, diagnosis, and ways to reduce COPD.
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