Lung Cancer : The Common Type Of Cancer

What are lung cancers? Lung cancers are the abnormal cells which grow in uncontrolled manner in one or both lungs. They do not function as normal lung cells and do not develop into healthy lung tissue. The abnormal cells can grow, form tumours and interfere with the normal functions of the lung (Lungcancer.org, 2015). Lung cancers can be divided into two major types, namely non-small cell lung cancers (NSCLC) and small cell lung cancers (SCLC). NSCLC can be further classified into three main subtypes, namely adenocarcinoma, squamous-cell carcinoma and large-cell carcinoma (Longo & Harrison, 2012). Lung cancers can be diagnosed by chest X-ray, computerised tomography (CT) scan, positron emission tomography-computerised tomography (PET-CT) scan, bronchoscopy and biopsy (Nhs.uk, 2015). Unfortunately, lung cancers are often diagnosed at the later stages. This is due to the unrecognisable symptoms and warning signs at the earlier stages. NSCLC are often diagnosed at stage IV which accounts for 30-40% of cases whereas 60% of SCLC is diagnosed at stage IV. Lung cancer usually originates from the cells lining the bronchi, bronchioles and alveoli. Carcinogens especially tobacco smoke will alter the gene expression of the normal human lung cells, resulting in cell mutation. The proto-oncogenes will be converted to mutated form, oncogenes. Mutation leads to the decreased expression of the tumour suppressor genes. This results in uncontrolled cell proliferation, cell

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Lung Cancer, like any other type of cancer, is the uncontrollable growth of cells in the lung tissue. The main causes that contribute to lung cancer include inhaling carcinogens (basically, smoking), exposure to ionizing radiation, viral infections and even air pollution. These factors basically damage the tissues lining the bronchi in the lung, leading the cancer to develop further (Vaporciyan & Nesbitt JC, 2000). Primary lung cancers that develop in the epithelial tissues of the lung are known as carcinomas and claim the top spot in terms of leading cancer-related death causes. As of 2004, lung cancer

Lung Cancer is a disease which consists of uncontrolled cell growth in lung tissues. Lung cancer consists of two types, Non-small cell lung cancer, and small cell lung cancer. (NSCLC) is the most common type of lung cancer. The bronchi are the large air tubes leading from the trachea to the lungs that convey air to and from the lungs, and where most lung cancers begin. The body normally maintains cell growth only

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It is wise, however, to have a doctor monitor the tumor over at least a two-years period in order to note any changes that might indicate the presence of cancer. Also, a biopsy or surgical removal of a tumor may be needed when the patient is a smoker, the patient has difficulty breathing, or other troubling symptoms, tests show that the cancer could be present, and the nodule continue to grow. The malignant lung cancer is divided into non- small cell lung cancer, small cell lung cancer, and lung carcinoid tumor. First, the non- small lung cancer is A group of lung cancers that are named for the kinds of cells found in the cancer and how the cells look under a microscope. The cancer cells of each type grow and spread in different ways. The three main types of non-small cell lung cancer are squamous cell carcinoma, large cell carcinoma, and adenocarcinoma. Non-small cell lung cancer is the most common kind of lung cancer. The first type of the non- small cell cancer is squamous cell carcinoma About 25% to 30% of all lung cancers are squamous cell carcinomas. These cancers start in early versions of squamous cells, which are flat cells that line the inside of the airways in the lungs. They are often linked to a history of smoking and tend to be found in the central part of the lungs, near a main airway (bronchus). The second type is larger cell carcinoma this type accounts for about 10% to 15% of lung cancers. It can appear in any part of the lung. It tends to grow and spread quickly, which can make it harder to treat. A subtype of large cell carcinoma, known as large cell, neuroendocrine carcinoma, is a fast-growing cancer that is very similar to small cell lung cancer. The third type of non- small cell lung cancer is adenocarcinoma about 40% of lung cancers are adenocarcinomas. that begins in the cells that line the alveoli and make substances such as

