MDMA In Treating Schizophrenia

Schizophrenia is classified as a mental disorder that shows profound disruption of cognition and emotion which affects a person’s language, perception, thought and sense of self. The dopamine hypothesis states that schizophrenic’s neurones transmitting dopamine release the neurotransmitter too easily, leading to the characteristic symptoms of schizophrenia. This hypothesis claims that schizophrenics have abnormally high amounts of D2 receptors; receptors that receive dopamine, therefore resulting in a higher amount of D2 receptors binding to the receptors causing more impulses. Dopamine neurotransmitters play a

Psychological Transformation is a work that describes the effects of Methylenedioxymethamphetamine (MDMA) when used as a treatment for PTSD, depression and anxiety. Taken from the personal experiences of three individuals, the results are unparalleled in effectiveness. To describe the transition between pre-treatment and post-treatment, the piece is divided into three main sections: pre-MDMA (A, B, C and D), reaction and post-MDMA (A’, B’, C’ and D’).

Researchers believe that dopamine plays an important part in schizophrenia. The goal of conventional antipsychotic drug therapy is to reduce the amount of dopamine, or the amount of dopamine receptor sites. They are dopamine antagonists

Because of the prevalence of copious quantities of dopamine in people who have schizophrenia, most medications attempt to prevent the buildup of dopamine by blocking it in the striatum. Other methods in which drugs for this condition help to counteract the effects of dopamine, however, are more indirect. There are medications that are under development that "interfere with glutamate signals in the brain" (Nauert, 2010) that are targeted towards affecting glutamate, which in turn will then positively influence the levels of dopamine that the brain releases. In both ways then, (direct and indirect), dopamine is the primary focus of schizophrenia medication.

MDMA also known as molly may seem great at the moment, but taking molly is actually very dangerous. People should not use drugs if they do not really know about it. How would they know if it is legit or not. Drug use is not dying down, so if people want to use molly they should at least be safe about it. Molly is usually used to have great times at parties but most people do not even know the history of it, what it is, or what effects it has on the body.

Schizophrenic patients are thought to have higher dopamine levels in their brains (overactive dopamine system). Many antipsychotics are designed to block dopamine receptors, and bind them, helping patients to improve and experience less severe symptoms, further proving the dopamine hypothesis. It was also found that drugs that increase dopamine levels (amphetamines) have caused more psychotics symptoms. This could partially result in a few psychotic symptoms occurring in the illness (GROMISCH, 2013).

For the past fifty years treatment of schizophrenia has been marked by its basis on the dopamine hypothesis for schizophrenia. However, this model for the disease and its subsequent treatment have left many patients without relief or help in dealing with this disease which has lead to a search for a better model. The dopamine model lacks the recognition of a whole range of symptoms associated with the disease and therefore can not be an accurate basis for treatment. More recently, there has been a shift to the glutamate hypothesis which has been shown to more accurately characterize the wide range of symptoms experienced by patients living with this disorder as well as the possibility in improvements for drug treatments.

As we have seen, treatment of schizophrenia with antipsychotic drugs can have impressive results in terms of decreasing active symptoms, although it does nothing to alleviate negative symptoms or to improve cognitive functioning. Unfortunately, this kind of treatment has the drawback of extremely serious and even fatal side-effects. Newer generation atypical antipsychotics offer more hope, as they can treat both active and negative symptoms, and also improve cognitive functioning. Moreover, they have fewer side-effects. However, treatment is complicated by the fact that results are unpredictable; and in addition the side-effects that they do have can be very serious, such as diabetes, which in itself is life-threatening. However, as the potential side-effects are known, the physician has leeway to choose a drug which is a good match for the patient’s clinical profile. Then, once the patient’s symptoms have been much alleviated with an appropriate newer generation atypical antipsychotic, the patient should be able to also benefit from a range of psychotherapeutic interventions. It is argued that this is the best treatment regime to choose, as it is likely to result in the greatest improvement in quality of life, coupled with the lowest risk of potentially devastating side-effects, or of death. This is likely to be better than utilizing cognitive behavioral therapy, the results of which are not reliably known – although research has certainly shown that it is less efficacious

The Dopamine Hypothesis theorizes that the symptoms portrayed in Schizophrenia is can be explained by abnormal function of dopamine in the brain. There have been three versions of the Dopamine Hypothesis. The first version of the hypothesis focuses on the dopamine receptors. Antipsychotic drugs that impact the metabolization and reabsorption of dopamine where found to be effective in treating the symptoms. It was theorized that if the symptoms of a Schizophrenic episode can be treated by the use of dopamine

Over the years, experiments have produced evidence to suggest that dopamine plays a role in the development of Schizophrenia (Howes, McCutcheon, & Stone, 2015). Dopamine is a neurotransmitter that is produced in the substantia nigra and ventral tegmental regions of the brain. The belief that dopamine was involved in Schizophrenia arose after multiple studies performed with compounds produced an increase in extracellular concentrations of dopamine (Lieberman, Kane, & Alvir, 1987). The patients that were administered these compounds had similar symptoms to those observed from patients who were diagnosed with Schizophrenia (Lieberman et al., 1987).

release high levels of chemicals in the brain allow the emotional state of the individual be more

Worldwide about 1 percent of the population is diagnosed with schizophrenia, and approximately 1.2% of Americans (3.2 million) have the disorder. About 1.5 million people will be diagnosed with schizophrenia this year around the world. In the United States, this means about 100,000 people will be diagnosed, which translates to 7.2 people per 1,000 or about 21,000 people within a city of 3 million who are likely to be suffering from schizophrenia (Rashmi Nemade , Ph.D. & Mark Dombeck, Ph.D. Schizophrenia symptoms, patterns and statistics). Schizophrenia is a severe mental illness that affects the way a person thinks, acts and expresses emotions. People

Schizophrenia is a chronic brain disorder that affects more than one percent of the population. When schizophrenia is active, symptoms can include delusions, hallucinations, trouble with thinking and concentration, and lack of motivation. However, when these symptoms are treated properly, a large portion of those diagnosed will greatly improve over time.

Treatment of schizophrenia may vary according to what clinicians believe to be its causes. For example, some believe (and this is backed by evidence) that the condition is caused by over activity of the dopamine system, so that the person experiences too much stimulation. Dopamine is a neurotransmitter, so that in effect too much activity is occurring in the brain. Clinicians who believe this is the case are likely to use drug therapies to correct this over activity, and will use antipsychotic drugs.

The person I chose came from a famous novel and has schizophrenia. According to Mayo Clinic “Schizophrenia is a severe brain disorder in which people interpret reality abnormally. Schizophrenia may result in some combination of hallucinations, delusions, and extremely disordered thinking and behavior. Contrary to popular belief, schizophrenia is not a split personality or multiple personality. The word "schizophrenia" does mean "split mind," but it refers to a disruption of the usual balance of emotions and thinking. Schizophrenia is a chronic condition, requiring lifelong treatment.”(Schizophrenia, August 2014). The individual would start showing signs of reduced pleasure in life, difficulty participating in activities, barely speaking,