A common form of cancer that is very popular today is lung cancer. Lung cancer is a very dangerous form that can cause problems in simple body functions. These simple body functions are short breath and general fatigue. Lung cancer is commonly formed from smokers that has been exposed to that activity for numerous years. Lung cancer can also be spread by being exposed to asbestos or other pollutants. This form of cancer has many risk factors to it. These risk factors are high levels of air pollution, arsenic drinking water, and radon gas. Radon gas is a gas that is highly radioactive and is very sensitive to the body. Once radon is exposed to the body, it has a very high respiration rate which initially divide its radioactive cells- causing more significant damage to the body.

|Specific Purpose: |To inform readers on the causes, effects and treatments of lung cancer. |

Lung cancer is a genetic and acquired disease. Lung cancer is genetic because cancer in general is caused by changes to the genes that control the way our cells function, especially how they grow and divide. All of these changes include mutations in the DNA that makes up our genes. Genetic changes that increase cancer risk can be inherited from our parents, if the changes are presents in germ cells. Which are the reproductive cells of the body, those are the eggs and the sperm. Lung cancer is also acquired because as the result of errors that occur as cells divide a person’s lifetime or exposure to certain chemicals. Some examples of these chemicals are found in tobacco smoke, radiation, UV rays from the sun that damage DNA. “In general, cancer cells have more genetic changes than normal cells. But each person’s cancer has a unique combination of genetic alterations.” Some of these changes may be the result of cancer, rather than the cause. As the cancer continues to grow, additional changes will occur. Even within the same tumor, cancer cells may have different genetic changes.

Lung cancer can be caused by multiple factors and many factors can work together to cause someone to have lung cancer. Besides smoking, radon, secondhand smoke, the environment and someone’s occupation can all cause lung cancer. As we already know smoking is the number one cause of lung cancer cases worldwide and over forty-three million people just in the United States smoke cigarettes. There are more than fifty chemicals in tobacco smoke that are ingested each time someone smokes. Some of these chemicals include benzene (which can be found in pesticides and gasoline), Formaldehyde (which preserve dead bodies), pesticides (which are found on lawns and gardens) and Tobacco-specific N-nitrosamines (Martin, 2012). When a person inhales the chemicals in cigarettes, they inhale thousands of poisons, toxic metals, and

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Cellular / Molecular Basis: Lung cancer has two types; small cell and non small cell. The two types can be identified by their appearance when looked at with a microscope. It usually affects the cells that are lined along air passages in the lungs.

The most common cause of lung cancer is smoking cigarettes. 80% of people who have lung cancer got it from smoking. The longer you smoke cigarettes the better chance of getting lung cancer. Smoking at a young age increases the chance of getting lung cancer more then starting to smoke as an adult. The sooner you quit, the better your life will be. Passive smoking (secondhand smoking) can give you lung cancer if exposed for a long time to it.

It was one thought that lung cancer was strictly caused by lifestyle choices, but over the past years, it has been shown that lifestyle isn’t the thing that can potentially allow one to contract lung cancer. The environment along with tobacco use and genetics can also play a role in contracting lung cancer. In an industrial world, pollution has been a reoccurring problem. With emissions from vehicles and industrial power plants, air pollution and/or smog has been hovering over us. In places like China who are thriving in the industrial world, are being greatly affected by air pollution. According to Brody, “In Asia, lung cancer is alarmingly

Aside from the obvious cause of lung cancer, which is smoking, there are several others. However, almost all of these can be avoided. Preventable risk factors include smoking marijuana, inhaling certain chemicals like gasoline fuel or diesel exhaust, undergoing radiation therapy, and having a poor diet. But, the American Cancer Society affirms that about 87% of lung cancer cases are a result of smoking tobacco, and that some of the other 13% are caused by secondhand smoke (11). Out of all the risk factors for lung cancer, smoking has the biggest impact. This is also ironic, as smoking is the easiest factor to avoid. Theoretically this should be the least prominent factor, as it is a voluntary decision to start smoking and is easier to avoid than any of the other factors. Yet, about 47.1 million people in the United States smoke (American Heart Association), and willingly put themselves at risk for lung cancer. At the same time though, people do not start smoking just because they want to develop lung cancer later in life; there are numerous factors that play into their decision. For example, people are influenced to smoke for reasons such as peer pressure, a way to deal with stress, and people they look up to that smoke (Bonas). They think it will help them relieve stress, or fit in, and they do not think about the consequences that come with their newfound hobby. Eventually smokers find that they cannot quit, for both physical and psychological